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Non-Small Cell Lung Cancer
Bhavana Budigi, MD; Anita Thomas, MD; Paige Bennett, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Diagnostic Checklist

        TERMINOLOGY

        • Definitions

          • Non-small cell lung cancer (NSCLC)
            • Most common type of lung cancer, arising from secretory cells
            • Accounts for 84% of all lung cancers
            • Squamous cell carcinoma, large cell carcinoma, adenocarcinoma, and adenocarcinoma in situ

        IMAGING

        • General Features

          • Nuclear Medicine Findings

            DIFFERENTIAL DIAGNOSIS

              PATHOLOGY

              • General Features

                • Microscopic Features

                  CLINICAL ISSUES

                  • Presentation

                    • Demographics

                      • Natural History & Prognosis

                        • Treatment

                          • Surgery

                            • Combined Chemoradiation

                              • Systemic Therapy

                                • Radiation Therapy

                                  DIAGNOSTIC CHECKLIST

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Brodin NP et al: 18F-fluorodeoxyglucose PET in locally advanced non-small cell lung cancer: From predicting outcomes to guiding therapy. PET Clin. 15(1):55-63, 2020
                                    2. Kim H et al: Clinical T category of non-small cell lung cancers: Prognostic performance of unidimensional versus bidimensional measurements at CT. Radiology. 290(3):807-13, 2019
                                    3. Detterbeck FC: The eighth edition TNM stage classification for lung cancer: What does it mean on main street? J Thorac Cardiovasc Surg. 155(1):356-9, 2018
                                    4. Kandathil A et al: Role of FDG PET/CT in the eighth edition of TNM staging of non-small cell lung cancer. Radiographics. 38(7):2134-49, 2018
                                    5. Bhatkar D et al: Dual Tracer PET Imaging (68Ga-DOTATATE and 18F-FDG) Features in Pulmonary Carcinoid: Correlation with Tumor Proliferation Index. Indian J Nucl Med. 32(1):39-41, 2017
                                    6. Greenspan BS: Role of PET/CT for precision medicine in lung cancer: perspective of the Society of Nuclear Medicine and Molecular Imaging. Transl Lung Cancer Res. 6(6):617-620, 2017
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Definitions

                                            • Non-small cell lung cancer (NSCLC)
                                              • Most common type of lung cancer, arising from secretory cells
                                              • Accounts for 84% of all lung cancers
                                              • Squamous cell carcinoma, large cell carcinoma, adenocarcinoma, and adenocarcinoma in situ

                                          IMAGING

                                          • General Features

                                            • Nuclear Medicine Findings

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • General Features

                                                  • Microscopic Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            • Surgery

                                                              • Combined Chemoradiation

                                                                • Systemic Therapy

                                                                  • Radiation Therapy

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Brodin NP et al: 18F-fluorodeoxyglucose PET in locally advanced non-small cell lung cancer: From predicting outcomes to guiding therapy. PET Clin. 15(1):55-63, 2020
                                                                      2. Kim H et al: Clinical T category of non-small cell lung cancers: Prognostic performance of unidimensional versus bidimensional measurements at CT. Radiology. 290(3):807-13, 2019
                                                                      3. Detterbeck FC: The eighth edition TNM stage classification for lung cancer: What does it mean on main street? J Thorac Cardiovasc Surg. 155(1):356-9, 2018
                                                                      4. Kandathil A et al: Role of FDG PET/CT in the eighth edition of TNM staging of non-small cell lung cancer. Radiographics. 38(7):2134-49, 2018
                                                                      5. Bhatkar D et al: Dual Tracer PET Imaging (68Ga-DOTATATE and 18F-FDG) Features in Pulmonary Carcinoid: Correlation with Tumor Proliferation Index. Indian J Nucl Med. 32(1):39-41, 2017
                                                                      6. Greenspan BS: Role of PET/CT for precision medicine in lung cancer: perspective of the Society of Nuclear Medicine and Molecular Imaging. Transl Lung Cancer Res. 6(6):617-620, 2017