Autoimmune inflammatory disorder involving myelin of neurons of optic nerves and spinal cord with limited brain parenchymal involvement
IMAGING
General Features
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Baghbanian SM et al: A comparison of pediatric and adult neuromyelitis optica spectrum disorders: A review of clinical manifestation, diagnosis, and treatment. J Neurol Sci. 388:222-31, 2018
Baumann M et al: MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein. J Neurol. 265(4):845-55, 2018
Ikeda A et al: MRI findings in pediatric neuromyelitis optica spectrum disorder with MOG antibody: Four cases and review of the literature. Brain Dev. ePub, 2018
McGee JC et al: Neuromyelitis optica spectrum disorder in the very young: An in depth review of the present data. J Neurol Sci. 388:232, 2018
Akaishi T et al: Neuromyelitis optica spectrum disorders. Neuroimaging Clin N Am. 27(2):251-65, 2017
Patterson SL et al: Neuromyelitis Optica. Rheum Dis Clin North Am. 43(4):579-91, 2017
Chitnis T et al: Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology. 86(3):245-52, 2016
Tenembaum S et al: Neuromyelitis optica spectrum disorders in children and adolescents. Neurology. 87(9 Suppl 2):S59-66, 2016
Kitley J et al: Longitudinally extensive transverse myelitis with and without aquaporin 4 antibodies. JAMA Neurol. 70(11):1375-81, 2013
Mealy MA et al: Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions. Mult Scler Relat Disord. 28:64-68, 2018
Reindl M et al: Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol. ePub, 2018
Shahmohammadi S et al: Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review. Mult Scler Relat Disord. 27:350-363, 2018
Sato DK et al: Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders. Neurology. 80(24):2210-6, 2013
Morrow MJ et al: Neuromyelitis optica. J Neuroophthalmol. 32(2):154-66, 2012
Wynford-Thomas R et al: Neurological update: MOG antibody disease. J Neurol. ePub, 2018
Chan KH et al: Brain involvement in neuromyelitis optica spectrum disorders. Arch Neurol. 68(11):1432-9, 2011
de Seze J et al: Magnetic resonance spectroscopy evaluation in patients with neuromyelitis optica. J Neurol Neurosurg Psychiatry. 81(4):409-11, 2010
Lu Z et al: Characteristic linear lesions and longitudinally extensive spinal cord lesions in Chinese patients with neuromyelitis optica. J Neurol Sci. 293(1-2):92-6, 2010
Sellner J et al: The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes. J Autoimmun. 34(4):371-9, 2010
Bichuetti DB et al: Neuromyelitis optica in Brazil: a study on clinical and prognostic factors. Mult Scler. 15(5):613-9, 2009
Heerlein K et al: Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection. J Neurol Sci. 276(1-2):184-6, 2009
Jacob A: Neuromyelitis optica - an update: 2007-2009. Ann Indian Acad Neurol. 12(4):231-7, 2009
Zhang B et al: Correlation between serum thyroxine and complements in patients with multiple sclerosis and neuromyelitis optica. Neuro Endocrinol Lett. 29(2):256-60, 2008
Krupp LB et al: Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 68(16 Suppl 2):S7-12, 2007
Matiello M et al: Neuromyelitis optica. Curr Opin Neurol. 20(3):255-60, 2007
Pittock SJ et al: The pathology of MS: new insights and potential clinical applications. Neurologist. 13(2):45-56, 2007
Pohl D et al: Treatment of pediatric multiple sclerosis and variants. Neurology. 68(16 Suppl 2):S54-65, 2007
Takahashi T et al: Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain. 130(Pt 5):1235-43, 2007
Tanaka K et al: Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. Mult Scler. 2007
Wingerchuk DM et al: The spectrum of neuromyelitis optica. Lancet Neurol. 6(9):805-15, 2007
Wingerchuk DM et al: Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis. Curr Opin Neurol. 20(3):343-50, 2007
Wingerchuk DM: Neuromyelitis optica: new findings on pathogenesis. Int Rev Neurobiol. 79:665-88, 2007
Deshpande R et al: The natural history of multiple sclerosis. Adv Neurol. 98:1-15, 2006
