Catherine C. Roberts, MD; B.J. Manaster, MD, PhD, FACR
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9
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1
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Neurofibroma (NF)
Neurofibromatosis type 1 (NF1)
Definitions
Benign peripheral nerve sheath tumor with neoplastic tissue interspersed with normal nerve bundles
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Schaefer IM et al: Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse-type neurofibroma: clinicopathologic characterization in a series of 9 cases. Am J Surg Pathol. ePub, 2015
Ravi AK et al: Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum. Skeletal Radiol. 43(12):1773-8, 2014
Patel NB et al: Musculoskeletal manifestations of neurofibromatosis type 1. AJR Am J Roentgenol. 199(1):W99-106, 2012
Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74., 2010
Hassell DS et al: Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol. 190(3):582-8, 2008
Weiss SW et al: Benign tumors of peripheral nerves. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 835-53, 872-8, 888-92, 2008
Bredella MA et al: Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol. 189(4):928-35, 2007
Kransdorf MJ et al: Neurogenic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 335, 349-51, 2006
Cooper JA: Plexiform neurofibromatosis involving the colon. Radiographics. 25(2):454, 2005
Huang GS et al: On the AJR viewbox. Diffuse neurofibroma of the arm: MR characteristics. AJR Am J Roentgenol. 184(5):1711-2, 2005
Huang GS et al: Solitary intraosseous neurofibroma of the tibia. Skeletal Radiol. 34(5):303-6, 2005
Levy AD et al: From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation. Radiographics. 25(2):455-80, 2005
Lim R et al: Superficial neurofibroma: a lesion with unique MRI characteristics in patients with neurofibromatosis type 1. AJR Am J Roentgenol. 184(3):962-8, 2005
Jee WH et al: Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 183(3):629-33, 2004
Reynolds DL Jr et al: Sonographic characteristics of peripheral nerve sheath tumors. AJR Am J Roentgenol. 182(3):741-4, 2004
Wilkinson LM et al: Best cases from the AFIP: plexiform neurofibroma of the bladder. Radiographics. 24 Suppl 1:S237-42, 2004
Paksoy Y et al: Solitary juxtacortical neurofibroma of the humerus. Skeletal Radiol. 31(2):112-5, 2002
Fortman BJ et al: Neurofibromatosis type 1: a diagnostic mimicker at CT. Radiographics. 21(3):601-12, 2001
Lin J et al: Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol. 176(1):75-82, 2001
Murphey MD et al: From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 19(5):1253-80, 1999
Ogose A et al: Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol. 28(4):183-8, 1999
Sullivan TP et al: Case report 828: Plexiform neurofibroma of the tibial nerve invading the medial and lateral gastrocnemius muscles and plantaris muscle. Skeletal Radiol. 23(2):149-52, 1994
Stull MA et al: Magnetic resonance appearance of peripheral nerve sheath tumors. Skeletal Radiol. 20(1):9-14, 1991
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Neurofibroma (NF)
Neurofibromatosis type 1 (NF1)
Definitions
Benign peripheral nerve sheath tumor with neoplastic tissue interspersed with normal nerve bundles
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Schaefer IM et al: Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse-type neurofibroma: clinicopathologic characterization in a series of 9 cases. Am J Surg Pathol. ePub, 2015
Ravi AK et al: Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum. Skeletal Radiol. 43(12):1773-8, 2014
Patel NB et al: Musculoskeletal manifestations of neurofibromatosis type 1. AJR Am J Roentgenol. 199(1):W99-106, 2012
Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74., 2010
Hassell DS et al: Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol. 190(3):582-8, 2008
Weiss SW et al: Benign tumors of peripheral nerves. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 835-53, 872-8, 888-92, 2008
Bredella MA et al: Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol. 189(4):928-35, 2007
Kransdorf MJ et al: Neurogenic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 335, 349-51, 2006
Cooper JA: Plexiform neurofibromatosis involving the colon. Radiographics. 25(2):454, 2005
Huang GS et al: On the AJR viewbox. Diffuse neurofibroma of the arm: MR characteristics. AJR Am J Roentgenol. 184(5):1711-2, 2005
Huang GS et al: Solitary intraosseous neurofibroma of the tibia. Skeletal Radiol. 34(5):303-6, 2005
Levy AD et al: From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation. Radiographics. 25(2):455-80, 2005
Lim R et al: Superficial neurofibroma: a lesion with unique MRI characteristics in patients with neurofibromatosis type 1. AJR Am J Roentgenol. 184(3):962-8, 2005
Jee WH et al: Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 183(3):629-33, 2004
Reynolds DL Jr et al: Sonographic characteristics of peripheral nerve sheath tumors. AJR Am J Roentgenol. 182(3):741-4, 2004
Wilkinson LM et al: Best cases from the AFIP: plexiform neurofibroma of the bladder. Radiographics. 24 Suppl 1:S237-42, 2004
Paksoy Y et al: Solitary juxtacortical neurofibroma of the humerus. Skeletal Radiol. 31(2):112-5, 2002
Fortman BJ et al: Neurofibromatosis type 1: a diagnostic mimicker at CT. Radiographics. 21(3):601-12, 2001
Lin J et al: Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol. 176(1):75-82, 2001
Murphey MD et al: From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 19(5):1253-80, 1999
Ogose A et al: Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol. 28(4):183-8, 1999
Sullivan TP et al: Case report 828: Plexiform neurofibroma of the tibial nerve invading the medial and lateral gastrocnemius muscles and plantaris muscle. Skeletal Radiol. 23(2):149-52, 1994
Stull MA et al: Magnetic resonance appearance of peripheral nerve sheath tumors. Skeletal Radiol. 20(1):9-14, 1991
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