link
Bookmarks
Non-Hodgkin Lymphoma of Pharyngeal Mucosal Space
Patricia A. Hudgins, MD, FACR
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
11
3
3

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Non-Hodgkin lymphoma (NHL) of pharyngeal mucosal space (PMS)
              • Synonyms

                • Multiple subtypes, usually B- or T-cell categories
                  • B-cell types: Burkitt, diffuse large, follicular, immunoblastic large cell, mantle cell, chronic lymphocytic lymphoma (CLL), mucosa-associated lymphoid tissue (MALT)
                  • T-cell types: Anaplastic large cell, precursor T-lymphoblastic, mycosis fungoides
              • Definitions

                • PMS contains Waldeyer lymphatic ring where extranodal, lymphatic NHL arises
                • 3 subsites of Waldeyer lymphatic ring: Adenoids, palatine tonsils, lingual tonsil
                  • Adenoids located in nasopharyngeal portion of PMS
                  • Palatine tonsils located in oropharyngeal portion of PMS
                  • Lingual tonsil located in oropharyngeal portion of PMS

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Heacock L et al: PET/MRI for the evaluation of patients with lymphoma: initial observations. AJR Am J Roentgenol. 204(4):842-8, 2015
                                                  2. Mosavi F et al: Whole-body diffusion-weighted MRI and 18F-FDG PET/CT can discriminate between different lymphoma subtypes. Clin Radiol. ePub, 2015
                                                  3. Takano S et al: Site-specific analysis of B-cell non-Hodgkin's lymphomas of the head and neck: A retrospective 10-year observation. Acta Otolaryngol. 1-4, 2015
                                                  4. Mayerhoefer ME et al: Evaluation of diffusion-weighted MRI for pretherapeutic assessment and staging of lymphoma: results of a prospective study in 140 patients. Clin Cancer Res. 20(11):2984-93, 2014
                                                  5. Punwani S et al: Diffusion-weighted MRI of lymphoma: prognostic utility and implications for PET/MRI? Eur J Nucl Med Mol Imaging. 40(3):373-85, 2013
                                                  6. Gu J et al: Whole-body diffusion-weighted imaging: the added value to whole-body MRI at initial diagnosis of lymphoma. AJR Am J Roentgenol. 197(3):W384-91, 2011
                                                  7. Chang DT et al: Long-term outcomes for stage I-II aggressive non-Hodgkin lymphoma of Waldeyer's ring. Am J Clin Oncol. 32(3):233-7, 2009
                                                  8. Mawardi H et al: Medical management update: Non-Hodgkin lymphoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 107(1):e19-33, 2009
                                                  9. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                                  10. Laskar S et al: Non-Hodgkin lymphoma of the Waldeyer's ring: clinicopathologic and therapeutic issues. Leuk Lymphoma. 49(12):2263-71, 2008
                                                  11. Roh JL et al: Lymphomas of the head and neck in the pediatric population. Int J Pediatr Otorhinolaryngol. 71(9):1471-7, 2007
                                                  12. Arias-Mendoza F et al: In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. NMR Biomed. 19(4):504-12, 2006
                                                  13. Mendenhall WM et al: Lethal midline granuloma-nasal natural killer/T-cell lymphoma. Am J Clin Oncol. 29(2):202-6, 2006
                                                  14. Shine NP et al: Extranodal lymphoma: clinical presentation and diagnostic pitfalls. Hosp Med. 66(6):341-5, 2005
                                                  15. King AD et al: Non-Hodgkin lymphoma of the larynx: CT and MR imaging findings. AJNR Am J Neuroradiol. 25(1):12-5, 2004
