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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Non-Hodgkin lymphoma (NHL)
Definitions
- Lymphoma is malignant tumor of hematopoietic system that results in proliferation of lymphoid cells
- All lymphomas designated Hodgkin (HL) or NHL
- HL: Neoplastic Reed-Sternberg cells with mixed inflammatory cell mass
- NHL: Multiple subtypes of B-cell, T-cell, or NK-cell lymphomas/leukemias
- Diffuse large B cell (DLBCL) most common (30%)
- NHL of head and neck consists of 3 main forms
- Nodal
- Nonnodal lymphatic (Waldeyer's ring: Palatine and lingual tonsils and adenoids)
- Extralymphatic (e.g., soft tissues, thyroid, sinuses)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Eriksen PRG et al: Sinonasal B-cell lymphomas: a nationwide cohort study, with an emphasis on the prognosis and the recurrence pattern of primary diffuse large B-cell lymphoma. Hematol Oncol. ePub, 2022
- Ferry JA: Update from the 5th edition of the World Health Organization classification of head and neck tumors: hematolymphoid proliferations and neoplasia. Head Neck Pathol. ePub, 2022
- Yan S et al: Analysis of the clinicopathologic characteristics and prognosis of head and neck lymphoma. Anal Cell Pathol (Amst). 2022:4936099, 2022
- Kamiński B: Lymphomas of the head-and-neck region. J Cancer Res Ther. 17(6):1347-50, 2021
- Ko KWS et al: Imaging of head and neck mucosa-associated lymphoid tissue lymphoma (MALToma). Cancer Imaging. 21(1):10, 2021
- Nair R et al: Diffuse large B-cell lymphoma: clinical presentation and treatment outcomes from the OncoCollect Lymphoma Registry. Front Oncol. 11:796962, 2021
- Singh R et al: Non-Hodgkin's lymphoma: a review. J Family Med Prim Care. 9(4):1834-40, 2020
- Cakmak PG et al: Extranodal lymphoma of the head and neck: a pictorial essay. Radiol Bras. 52(4):268-71, 2019
- Storck K et al: Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med. 15(1):1, 2019
- Swerdlow SH et al: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. 127(20):2375-90, 2016
- Takano S et al: Site-specific analysis of B-cell non-Hodgkin's lymphomas of the head and neck: a retrospective 10-year observation. Acta Otolaryngol. 1-4, 2015
- Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
- Paes FM et al: FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 30(1):269-91, 2010
- Weiler-Sagie M et al: (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 51(1):25-30, 2010
- Gaini RM et al: Lymphomas of head and neck in pediatric patients. Int J Pediatr Otorhinolaryngol. 73 Suppl 1:S65-70, 2009
- Abramson SJ et al: Imaging of pediatric lymphomas. Radiol Clin North Am. 46(2):313-38, ix, 2008
- Cheson BD: New staging and response criteria for non-Hodgkin lymphoma and Hodgkin lymphoma. Radiol Clin North Am. 46(2):213-23, vii, 2008
- Haque S et al: Imaging of lymphoma of the central nervous system, spine, and orbit. Radiol Clin North Am. 46(2):339-61, ix, 2008
- Matasar MJ et al: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46(2):175-98, vii, 2008
- Swerdlow SH et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. IARC Press. 158-66, 2008
- Armitage JO: Staging non-Hodgkin lymphoma. CA Cancer J Clin. 55(6):368-76, 2005
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Non-Hodgkin lymphoma (NHL)
Definitions
- Lymphoma is malignant tumor of hematopoietic system that results in proliferation of lymphoid cells
- All lymphomas designated Hodgkin (HL) or NHL
- HL: Neoplastic Reed-Sternberg cells with mixed inflammatory cell mass
- NHL: Multiple subtypes of B-cell, T-cell, or NK-cell lymphomas/leukemias
- Diffuse large B cell (DLBCL) most common (30%)
- NHL of head and neck consists of 3 main forms
- Nodal
- Nonnodal lymphatic (Waldeyer's ring: Palatine and lingual tonsils and adenoids)
- Extralymphatic (e.g., soft tissues, thyroid, sinuses)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Eriksen PRG et al: Sinonasal B-cell lymphomas: a nationwide cohort study, with an emphasis on the prognosis and the recurrence pattern of primary diffuse large B-cell lymphoma. Hematol Oncol. ePub, 2022
- Ferry JA: Update from the 5th edition of the World Health Organization classification of head and neck tumors: hematolymphoid proliferations and neoplasia. Head Neck Pathol. ePub, 2022
- Yan S et al: Analysis of the clinicopathologic characteristics and prognosis of head and neck lymphoma. Anal Cell Pathol (Amst). 2022:4936099, 2022
- Kamiński B: Lymphomas of the head-and-neck region. J Cancer Res Ther. 17(6):1347-50, 2021
- Ko KWS et al: Imaging of head and neck mucosa-associated lymphoid tissue lymphoma (MALToma). Cancer Imaging. 21(1):10, 2021
- Nair R et al: Diffuse large B-cell lymphoma: clinical presentation and treatment outcomes from the OncoCollect Lymphoma Registry. Front Oncol. 11:796962, 2021
- Singh R et al: Non-Hodgkin's lymphoma: a review. J Family Med Prim Care. 9(4):1834-40, 2020
- Cakmak PG et al: Extranodal lymphoma of the head and neck: a pictorial essay. Radiol Bras. 52(4):268-71, 2019
- Storck K et al: Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med. 15(1):1, 2019
- Swerdlow SH et al: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. 127(20):2375-90, 2016
- Takano S et al: Site-specific analysis of B-cell non-Hodgkin's lymphomas of the head and neck: a retrospective 10-year observation. Acta Otolaryngol. 1-4, 2015
- Cheson BD et al: Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 32(27):3059-68, 2014
- Paes FM et al: FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 30(1):269-91, 2010
- Weiler-Sagie M et al: (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 51(1):25-30, 2010
- Gaini RM et al: Lymphomas of head and neck in pediatric patients. Int J Pediatr Otorhinolaryngol. 73 Suppl 1:S65-70, 2009
- Abramson SJ et al: Imaging of pediatric lymphomas. Radiol Clin North Am. 46(2):313-38, ix, 2008
- Cheson BD: New staging and response criteria for non-Hodgkin lymphoma and Hodgkin lymphoma. Radiol Clin North Am. 46(2):213-23, vii, 2008
- Haque S et al: Imaging of lymphoma of the central nervous system, spine, and orbit. Radiol Clin North Am. 46(2):339-61, ix, 2008
- Matasar MJ et al: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46(2):175-98, vii, 2008
- Swerdlow SH et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. IARC Press. 158-66, 2008
- Armitage JO: Staging non-Hodgkin lymphoma. CA Cancer J Clin. 55(6):368-76, 2005