Autoimmune inflammatory disorder involving myelin of neurons of optic nerves and spinal cord with limited brain parenchymal involvement
IMAGING
General Features
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Baghbanian SM et al: A comparison of pediatric and adult neuromyelitis optica spectrum disorders: A review of clinical manifestation, diagnosis, and treatment. J Neurol Sci. 388:222-31, 2018
Baumann M et al: MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein. J Neurol. 265(4):845-55, 2018
Ikeda A et al: MRI findings in pediatric neuromyelitis optica spectrum disorder with MOG antibody: Four cases and review of the literature. Brain Dev. ePub, 2018
McGee JC et al: Neuromyelitis optica spectrum disorder in the very young: An in depth review of the present data. J Neurol Sci. 388:232, 2018
Akaishi T et al: Neuromyelitis optica spectrum disorders. Neuroimaging Clin N Am. 27(2):251-65, 2017
Patterson SL et al: Neuromyelitis Optica. Rheum Dis Clin North Am. 43(4):579-91, 2017
Chitnis T et al: Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology. 86(3):245-52, 2016
Tenembaum S et al: Neuromyelitis optica spectrum disorders in children and adolescents. Neurology. 87(9 Suppl 2):S59-66, 2016
Kitley J et al: Longitudinally extensive transverse myelitis with and without aquaporin 4 antibodies. JAMA Neurol. 70(11):1375-81, 2013
Mealy MA et al: Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions. Mult Scler Relat Disord. 28:64-68, 2018
Reindl M et al: Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol. ePub, 2018
Shahmohammadi S et al: Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review. Mult Scler Relat Disord. 27:350-363, 2018
Sato DK et al: Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders. Neurology. 80(24):2210-6, 2013
Morrow MJ et al: Neuromyelitis optica. J Neuroophthalmol. 32(2):154-66, 2012
Wynford-Thomas R et al: Neurological update: MOG antibody disease. J Neurol. ePub, 2018
Chan KH et al: Brain involvement in neuromyelitis optica spectrum disorders. Arch Neurol. 68(11):1432-9, 2011
de Seze J et al: Magnetic resonance spectroscopy evaluation in patients with neuromyelitis optica. J Neurol Neurosurg Psychiatry. 81(4):409-11, 2010
Lu Z et al: Characteristic linear lesions and longitudinally extensive spinal cord lesions in Chinese patients with neuromyelitis optica. J Neurol Sci. 293(1-2):92-6, 2010
Sellner J et al: The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes. J Autoimmun. 34(4):371-9, 2010
Bichuetti DB et al: Neuromyelitis optica in Brazil: a study on clinical and prognostic factors. Mult Scler. 15(5):613-9, 2009
Heerlein K et al: Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection. J Neurol Sci. 276(1-2):184-6, 2009
Jacob A: Neuromyelitis optica - an update: 2007-2009. Ann Indian Acad Neurol. 12(4):231-7, 2009
Zhang B et al: Correlation between serum thyroxine and complements in patients with multiple sclerosis and neuromyelitis optica. Neuro Endocrinol Lett. 29(2):256-60, 2008
Krupp LB et al: Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 68(16 Suppl 2):S7-12, 2007
Matiello M et al: Neuromyelitis optica. Curr Opin Neurol. 20(3):255-60, 2007
Pittock SJ et al: The pathology of MS: new insights and potential clinical applications. Neurologist. 13(2):45-56, 2007
Pohl D et al: Treatment of pediatric multiple sclerosis and variants. Neurology. 68(16 Suppl 2):S54-65, 2007
Takahashi T et al: Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain. 130(Pt 5):1235-43, 2007
Tanaka K et al: Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. Mult Scler. 2007
Wingerchuk DM et al: The spectrum of neuromyelitis optica. Lancet Neurol. 6(9):805-15, 2007
Wingerchuk DM et al: Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis. Curr Opin Neurol. 20(3):343-50, 2007
Wingerchuk DM: Neuromyelitis optica: new findings on pathogenesis. Int Rev Neurobiol. 79:665-88, 2007
Deshpande R et al: The natural history of multiple sclerosis. Adv Neurol. 98:1-15, 2006