                                                  16. Banthia V et al: Sporadic Burkitt's lymphoma of the head and neck in the pediatric population. Int J Pediatr Otorhinolaryngol. 67(1):59-65, 2003
                                                  17. Gordin A et al: Extension of nasopharyngeal lymphoma to the middle and external ear. Ann Otol Rhinol Laryngol. 112(7):644-6, 2003
                                                  18. Gurkaynak M et al: Waldeyer's ring lymphomas: treatment results and prognostic factors. Am J Clin Oncol. 26(5):437-40, 2003
                                                  19. Gustavsson A et al: A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma. Acta Oncol. 42(5-6):605-19, 2003
                                                  20. King AD et al: Non-Hodgkin's lymphoma of the nasopharynx: CT and MR imaging. Clin Radiol. 58(8):621-5, 2003
                                                  21. Prades E et al: Extranodal lymphoma originating from mucosa-associated lymphoid tissue of the nasopharynx. Acta Otolaryngol. 123(9):1098-101, 2003
                                                  22. Suefuji H et al: HTLV-1 carriers with B-cell lymphoma of localized stage head and neck: prognosis, clinical and immunopathological features. Br J Haematol. 123(4):606-12, 2003
                                                  23. Weber AL et al: Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 13(3):371-92, 2003
                                                  24. Urquhart AC et al: Distinguishing non-Hodgkin lymphoma from squamous cell carcinoma tumors of the head and neck by computed tomography parameters. Laryngoscope. 112(6):1079-83, 2002
                                                  25. Vargas H et al: Posttransplant lymphoproliferative disorder of the nasopharynx. Am J Rhinol. 16(1):37-42, 2002
                                                  26. Vicente-Barrero M et al: Non-Hodgkin lymphomas of oral cavity. Vojnosanit Pregl. 59(6):669-73, 2002
                                                  27. Urquhart A et al: Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 111(9):1565-9, 2001
                                                  28. King AD et al: MR imaging of nasal T-cell/natural killer cell lymphoma. AJR Am J Roentgenol. 174(1):209-11, 2000
                                                  29. Liang R: Diagnosis and management of primary nasal lymphoma of T-cell or NK-cell origin. Clin Lymphoma. 1(1):33-7; discussion 38, 2000
                                                  30. Ooi GC et al: Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol. 174(4):1141-5, 2000
                                                  31. Yaris N et al: Nasal-paranasal-oronasopharyngeal lymphomas in childhood: the role of staging system on prognosis. Pediatr Hematol Oncol. 17(5):345-53, 2000
                                                  32. Ascoli V et al: Extranodal lymphomas associated with hepatitis C virus infection. Am J Clin Pathol. 109(5):600-9, 1998
                                                  33. Cheung MM et al: Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients. J Clin Oncol. 16(1):70-7, 1998
                                                  34. Hanna E et al: Extranodal lymphomas of the head and neck. A 20-year experience. Arch Otolaryngol Head Neck Surg. 123(12):1318-23, 1997
                                                  Related Anatomy
                                                  Loading...
                                                  Related Differential Diagnoses
                                                  Loading...
                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Non-Hodgkin lymphoma (NHL) of pharyngeal mucosal space (PMS)
                                                              • Synonyms

