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Neutropenia
Sonia L. Betancourt-Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Granulocytopenia
            • Definitions

              • Neutropenia
                • Neutropenia: Abnormally low level of neutrophils in blood
                • Neutrophils defend body against bacterial and fungal infection
                • Can be hereditary or acquired
                • Absolute neutrophil count (ANC) of < 1,500/μL of blood
                  • Severe neutropenia < 500/μL
                  • Profound: < 100/μL
                • Neutropenic fever (temperature > 38°C): Common complication in cancer patients receiving chemotherapy
                • Neutropenia
                  • After chemotherapy in solid organ cancer usually lasts < 5 days
                  • After chemotherapy in hematologic malignancies usually lasts > 14 days
                  • After high-dose chemotherapy and radiation prehematopoietic stem cell transplantation: 0-100 days after transplantation

            IMAGING

            • General Concepts

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      • Image-Guided Biopsy

                        PATHOLOGY

                        • General Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Fan K et al: Imaging Evolution of an invasive fungal infection in a neutropenic patient. Ann Am Thorac Soc. 16(2):271-4, 2019
                                    2. Kunihiro Y et al: Differential diagnosis of pulmonary infections in immunocompromised patients using high-resolution computed tomography. Eur Radiol. 29(11):6089-99, 2019
                                    3. Long B et al: Oncologic emergencies: the fever with too few neutrophils. J Emerg Med. 57(5):689-700, 2019
                                    4. Wang J et al: Clinical diagnostic value of spiral CT in invasive pulmonary fungal infection. Exp Ther Med. 17(5):4149-53, 2019
                                    5. Caillot D et al: [Retrospective study of 25 cases of pulmonary mucormycosis in acute leukaemia.] Rev Mal Respir. 35(4):452-64, 2018
                                    6. Gerritsen MG et al: Improving early diagnosis of pulmonary infections in patients with febrile neutropenia using low-dose chest computed tomography. PLoS One. 12(2):e0172256, 2017
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Pathology

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Granulocytopenia
                                              • Definitions

                                                • Neutropenia
                                                  • Neutropenia: Abnormally low level of neutrophils in blood
                                                  • Neutrophils defend body against bacterial and fungal infection
                                                  • Can be hereditary or acquired
                                                  • Absolute neutrophil count (ANC) of < 1,500/μL of blood
                                                    • Severe neutropenia < 500/μL
                                                    • Profound: < 100/μL
                                                  • Neutropenic fever (temperature > 38°C): Common complication in cancer patients receiving chemotherapy
                                                  • Neutropenia
                                                    • After chemotherapy in solid organ cancer usually lasts < 5 days
                                                    • After chemotherapy in hematologic malignancies usually lasts > 14 days
                                                    • After high-dose chemotherapy and radiation prehematopoietic stem cell transplantation: 0-100 days after transplantation

                                              IMAGING

                                              • General Concepts

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        • Image-Guided Biopsy

                                                          PATHOLOGY

                                                          • General Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Fan K et al: Imaging Evolution of an invasive fungal infection in a neutropenic patient. Ann Am Thorac Soc. 16(2):271-4, 2019
                                                                      2. Kunihiro Y et al: Differential diagnosis of pulmonary infections in immunocompromised patients using high-resolution computed tomography. Eur Radiol. 29(11):6089-99, 2019
                                                                      3. Long B et al: Oncologic emergencies: the fever with too few neutrophils. J Emerg Med. 57(5):689-700, 2019
                                                                      4. Wang J et al: Clinical diagnostic value of spiral CT in invasive pulmonary fungal infection. Exp Ther Med. 17(5):4149-53, 2019
                                                                      5. Caillot D et al: [Retrospective study of 25 cases of pulmonary mucormycosis in acute leukaemia.] Rev Mal Respir. 35(4):452-64, 2018
                                                                      6. Gerritsen MG et al: Improving early diagnosis of pulmonary infections in patients with febrile neutropenia using low-dose chest computed tomography. PLoS One. 12(2):e0172256, 2017