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Neuroblastoma
Andrew T. Trout, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Neuroblastoma: Embryonic tumor derived from primitive neural crest cells along peripheral sympathetic chain

            IMAGING

            • General Features

              • Nuclear Medicine Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Pastor ER et al: Current management of neuroblastoma and future direction. Crit Rev Oncol Hematol. 138:38-43, 2019
                                        2. Agrawal A et al: MIBG (metaiodobenzylguanidine) theranostics in pediatric and adult malignancies. Br J Radiol. 91(1091):20180103, 2018
                                        3. Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-315, 2018
                                        4. Liu B et al: SPECT/CT MIBG Imaging Is Crucial in the Follow-up of the Patients With High-Risk Neuroblastoma. Clin Nucl Med. 43(4):232-238, 2018
                                        5. DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
                                        6. Xia J et al: Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 37(5):649-60, 2017
                                        7. Kiratli PÖ et al: Nuclear Medicine in Pediatric and Adolescent Tumors. Semin Nucl Med. 46(4):308-23, 2016
                                        8. Louis CU et al: Neuroblastoma: Molecular Pathogenesis and Therapy. Annu Rev Med. ePub, 2014
                                        9. Cohn SL et al: The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 27(2):289-97, 2009
                                        10. Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
                                        11. Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
                                        12. Leung A et al: Specificity of radioiodinated MIBG for neural crest tumors in childhood. J Nucl Med. 38(9):1352-7, 1997
                                        13. Shulkin BL et al: Iodine-131-metaiodobenzylguanidine and bone scintigraphy for the detection of neuroblastoma. J Nucl Med. 33(10):1735-40, 1992
                                        Related Anatomy
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Neuroblastoma: Embryonic tumor derived from primitive neural crest cells along peripheral sympathetic chain

                                                  IMAGING

                                                  • General Features

                                                    • Nuclear Medicine Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Pastor ER et al: Current management of neuroblastoma and future direction. Crit Rev Oncol Hematol. 138:38-43, 2019
                                                                              2. Agrawal A et al: MIBG (metaiodobenzylguanidine) theranostics in pediatric and adult malignancies. Br J Radiol. 91(1091):20180103, 2018
                                                                              3. Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-315, 2018
                                                                              4. Liu B et al: SPECT/CT MIBG Imaging Is Crucial in the Follow-up of the Patients With High-Risk Neuroblastoma. Clin Nucl Med. 43(4):232-238, 2018
                                                                              5. DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
                                                                              6. Xia J et al: Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 37(5):649-60, 2017
                                                                              7. Kiratli PÖ et al: Nuclear Medicine in Pediatric and Adolescent Tumors. Semin Nucl Med. 46(4):308-23, 2016
                                                                              8. Louis CU et al: Neuroblastoma: Molecular Pathogenesis and Therapy. Annu Rev Med. ePub, 2014
                                                                              9. Cohn SL et al: The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 27(2):289-97, 2009
                                                                              10. Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
                                                                              11. Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
                                                                              12. Leung A et al: Specificity of radioiodinated MIBG for neural crest tumors in childhood. J Nucl Med. 38(9):1352-7, 1997
                                                                              13. Shulkin BL et al: Iodine-131-metaiodobenzylguanidine and bone scintigraphy for the detection of neuroblastoma. J Nucl Med. 33(10):1735-40, 1992