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Nonossifying Fibroma
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Nonossifying fibroma (NOF)
            • Synonyms

              • Fibroxanthoma, fibrous cortical defect (FCD), nonosteogenic fibroma, metaphyseal fibrous defect, histiocytic xanthogranuloma, benign fibrous histiocytoma
            • Definitions

              • Benign and generally self-limiting spindle cell tumor of bone containing osteoclast-like giant cells

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Reporting Tips

                                        Selected References

                                        1. Baumhoer D et al: Non-ossifying fibroma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 447-8, 2020
                                        2. Goldin AN et al: Nonossifying fibromas: a computed tomography-based criteria to predict fracture risk. J Pediatr Orthop. 40(2):e149-54, 2020
                                        3. Sakamoto A et al: Non-ossifying fibromas: case series, including in uncommon upper extremity sites. World J Orthop. 8(7):561-6, 2017
                                        4. Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
                                        5. Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
                                        6. Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
                                        7. von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
                                        8. Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
                                        9. Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
                                        10. Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
                                        11. Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
                                        12. Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
                                        13. Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Lippincott-Raven. 205-9, 1998
                                        14. Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Nonossifying fibroma (NOF)
                                                  • Synonyms

                                                    • Fibroxanthoma, fibrous cortical defect (FCD), nonosteogenic fibroma, metaphyseal fibrous defect, histiocytic xanthogranuloma, benign fibrous histiocytoma
                                                  • Definitions

                                                    • Benign and generally self-limiting spindle cell tumor of bone containing osteoclast-like giant cells

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Reporting Tips

                                                                              Selected References

                                                                              1. Baumhoer D et al: Non-ossifying fibroma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 447-8, 2020
                                                                              2. Goldin AN et al: Nonossifying fibromas: a computed tomography-based criteria to predict fracture risk. J Pediatr Orthop. 40(2):e149-54, 2020
                                                                              3. Sakamoto A et al: Non-ossifying fibromas: case series, including in uncommon upper extremity sites. World J Orthop. 8(7):561-6, 2017
                                                                              4. Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
                                                                              5. Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
                                                                              6. Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
                                                                              7. von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
                                                                              8. Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
                                                                              9. Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
                                                                              10. Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
                                                                              11. Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
                                                                              12. Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
                                                                              13. Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Lippincott-Raven. 205-9, 1998
                                                                              14. Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998