link
Bookmarks
Nodal Non-Hodgkin Lymphoma in Retropharyngeal Space
Bronwyn E. Hamilton, MD
To access 4,300 diagnoses written by the world's leading experts in radiology.Try it free - 15 days
0
9
3
1

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Non-Hodgkin lymphoma (NHL) in retropharyngeal space (RPS)
            • Definitions

              • NHL is lymphoreticular system malignancy
                • H&N NHL has multiple forms
                  • Nodal, nonnodal lymphatic (tonsils & adenoids), extralymphatic (e.g., thyroid, sinuses)
              • RPS skull base to hyoid contains lateral & medial nodes
                • Lateral group = nodes of Rouvière

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Aiken AH et al: Approach to masses in head and neck spaces. In: Diseases of the Brain, Head and Neck, Spine 2020–2023: Diagnostic Imaging. [Internet]. Hodler J et al, editors. Cham: Springer, 2020
                                      2. Becker J et al: FDG PET hybrid imaging. Recent Results Cancer Res. 216:625-67, 2020
                                      3. Payabvash S et al: Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis. Neuroradiology. 61(8):897-910, 2019
                                      4. Peacock JG et al: RESISTing the need to quantify: putting qualitative FDG-PET/CT tumor response assessment criteria into daily practice. AJNR Am J Neuroradiol. 40(12):1978-86, 2019
                                      5. Surov A et al: Apparent diffusion coefficient for distinguishing between malignant and benign lesions in the head and neck region: a systematic review and meta-analysis. Front Oncol. 9:1362, 2019
                                      6. Loke SC et al: Superior cervical ganglion mimicking retropharyngeal adenopathy in head and neck cancer patients: MRI features with anatomic, histologic, and surgical correlation. Neuroradiology. 58(1):45-50, 2016
                                      7. Swerdlow SH et al: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. 127(20):2375-90, 2016
                                      8. Lee N et al: Significance of incidental nasopharyngeal uptake on (18)F-FDG PET/CT: patterns of benign/physiologic uptake and differentiation from malignancy. Nucl Med Mol Imaging. 49(1):11-8, 2015
                                      9. Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
                                      10. Fornage BD et al: Use of transoral sonography with an endocavitary transducer in diagnosis, fine-needle aspiration biopsy, and intraoperative localization of retropharyngeal masses. AJR Am J Roentgenol. 202(5):W481-6, 2014
                                      11. Hagtvedt T et al: Enhancement characteristics of lymphomatous lymph nodes of the neck. Acta Radiol. 51(5):555-62, 2010
                                      12. Kwee TC et al: ADC measurements of lymph nodes: inter- and intra-observer reproducibility study and an overview of the literature. Eur J Radiol. 75(2):215-20, 2010
                                      13. Agarwal V et al: Indications for PET/CT in the head and neck. Otolaryngol Clin North Am. 41(1):23-49, v, 2008
                                      14. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                      15. Byun BH et al: Clinical significance of 18F-FDG uptake by primary sites in patients with diffuse large B cell lymphoma in the head and neck: a pilot study. Ann Nucl Med. 22(8):645-51, 2008
                                      16. Choi JW et al: Peripheral T-cell lymphoma in the neck: CT findings of lymph node involvement. AJNR Am J Neuroradiol. 27(5):1079-82, 2006
                                      17. King AD et al: MRI of neck nodes in non-Hodgkin's lymphoma of the head and neck. Br J Radiol. 77(914):111-5, 2004
                                      18. King AD et al: Non-Hodgkin's lymphoma of the nasopharynx: CT and MR imaging. Clin Radiol. 58(8):621-5, 2003
                                      19. Sumi M et al: Discrimination of metastatic cervical lymph nodes with diffusion-weighted MR imaging in patients with head and neck cancer. AJNR Am J Neuroradiol. 24(8):1627-34, 2003
                                      20. Weber AL et al: Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 13(3):371-92, 2003
                                      21. Sakai O et al: Lymph node pathology. Benign proliferative, lymphoma, and metastatic disease. Radiol Clin North Am. 38(5):979-98, x, 2000
                                      22. Harnsberger HR et al: Non-Hodgkin's lymphoma of the head and neck: CT evaluation of nodal and extranodal sites. AJR Am J Roentgenol. 149(4):785-91, 1987
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Non-Hodgkin lymphoma (NHL) in retropharyngeal space (RPS)
                                                • Definitions