                                                                • Multiple subtypes, usually B- or T-cell categories
                                                                  • B-cell types: Burkitt, diffuse large, follicular, immunoblastic large cell, mantle cell, chronic lymphocytic lymphoma (CLL), mucosa-associated lymphoid tissue (MALT)
                                                                  • T-cell types: Anaplastic large cell, precursor T-lymphoblastic, mycosis fungoides
                                                              • Definitions

                                                                • PMS contains Waldeyer lymphatic ring where extranodal, lymphatic NHL arises
                                                                • 3 subsites of Waldeyer lymphatic ring: Adenoids, palatine tonsils, lingual tonsil
                                                                  • Adenoids located in nasopharyngeal portion of PMS
                                                                  • Palatine tonsils located in oropharyngeal portion of PMS
                                                                  • Lingual tonsil located in oropharyngeal portion of PMS

                                                              IMAGING

                                                              • General Features

                                                                • Radiographic Findings

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Nuclear Medicine Findings

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Heacock L et al: PET/MRI for the evaluation of patients with lymphoma: initial observations. AJR Am J Roentgenol. 204(4):842-8, 2015
                                                                                                  2. Mosavi F et al: Whole-body diffusion-weighted MRI and 18F-FDG PET/CT can discriminate between different lymphoma subtypes. Clin Radiol. ePub, 2015
                                                                                                  3. Takano S et al: Site-specific analysis of B-cell non-Hodgkin's lymphomas of the head and neck: A retrospective 10-year observation. Acta Otolaryngol. 1-4, 2015
                                                                                                  4. Mayerhoefer ME et al: Evaluation of diffusion-weighted MRI for pretherapeutic assessment and staging of lymphoma: results of a prospective study in 140 patients. Clin Cancer Res. 20(11):2984-93, 2014
                                                                                                  5. Punwani S et al: Diffusion-weighted MRI of lymphoma: prognostic utility and implications for PET/MRI? Eur J Nucl Med Mol Imaging. 40(3):373-85, 2013
                                                                                                  6. Gu J et al: Whole-body diffusion-weighted imaging: the added value to whole-body MRI at initial diagnosis of lymphoma. AJR Am J Roentgenol. 197(3):W384-91, 2011
                                                                                                  7. Chang DT et al: Long-term outcomes for stage I-II aggressive non-Hodgkin lymphoma of Waldeyer's ring. Am J Clin Oncol. 32(3):233-7, 2009
                                                                                                  8. Mawardi H et al: Medical management update: Non-Hodgkin lymphoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 107(1):e19-33, 2009
                                                                                                  9. Aiken AH et al: Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am. 46(2):363-78, ix-x, 2008
                                                                                                  10. Laskar S et al: Non-Hodgkin lymphoma of the Waldeyer's ring: clinicopathologic and therapeutic issues. Leuk Lymphoma. 49(12):2263-71, 2008
                                                                                                  11. Roh JL et al: Lymphomas of the head and neck in the pediatric population. Int J Pediatr Otorhinolaryngol. 71(9):1471-7, 2007
                                                                                                  12. Arias-Mendoza F et al: In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. NMR Biomed. 19(4):504-12, 2006
                                                                                                  13. Mendenhall WM et al: Lethal midline granuloma-nasal natural killer/T-cell lymphoma. Am J Clin Oncol. 29(2):202-6, 2006
                                                                                                  14. Shine NP et al: Extranodal lymphoma: clinical presentation and diagnostic pitfalls. Hosp Med. 66(6):341-5, 2005
                                                                                                  15. King AD et al: Non-Hodgkin lymphoma of the larynx: CT and MR imaging findings. AJNR Am J Neuroradiol. 25(1):12-5, 2004
                                                                                                  16. Banthia V et al: Sporadic Burkitt's lymphoma of the head and neck in the pediatric population. Int J Pediatr Otorhinolaryngol. 67(1):59-65, 2003
                                                                                                  17. Gordin A et al: Extension of nasopharyngeal lymphoma to the middle and external ear. Ann Otol Rhinol Laryngol. 112(7):644-6, 2003
                                                                                                  18. Gurkaynak M et al: Waldeyer's ring lymphomas: treatment results and prognostic factors. Am J Clin Oncol. 26(5):437-40, 2003
                                                                                                  19. Gustavsson A et al: A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma. Acta Oncol. 42(5-6):605-19, 2003
                                                                                                  20. King AD et al: Non-Hodgkin's lymphoma of the nasopharynx: CT and MR imaging. Clin Radiol. 58(8):621-5, 2003
                                                                                                  21. Prades E et al: Extranodal lymphoma originating from mucosa-associated lymphoid tissue of the nasopharynx. Acta Otolaryngol. 123(9):1098-101, 2003
                                                                                                  22. Suefuji H et al: HTLV-1 carriers with B-cell lymphoma of localized stage head and neck: prognosis, clinical and immunopathological features. Br J Haematol. 123(4):606-12, 2003
                                                                                                  23. Weber AL et al: Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 13(3):371-92, 2003
                                                                                                  24. Urquhart AC et al: Distinguishing non-Hodgkin lymphoma from squamous cell carcinoma tumors of the head and neck by computed tomography parameters. Laryngoscope. 112(6):1079-83, 2002
                                                                                                  25. Vargas H et al: Posttransplant lymphoproliferative disorder of the nasopharynx. Am J Rhinol. 16(1):37-42, 2002
                                                                                                  26. Vicente-Barrero M et al: Non-Hodgkin lymphomas of oral cavity. Vojnosanit Pregl. 59(6):669-73, 2002
                                                                                                  27. Urquhart A et al: Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 111(9):1565-9, 2001
                                                                                                  28. King AD et al: MR imaging of nasal T-cell/natural killer cell lymphoma. AJR Am J Roentgenol. 174(1):209-11, 2000
                                                                                                  29. Liang R: Diagnosis and management of primary nasal lymphoma of T-cell or NK-cell origin. Clin Lymphoma. 1(1):33-7; discussion 38, 2000
                                                                                                  30. Ooi GC et al: Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol. 174(4):1141-5, 2000
                                                                                                  31. Yaris N et al: Nasal-paranasal-oronasopharyngeal lymphomas in childhood: the role of staging system on prognosis. Pediatr Hematol Oncol. 17(5):345-53, 2000
                                                                                                  32. Ascoli V et al: Extranodal lymphomas associated with hepatitis C virus infection. Am J Clin Pathol. 109(5):600-9, 1998
                                                                                                  33. Cheung MM et al: Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients. J Clin Oncol. 16(1):70-7, 1998
                                                                                                  34. Hanna E et al: Extranodal lymphomas of the head and neck. A 20-year experience. Arch Otolaryngol Head Neck Surg. 123(12):1318-23, 1997