Neuroblastoma: Embryonic tumor derived from primitive neural crest cells along peripheral sympathetic chain
IMAGING
General Features
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Pastor ER et al: Current management of neuroblastoma and future direction. Crit Rev Oncol Hematol. 138:38-43, 2019
Agrawal A et al: MIBG (metaiodobenzylguanidine) theranostics in pediatric and adult malignancies. Br J Radiol. 91(1091):20180103, 2018
Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-315, 2018
Liu B et al: SPECT/CT MIBG Imaging Is Crucial in the Follow-up of the Patients With High-Risk Neuroblastoma. Clin Nucl Med. 43(4):232-238, 2018
DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
Xia J et al: Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 37(5):649-60, 2017
Kiratli PÖ et al: Nuclear Medicine in Pediatric and Adolescent Tumors. Semin Nucl Med. 46(4):308-23, 2016
Louis CU et al: Neuroblastoma: Molecular Pathogenesis and Therapy. Annu Rev Med. ePub, 2014
Cohn SL et al: The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 27(2):289-97, 2009
Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
Leung A et al: Specificity of radioiodinated MIBG for neural crest tumors in childhood. J Nucl Med. 38(9):1352-7, 1997
Shulkin BL et al: Iodine-131-metaiodobenzylguanidine and bone scintigraphy for the detection of neuroblastoma. J Nucl Med. 33(10):1735-40, 1992
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
Neuroblastoma: Embryonic tumor derived from primitive neural crest cells along peripheral sympathetic chain
IMAGING
General Features
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Pastor ER et al: Current management of neuroblastoma and future direction. Crit Rev Oncol Hematol. 138:38-43, 2019
Agrawal A et al: MIBG (metaiodobenzylguanidine) theranostics in pediatric and adult malignancies. Br J Radiol. 91(1091):20180103, 2018
Li C et al: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F-FDG PET/CT in pediatric patients with neuroblastoma. Eur J Nucl Med Mol Imaging. 45(2):306-315, 2018
Liu B et al: SPECT/CT MIBG Imaging Is Crucial in the Follow-up of the Patients With High-Risk Neuroblastoma. Clin Nucl Med. 43(4):232-238, 2018
DuBois SG et al: MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 64(11), 2017
Xia J et al: Comparison of diagnosing and staging accuracy of PET (CT) and MIBG on patients with neuroblastoma: Systemic review and meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 37(5):649-60, 2017
Kiratli PÖ et al: Nuclear Medicine in Pediatric and Adolescent Tumors. Semin Nucl Med. 46(4):308-23, 2016
Louis CU et al: Neuroblastoma: Molecular Pathogenesis and Therapy. Annu Rev Med. ePub, 2014
Cohn SL et al: The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 27(2):289-97, 2009
Monclair T et al: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol. 27(2):298-303, 2009
Lonergan GJ et al: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 22(4):911-34, 2002
Leung A et al: Specificity of radioiodinated MIBG for neural crest tumors in childhood. J Nucl Med. 38(9):1352-7, 1997
Shulkin BL et al: Iodine-131-metaiodobenzylguanidine and bone scintigraphy for the detection of neuroblastoma. J Nucl Med. 33(10):1735-40, 1992
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