                                                  • NHL is lymphoreticular system malignancy
                                                    • H&N NHL has multiple forms
                                                      • Nodal, nonnodal lymphatic (tonsils & adenoids), extralymphatic (e.g., thyroid, sinuses)
                                                  • RPS skull base to hyoid contains lateral & medial nodes
                                                    • Lateral group = nodes of Rouvière

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Aiken AH et al: Approach to masses in head and neck spaces. In: Diseases of the Brain, Head and Neck, Spine 2020–2023: Diagnostic Imaging. [Internet]. Hodler J et al, editors. Cham: Springer, 2020
                                                                          2. Becker J et al: FDG PET hybrid imaging. Recent Results Cancer Res. 216:625-67, 2020
                                                                          3. Payabvash S et al: Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis. Neuroradiology. 61(8):897-910, 2019
                                                                          4. Peacock JG et al: RESISTing the need to quantify: putting qualitative FDG-PET/CT tumor response assessment criteria into daily practice. AJNR Am J Neuroradiol. 40(12):1978-86, 2019
                                                                          5. Surov A et al: Apparent diffusion coefficient for distinguishing between malignant and benign lesions in the head and neck region: a systematic review and meta-analysis. Front Oncol. 9:1362, 2019
                                                                          6. Loke SC et al: Superior cervical ganglion mimicking retropharyngeal adenopathy in head and neck cancer patients: MRI features with anatomic, histologic, and surgical correlation. Neuroradiology. 58(1):45-50, 2016
                                                                          7. Swerdlow SH et al: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. 127(20):2375-90, 2016
                                                                          8. Lee N et al: Significance of incidental nasopharyngeal uptake on (18)F-FDG PET/CT: patterns of benign/physiologic uptake and differentiation from malignancy. Nucl Med Mol Imaging. 49(1):11-8, 2015
                                                                          9. Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
                                                                          10. Fornage BD et al: Use of transoral sonography with an endocavitary transducer in diagnosis, fine-needle aspiration biopsy, and intraoperative localization of retropharyngeal masses. AJR Am J Roentgenol. 202(5):W481-6, 2014
                                                                          11. Hagtvedt T et al: Enhancement characteristics of lymphomatous lymph nodes of the neck. Acta Radiol. 51(5):555-62, 2010
                                                                          12. Kwee TC et al: ADC measurements of lymph nodes: inter- and intra-observer reproducibility study and an overview of the literature. Eur J Radiol. 75(2):215-20, 2010
                                                                          13. Agarwal V et al: Indications for PET/CT in the head and neck. Otolaryngol Clin North Am. 41(1):23-49, v, 2008
                                                                          14. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                                                          15. Byun BH et al: Clinical significance of 18F-FDG uptake by primary sites in patients with diffuse large B cell lymphoma in the head and neck: a pilot study. Ann Nucl Med. 22(8):645-51, 2008
                                                                          16. Choi JW et al: Peripheral T-cell lymphoma in the neck: CT findings of lymph node involvement. AJNR Am J Neuroradiol. 27(5):1079-82, 2006
                                                                          17. King AD et al: MRI of neck nodes in non-Hodgkin's lymphoma of the head and neck. Br J Radiol. 77(914):111-5, 2004
                                                                          18. King AD et al: Non-Hodgkin's lymphoma of the nasopharynx: CT and MR imaging. Clin Radiol. 58(8):621-5, 2003
                                                                          19. Sumi M et al: Discrimination of metastatic cervical lymph nodes with diffusion-weighted MR imaging in patients with head and neck cancer. AJNR Am J Neuroradiol. 24(8):1627-34, 2003
                                                                          20. Weber AL et al: Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 13(3):371-92, 2003
                                                                          21. Sakai O et al: Lymph node pathology. Benign proliferative, lymphoma, and metastatic disease. Radiol Clin North Am. 38(5):979-98, x, 2000
                                                                          22. Harnsberger HR et al: Non-Hodgkin's lymphoma of the head and neck: CT evaluation of nodal and extranodal sites. AJR Am J Roentgenol. 149(4):785-91, 1987