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Nodular Lymphoid Hyperplasia
Santiago Martínez-Jiménez, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Nodular lymphoid hyperplasia (NLH)
            • Definitions

              • Reactive nodular lymphoid proliferation that manifests with pulmonary nodule(s)/mass(es)

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            • Immunohistochemical and Molecular Studies

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Fang L et al: Pulmonary nodular lymphoid hyperplasia: a rare benign disease with malignant mask. Ann Transl Med. 7(3):43, 2019
                                      2. Yell M et al: Pulmonary nodular lymphoid hyperplasia. Arch Pathol Lab Med. 143(9):1149-53, 2019
                                      3. Park JY et al: Pulmonary nodular lymphoid hyperplasia in a 33-year-old woman. Korean J Thorac Cardiovasc Surg. 51(2):133-7, 2018
                                      4. Sim J et al: Pulmonary nodular lymphoid hyperplasia with mass-formation: clinicopathologic characteristics of nine cases and review of the literature. J Pathol Transl Med. 52(4):211-8, 2018
                                      5. Carrillo J et al: Lymphoproliferative lung disorders: a radiologic-pathologic overview. Part I: reactive disorders. Semin Ultrasound CT MR. 34(6):525-34, 2013
                                      6. Guinee DG Jr: Update on nonneoplastic pulmonary lymphoproliferative disorders and related entities. Arch Pathol Lab Med. 134(5):691-701, 2010
                                      7. Miyoshi S et al: A case of pulmonary nodular lymphoid hyperplasia with a resected cavity, followed by spontaneous regression of the remaining lesions. Intern Med. 49(15):1617-21, 2010
                                      8. Karube Y et al: Nodular lymphoid hyperplasia: rare case of lymphoproliferative disease in the lung. Gen Thorac Cardiovasc Surg. 57(6):324-7, 2009
                                      9. Nakamura H et al: Multifocal nodular lymphoid hyperplasia of the lung differently identified by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Thorac Cardiovasc Surg. 57(7):439-40, 2009
                                      10. Yilmaz U et al: Nodular lymphoid hyperplasia of the lung: the role of positron emission tomography in diagnosis. Tuberk Toraks. 57(4):417-21, 2009
                                      11. Song MK et al: Pulmonary nodular lymphoid hyperplasia associated with Sjögren's syndrome. Korean J Intern Med. 22(3):192-6, 2007
                                      12. Do KH et al: Pulmonary parenchymal involvement of low-grade lymphoproliferative disorders. J Comput Assist Tomogr. 29(6):825-30, 2005
                                      13. Kajiwara S et al: Multifocal nodular lymphoid hyperplasia of the lung. J Thorac Imaging. 20(3):239-41, 2005
                                      14. Holland EA et al: Evolution of pulmonary pseudolymphomas: clinical and radiologic manifestations. J Thorac Imaging. 6(4):74-80, 1991
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Nodular lymphoid hyperplasia (NLH)
                                                • Definitions

                                                  • Reactive nodular lymphoid proliferation that manifests with pulmonary nodule(s)/mass(es)

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • Nuclear Medicine Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                • Immunohistochemical and Molecular Studies

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Fang L et al: Pulmonary nodular lymphoid hyperplasia: a rare benign disease with malignant mask. Ann Transl Med. 7(3):43, 2019
                                                                          2. Yell M et al: Pulmonary nodular lymphoid hyperplasia. Arch Pathol Lab Med. 143(9):1149-53, 2019
                                                                          3. Park JY et al: Pulmonary nodular lymphoid hyperplasia in a 33-year-old woman. Korean J Thorac Cardiovasc Surg. 51(2):133-7, 2018
                                                                          4. Sim J et al: Pulmonary nodular lymphoid hyperplasia with mass-formation: clinicopathologic characteristics of nine cases and review of the literature. J Pathol Transl Med. 52(4):211-8, 2018
                                                                          5. Carrillo J et al: Lymphoproliferative lung disorders: a radiologic-pathologic overview. Part I: reactive disorders. Semin Ultrasound CT MR. 34(6):525-34, 2013
                                                                          6. Guinee DG Jr: Update on nonneoplastic pulmonary lymphoproliferative disorders and related entities. Arch Pathol Lab Med. 134(5):691-701, 2010
                                                                          7. Miyoshi S et al: A case of pulmonary nodular lymphoid hyperplasia with a resected cavity, followed by spontaneous regression of the remaining lesions. Intern Med. 49(15):1617-21, 2010
                                                                          8. Karube Y et al: Nodular lymphoid hyperplasia: rare case of lymphoproliferative disease in the lung. Gen Thorac Cardiovasc Surg. 57(6):324-7, 2009
                                                                          9. Nakamura H et al: Multifocal nodular lymphoid hyperplasia of the lung differently identified by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Thorac Cardiovasc Surg. 57(7):439-40, 2009
                                                                          10. Yilmaz U et al: Nodular lymphoid hyperplasia of the lung: the role of positron emission tomography in diagnosis. Tuberk Toraks. 57(4):417-21, 2009
                                                                          11. Song MK et al: Pulmonary nodular lymphoid hyperplasia associated with Sjögren's syndrome. Korean J Intern Med. 22(3):192-6, 2007
                                                                          12. Do KH et al: Pulmonary parenchymal involvement of low-grade lymphoproliferative disorders. J Comput Assist Tomogr. 29(6):825-30, 2005
                                                                          13. Kajiwara S et al: Multifocal nodular lymphoid hyperplasia of the lung. J Thorac Imaging. 20(3):239-41, 2005
                                                                          14. Holland EA et al: Evolution of pulmonary pseudolymphomas: clinical and radiologic manifestations. J Thorac Imaging. 6(4):74-80, 1991