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Neuropathic (Charcot) Arthropathy
Derik L. Davis, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Charcot joint
            • Neuropathic osteoarthropathy; neuropathic joint disease
          • Definitions

            • Progressive joint destruction secondary to long-term polyneuropathy

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Rosskopf AB et al: The Charcot foot: a pictorial review. Insights Imaging. 10(1):77, 2019
                                      2. Ledbetter LN et al: Spinal neuroarthropathy: pathophysiology, clinical and imaging features, and differential diagnosis. Radiographics. 36(3):783-99, 2016
                                      3. Trieb K: The Charcot foot: pathophysiology, diagnosis and classification. Bone Joint J. 98-B(9):1155-9, 2016
                                      4. Peters EJ et al: Diagnosis and management of infection in the diabetic foot. Med Clin North Am. 97(5):911-46, 2013
                                      5. Zampa V et al: Role of dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus. Skeletal Radiol. 40(8):991-9, 2011
                                      6. Johnson PW et al: Diagnostic utility of T1-weighted MRI characteristics in evaluation of osteomyelitis of the foot. AJR Am J Roentgenol. 192(1):96-100, 2009
                                      7. Donovan A et al: Current concepts in imaging diabetic pedal osteomyelitis. Radiol Clin North Am. 46(6):1105-24, vii, 2008
                                      8. Ahmadi ME et al: Neuropathic arthropathy of the foot with and without superimposed osteomyelitis: MR imaging characteristics. Radiology. 238(2):622-31, 2006
                                      9. Rose DM et al: Charcot spinal arthropathy in a paraplegic weight lifter: case report. Spine. 31(11):E339-41, 2006
                                      10. Schwarz RJ et al: Results of arthrodesis in neuropathic feet. J Bone Joint Surg Br. 88(6):747-50, 2006
                                      11. Ledermann HP et al: Differential diagnosis of pedal osteomyelitis and diabetic neuroarthropathy: MR Imaging. Semin Musculoskelet Radiol. 9(3):272-83, 2005
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Charcot joint
                                                • Neuropathic osteoarthropathy; neuropathic joint disease
                                              • Definitions

                                                • Progressive joint destruction secondary to long-term polyneuropathy

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Staging, Grading, & Classification

                                                              • Gross Pathologic & Surgical Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Rosskopf AB et al: The Charcot foot: a pictorial review. Insights Imaging. 10(1):77, 2019
                                                                          2. Ledbetter LN et al: Spinal neuroarthropathy: pathophysiology, clinical and imaging features, and differential diagnosis. Radiographics. 36(3):783-99, 2016
                                                                          3. Trieb K: The Charcot foot: pathophysiology, diagnosis and classification. Bone Joint J. 98-B(9):1155-9, 2016
                                                                          4. Peters EJ et al: Diagnosis and management of infection in the diabetic foot. Med Clin North Am. 97(5):911-46, 2013
                                                                          5. Zampa V et al: Role of dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus. Skeletal Radiol. 40(8):991-9, 2011
                                                                          6. Johnson PW et al: Diagnostic utility of T1-weighted MRI characteristics in evaluation of osteomyelitis of the foot. AJR Am J Roentgenol. 192(1):96-100, 2009
                                                                          7. Donovan A et al: Current concepts in imaging diabetic pedal osteomyelitis. Radiol Clin North Am. 46(6):1105-24, vii, 2008
                                                                          8. Ahmadi ME et al: Neuropathic arthropathy of the foot with and without superimposed osteomyelitis: MR imaging characteristics. Radiology. 238(2):622-31, 2006
                                                                          9. Rose DM et al: Charcot spinal arthropathy in a paraplegic weight lifter: case report. Spine. 31(11):E339-41, 2006
                                                                          10. Schwarz RJ et al: Results of arthrodesis in neuropathic feet. J Bone Joint Surg Br. 88(6):747-50, 2006
                                                                          11. Ledermann HP et al: Differential diagnosis of pedal osteomyelitis and diabetic neuroarthropathy: MR Imaging. Semin Musculoskelet Radiol. 9(3):272-83, 2005