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Nonneoplastic Pancreatic Cysts
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Congenital, true, or epithelial pancreatic cyst
            • Definitions

              • Group of nonneoplastic, noninflammatory, benign pancreatic cysts comprising several different histopathologic entities

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Radiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Komura T et al: Imaging features and pathological evaluation by EUS-FNA enable conservative management in patient of lymphoepithelial cyst of the pancreas: a case report. Clin J Gastroenterol. 14(1):370-4, 2020
                                            2. Patel N et al: Pancreatic Cysts. StatPearls [Internet]. StatPearls Publishing, 2021
                                            3. Groot VP et al: Lessons learned from 29 lymphoepithelial cysts of the pancreas: institutional experience and review of the literature. HPB (Oxford). 20(7):612-20, 2018
                                            4. Tanaka M et al: Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology. 17(5):738-53, 2017
                                            5. Al-Salem AH et al: Congenital pancreatic cyst: diagnosis and management. J Pediatr Gastroenterol Nutr. 59(4):e38-40, 2014
                                            6. Assifi MM et al: Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity. J Gastrointest Surg. 18(3):523-31, 2014
                                            7. Kim WH et al: Lymphoepithelial cyst of the pancreas: comparison of CT findings with other pancreatic cystic lesions. Abdom Imaging. 38(2):324-30, 2013
                                            8. Osiro S et al: Is preoperative diagnosis possible? A clinical and radiological review of lymphoepithelial cysts of the pancreas. JOP. 14(1):15-20, 2013
                                            9. de Castro SM et al: Evaluation of a selective management strategy of patients with primary cystic neoplasms of the pancreas. Int J Surg. 9(8):655-8, 2011
                                            10. Johnson PT et al: Common incidental findings on MDCT: survey of radiologist recommendations for patient management. J Am Coll Radiol. 8(11):762-7, 2011
                                            11. Megibow AJ et al: The incidental pancreatic cyst. Radiol Clin North Am. 49(2):349-59, 2011
                                            12. Molvar C et al: Nonneoplastic cystic lesions of pancreas: a practical clinical, histologic, and radiologic approach. Curr Probl Diagn Radiol. 40(4):141-8, 2011
                                            13. Wellner UF et al: Incidental cystic tumor in the pancreas: observe or operate? Gastroenterology. 140(5):e1-2, 2011
                                            14. Berland LL et al: Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee. J Am Coll Radiol. 7(10):754-73, 2010
                                            15. Federle et al: Diagnostic Imaging: Abdomen. 2nd edition. Salt Lake City: Amirsys, 2010
                                            16. Carboni F et al: Solitary true cyst of the pancreas in adults. A report of two cases. JOP. 10(4):429-31, 2009
                                            17. Ahlawat SK: Lymphoepithelial cyst of pancreas. Role of endoscopic ultrasound guided fine needle aspiration. JOP. 9(2):230-4, 2008
                                            18. Goh BK et al: Non-neoplastic cystic and cystic-like lesions of the pancreas: may mimic pancreatic cystic neoplasms. ANZ J Surg. 76(5):325-31, 2006
                                            19. Mukhopadhyay B et al: Pancreatic lesions in von Hippel-Lindau disease. Clin Endocrinol (Oxf). 57(5):603-8, 2002
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • Congenital, true, or epithelial pancreatic cyst
                                                      • Definitions

                                                        • Group of nonneoplastic, noninflammatory, benign pancreatic cysts comprising several different histopathologic entities

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Radiographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Komura T et al: Imaging features and pathological evaluation by EUS-FNA enable conservative management in patient of lymphoepithelial cyst of the pancreas: a case report. Clin J Gastroenterol. 14(1):370-4, 2020
                                                                                      2. Patel N et al: Pancreatic Cysts. StatPearls [Internet]. StatPearls Publishing, 2021
                                                                                      3. Groot VP et al: Lessons learned from 29 lymphoepithelial cysts of the pancreas: institutional experience and review of the literature. HPB (Oxford). 20(7):612-20, 2018
                                                                                      4. Tanaka M et al: Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology. 17(5):738-53, 2017
                                                                                      5. Al-Salem AH et al: Congenital pancreatic cyst: diagnosis and management. J Pediatr Gastroenterol Nutr. 59(4):e38-40, 2014
                                                                                      6. Assifi MM et al: Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity. J Gastrointest Surg. 18(3):523-31, 2014
                                                                                      7. Kim WH et al: Lymphoepithelial cyst of the pancreas: comparison of CT findings with other pancreatic cystic lesions. Abdom Imaging. 38(2):324-30, 2013
                                                                                      8. Osiro S et al: Is preoperative diagnosis possible? A clinical and radiological review of lymphoepithelial cysts of the pancreas. JOP. 14(1):15-20, 2013
                                                                                      9. de Castro SM et al: Evaluation of a selective management strategy of patients with primary cystic neoplasms of the pancreas. Int J Surg. 9(8):655-8, 2011
                                                                                      10. Johnson PT et al: Common incidental findings on MDCT: survey of radiologist recommendations for patient management. J Am Coll Radiol. 8(11):762-7, 2011
                                                                                      11. Megibow AJ et al: The incidental pancreatic cyst. Radiol Clin North Am. 49(2):349-59, 2011
                                                                                      12. Molvar C et al: Nonneoplastic cystic lesions of pancreas: a practical clinical, histologic, and radiologic approach. Curr Probl Diagn Radiol. 40(4):141-8, 2011
                                                                                      13. Wellner UF et al: Incidental cystic tumor in the pancreas: observe or operate? Gastroenterology. 140(5):e1-2, 2011
                                                                                      14. Berland LL et al: Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee. J Am Coll Radiol. 7(10):754-73, 2010
                                                                                      15. Federle et al: Diagnostic Imaging: Abdomen. 2nd edition. Salt Lake City: Amirsys, 2010
                                                                                      16. Carboni F et al: Solitary true cyst of the pancreas in adults. A report of two cases. JOP. 10(4):429-31, 2009
                                                                                      17. Ahlawat SK: Lymphoepithelial cyst of pancreas. Role of endoscopic ultrasound guided fine needle aspiration. JOP. 9(2):230-4, 2008
                                                                                      18. Goh BK et al: Non-neoplastic cystic and cystic-like lesions of the pancreas: may mimic pancreatic cystic neoplasms. ANZ J Surg. 76(5):325-31, 2006
                                                                                      19. Mukhopadhyay B et al: Pancreatic lesions in von Hippel-Lindau disease. Clin Endocrinol (Oxf). 57(5):603-8, 2002