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Nodal Hodgkin Lymphoma in Neck
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Hodgkin lymphoma (HL)
                • Classic Hodgkin lymphoma (CHL)
                • Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
            • Synonyms

              • Hodgkin disease
            • Definitions

              • All lymphomas designated HL or non-Hodgkin (NHL)
              • HL: Classic or nodular lymphocyte-predominant
                • Characterized by presence of Reed-Sternberg (RS) cells
              • NHL: B-cell or T-cell and NK-cell lymphomas/leukemias
              • CHL: Most common type of HL
              • NLPHL: More indolent, tends to respond and relapse
                • Behaves and is treated like low-grade NHL

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Adams HJ et al: Prognostic value of interim FDG-PET in Hodgkin lymphoma: systematic review and meta-analysis. Br J Haematol. 170(3):356-66, 2015
                                              2. Skelton E et al: Image-guided core needle biopsy in the diagnosis of malignant lymphoma. Eur J Surg Oncol. 41(7):852-8, 2015
                                              3. Chiaravalloti A et al: Initial staging of Hodgkin's disease: role of contrast-enhanced 18F FDG PET/CT. Medicine (Baltimore). 93(8):e50, 2014
                                              4. Ha CS et al: ACR appropriateness criteria follow-up of Hodgkin lymphoma. J Am Coll Radiol. 11(11):1026-1033.e3, 2014
                                              5. De Bruin ML et al: Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 101(13):928-37, 2009
                                              6. Papadopouli E et al: Cervical lymphadenopathy in childhood epidemiology and management. Pediatr Hematol Oncol. 26(6):454-60, 2009
                                              7. Pfeiffer J et al: Sonography-assisted cutting needle biopsy in the head and neck for the diagnosis of lymphoma: can it replace lymph node extirpation? Laryngoscope. 119(4):689-95, 2009
                                              8. Sengupta S et al: Clinicopathological correlates of pediatric head and neck cancer. J Cancer Res Ther. 5(3):181-5, 2009
                                              9. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                              10. Allen-Auerbach M et al: The impact of fluorodeoxyglucose-positron emission tomography in primary staging and patient management in lymphoma patients. Radiol Clin North Am. 46(2):199-211, vii, 2008
                                              11. Matasar MJ et al: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46(2):175-98, vii, 2008
                                              12. Sachdeva MU et al: Cerebrospinal fluid infiltration in Hodgkin lymphoma: a case report. Acta Cytol. 52(5):623-6, 2008
                                              13. Friedberg JW et al: PET scans in the staging of lymphoma: current status. Oncologist. 8(5):438-47, 2003
                                              14. Kogel KE et al: Current therapies in Hodgkin's disease. Eur J Nucl Med Mol Imaging. 30 Suppl 1:S19-27, 2003
                                              15. Vinnicombe SJ et al: Computerised tomography in the staging of Hodgkin's disease and non-Hodgkin's lymphoma. Eur J Nucl Med Mol Imaging. 30 Suppl 1:S42-55, 2003
                                              16. Weber AL et al: Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 13(3):371-92, 2003
                                              17. Kostakoglu L et al: Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and Ga-67 scintigraphy in evaluation of lymphoma. Cancer. 94(4):879-88, 2002
                                              18. Wirth A et al: Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin's disease and non-Hodgkin's lymphoma. Am J Med. 112(4):262-8, 2002
                                              19. Guermazi A et al: Extranodal Hodgkin disease: spectrum of disease. Radiographics. 21(1):161-79, 2001
                                              20. Urquhart A et al: Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 111(9):1565-9, 2001
                                              21. Diehl V et al: Hodgkin's disease. Cancer J. 6 Suppl 2:S150-8, 2000
                                              22. Powles T et al: HIV-associated Hodgkin's disease. Int J STD AIDS. 11(8):492-4, 2000
                                              23. Ahuja A et al: The use of sonography in differentiating cervical lymphomatous lymph nodes from cervical metastatic lymph nodes. Clin Radiol. 51(3):186-90, 1996
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Hodgkin lymphoma (HL)
                                                            • Classic Hodgkin lymphoma (CHL)
                                                            • Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
                                                        • Synonyms

