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KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Neurofibroma (NF)
- Neurofibromatosis type 1 (NF1)
Definitions
- Benign peripheral nerve sheath tumor with neoplastic tissue interspersed with normal nerve bundles
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Schaefer IM et al: Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse-type neurofibroma: clinicopathologic characterization in a series of 9 cases. Am J Surg Pathol. ePub, 2015
- Ravi AK et al: Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum. Skeletal Radiol. 43(12):1773-8, 2014
- Patel NB et al: Musculoskeletal manifestations of neurofibromatosis type 1. AJR Am J Roentgenol. 199(1):W99-106, 2012
- Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74., 2010
- Hassell DS et al: Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol. 190(3):582-8, 2008
- Weiss SW et al: Benign tumors of peripheral nerves. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 835-53, 872-8, 888-92, 2008
- Bredella MA et al: Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol. 189(4):928-35, 2007
- Kransdorf MJ et al: Neurogenic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 335, 349-51, 2006
- Cooper JA: Plexiform neurofibromatosis involving the colon. Radiographics. 25(2):454, 2005
- Huang GS et al: On the AJR viewbox. Diffuse neurofibroma of the arm: MR characteristics. AJR Am J Roentgenol. 184(5):1711-2, 2005
- Huang GS et al: Solitary intraosseous neurofibroma of the tibia. Skeletal Radiol. 34(5):303-6, 2005
- Levy AD et al: From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation. Radiographics. 25(2):455-80, 2005
- Lim R et al: Superficial neurofibroma: a lesion with unique MRI characteristics in patients with neurofibromatosis type 1. AJR Am J Roentgenol. 184(3):962-8, 2005
- Jee WH et al: Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 183(3):629-33, 2004
- Reynolds DL Jr et al: Sonographic characteristics of peripheral nerve sheath tumors. AJR Am J Roentgenol. 182(3):741-4, 2004
- Wilkinson LM et al: Best cases from the AFIP: plexiform neurofibroma of the bladder. Radiographics. 24 Suppl 1:S237-42, 2004
- Paksoy Y et al: Solitary juxtacortical neurofibroma of the humerus. Skeletal Radiol. 31(2):112-5, 2002
- Fortman BJ et al: Neurofibromatosis type 1: a diagnostic mimicker at CT. Radiographics. 21(3):601-12, 2001
- Lin J et al: Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol. 176(1):75-82, 2001
- Beggs I: Sonographic appearances of nerve tumors. J Clin Ultrasound. 27(7):363-8, 1999
- Murphey MD et al: From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 19(5):1253-80, 1999
- Ogose A et al: Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol. 28(4):183-8, 1999
- Sullivan TP et al: Case report 828: Plexiform neurofibroma of the tibial nerve invading the medial and lateral gastrocnemius muscles and plantaris muscle. Skeletal Radiol. 23(2):149-52, 1994
- Stull MA et al: Magnetic resonance appearance of peripheral nerve sheath tumors. Skeletal Radiol. 20(1):9-14, 1991
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References
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Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Neurofibroma (NF)
- Neurofibromatosis type 1 (NF1)
Definitions
- Benign peripheral nerve sheath tumor with neoplastic tissue interspersed with normal nerve bundles
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Schaefer IM et al: Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse-type neurofibroma: clinicopathologic characterization in a series of 9 cases. Am J Surg Pathol. ePub, 2015
- Ravi AK et al: Diffuse infiltrative neurofibroma: a clinical, radiological, and histological conundrum. Skeletal Radiol. 43(12):1773-8, 2014
- Patel NB et al: Musculoskeletal manifestations of neurofibromatosis type 1. AJR Am J Roentgenol. 199(1):W99-106, 2012
- Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74., 2010
- Hassell DS et al: Imaging appearance of diffuse neurofibroma. AJR Am J Roentgenol. 190(3):582-8, 2008
- Weiss SW et al: Benign tumors of peripheral nerves. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 835-53, 872-8, 888-92, 2008
- Bredella MA et al: Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol. 189(4):928-35, 2007
- Kransdorf MJ et al: Neurogenic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 335, 349-51, 2006
- Cooper JA: Plexiform neurofibromatosis involving the colon. Radiographics. 25(2):454, 2005
- Huang GS et al: On the AJR viewbox. Diffuse neurofibroma of the arm: MR characteristics. AJR Am J Roentgenol. 184(5):1711-2, 2005
- Huang GS et al: Solitary intraosseous neurofibroma of the tibia. Skeletal Radiol. 34(5):303-6, 2005
- Levy AD et al: From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation. Radiographics. 25(2):455-80, 2005
- Lim R et al: Superficial neurofibroma: a lesion with unique MRI characteristics in patients with neurofibromatosis type 1. AJR Am J Roentgenol. 184(3):962-8, 2005
- Jee WH et al: Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 183(3):629-33, 2004
- Reynolds DL Jr et al: Sonographic characteristics of peripheral nerve sheath tumors. AJR Am J Roentgenol. 182(3):741-4, 2004
- Wilkinson LM et al: Best cases from the AFIP: plexiform neurofibroma of the bladder. Radiographics. 24 Suppl 1:S237-42, 2004
- Paksoy Y et al: Solitary juxtacortical neurofibroma of the humerus. Skeletal Radiol. 31(2):112-5, 2002
- Fortman BJ et al: Neurofibromatosis type 1: a diagnostic mimicker at CT. Radiographics. 21(3):601-12, 2001
- Lin J et al: Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol. 176(1):75-82, 2001
- Beggs I: Sonographic appearances of nerve tumors. J Clin Ultrasound. 27(7):363-8, 1999
- Murphey MD et al: From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 19(5):1253-80, 1999
- Ogose A et al: Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol. 28(4):183-8, 1999
- Sullivan TP et al: Case report 828: Plexiform neurofibroma of the tibial nerve invading the medial and lateral gastrocnemius muscles and plantaris muscle. Skeletal Radiol. 23(2):149-52, 1994
- Stull MA et al: Magnetic resonance appearance of peripheral nerve sheath tumors. Skeletal Radiol. 20(1):9-14, 1991