                                                          • Hodgkin disease
                                                        • Definitions

                                                          • All lymphomas designated HL or non-Hodgkin (NHL)
                                                          • HL: Classic or nodular lymphocyte-predominant
                                                            • Characterized by presence of Reed-Sternberg (RS) cells
                                                          • NHL: B-cell or T-cell and NK-cell lymphomas/leukemias
                                                          • CHL: Most common type of HL
                                                          • NLPHL: More indolent, tends to respond and relapse
                                                            • Behaves and is treated like low-grade NHL

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Adams HJ et al: Prognostic value of interim FDG-PET in Hodgkin lymphoma: systematic review and meta-analysis. Br J Haematol. 170(3):356-66, 2015
                                                                                          2. Skelton E et al: Image-guided core needle biopsy in the diagnosis of malignant lymphoma. Eur J Surg Oncol. 41(7):852-8, 2015
                                                                                          3. Chiaravalloti A et al: Initial staging of Hodgkin's disease: role of contrast-enhanced 18F FDG PET/CT. Medicine (Baltimore). 93(8):e50, 2014
                                                                                          4. Ha CS et al: ACR appropriateness criteria follow-up of Hodgkin lymphoma. J Am Coll Radiol. 11(11):1026-1033.e3, 2014
                                                                                          5. De Bruin ML et al: Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 101(13):928-37, 2009
                                                                                          6. Papadopouli E et al: Cervical lymphadenopathy in childhood epidemiology and management. Pediatr Hematol Oncol. 26(6):454-60, 2009
                                                                                          7. Pfeiffer J et al: Sonography-assisted cutting needle biopsy in the head and neck for the diagnosis of lymphoma: can it replace lymph node extirpation? Laryngoscope. 119(4):689-95, 2009
                                                                                          8. Sengupta S et al: Clinicopathological correlates of pediatric head and neck cancer. J Cancer Res Ther. 5(3):181-5, 2009
                                                                                          9. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                                                                          10. Allen-Auerbach M et al: The impact of fluorodeoxyglucose-positron emission tomography in primary staging and patient management in lymphoma patients. Radiol Clin North Am. 46(2):199-211, vii, 2008
                                                                                          11. Matasar MJ et al: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46(2):175-98, vii, 2008
                                                                                          12. Sachdeva MU et al: Cerebrospinal fluid infiltration in Hodgkin lymphoma: a case report. Acta Cytol. 52(5):623-6, 2008
                                                                                          13. Friedberg JW et al: PET scans in the staging of lymphoma: current status. Oncologist. 8(5):438-47, 2003
                                                                                          14. Kogel KE et al: Current therapies in Hodgkin's disease. Eur J Nucl Med Mol Imaging. 30 Suppl 1:S19-27, 2003
                                                                                          15. Vinnicombe SJ et al: Computerised tomography in the staging of Hodgkin's disease and non-Hodgkin's lymphoma. Eur J Nucl Med Mol Imaging. 30 Suppl 1:S42-55, 2003
                                                                                          16. Weber AL et al: Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 13(3):371-92, 2003
                                                                                          17. Kostakoglu L et al: Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and Ga-67 scintigraphy in evaluation of lymphoma. Cancer. 94(4):879-88, 2002
                                                                                          18. Wirth A et al: Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin's disease and non-Hodgkin's lymphoma. Am J Med. 112(4):262-8, 2002
                                                                                          19. Guermazi A et al: Extranodal Hodgkin disease: spectrum of disease. Radiographics. 21(1):161-79, 2001
                                                                                          20. Urquhart A et al: Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 111(9):1565-9, 2001
                                                                                          21. Diehl V et al: Hodgkin's disease. Cancer J. 6 Suppl 2:S150-8, 2000
                                                                                          22. Powles T et al: HIV-associated Hodgkin's disease. Int J STD AIDS. 11(8):492-4, 2000
                                                                                          23. Ahuja A et al: The use of sonography in differentiating cervical lymphomatous lymph nodes from cervical metastatic lymph nodes. Clin Radiol. 51(3):186-90, 1996