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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Nonossifying fibroma (NOF)
Synonyms
- Fibroxanthoma, fibrous cortical defect (FCD), nonosteogenic fibroma, metaphyseal fibrous defect, histiocytic xanthogranuloma, benign fibrous histiocytoma
Definitions
- Benign and generally self-limiting spindle cell tumor of bone containing osteoclast-like giant cells
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
- Baumhoer D et al: Non-ossifying fibroma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 447-8, 2020
- Goldin AN et al: Nonossifying fibromas: a computed tomography-based criteria to predict fracture risk. J Pediatr Orthop. 40(2):e149-54, 2020
- Sakamoto A et al: Non-ossifying fibromas: case series, including in uncommon upper extremity sites. World J Orthop. 8(7):561-6, 2017
- Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
- Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
- Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
- von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
- Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
- Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
- Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
- Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
- Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
- Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Lippincott-Raven. 205-9, 1998
- Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Nonossifying fibroma (NOF)
Synonyms
- Fibroxanthoma, fibrous cortical defect (FCD), nonosteogenic fibroma, metaphyseal fibrous defect, histiocytic xanthogranuloma, benign fibrous histiocytoma
Definitions
- Benign and generally self-limiting spindle cell tumor of bone containing osteoclast-like giant cells
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Reporting Tips
Selected References
- Baumhoer D et al: Non-ossifying fibroma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 447-8, 2020
- Goldin AN et al: Nonossifying fibromas: a computed tomography-based criteria to predict fracture risk. J Pediatr Orthop. 40(2):e149-54, 2020
- Sakamoto A et al: Non-ossifying fibromas: case series, including in uncommon upper extremity sites. World J Orthop. 8(7):561-6, 2017
- Wadhwa V et al: Enlarging nonossifying fibroma mimicking aggressive bone tumour. Indian J Cancer. 50(4):301, 2013
- Sakamoto A et al: Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner. J Orthop Sports Phys Ther. 38(7):434-8, 2008
- Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
- von Falck C et al: Nonossifying fibroma can mimic residual lymphoma in FDG PET: additional value of combined PET/CT. Clin Nucl Med. 32(8):640-2, 2007
- Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
- Drubach LA et al: Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med. 29(1):41-2, 2004
- Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
- Nelson M et al: Translocation (1;4)(p31;q34) in nonossifying fibroma. Cancer Genet Cytogenet. 142(2):142-4, 2003
- Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
- Greenspan A et al: Differential Diagnosis of Tumors and Tumor-like Lesions of Bones and Joints. Lippincott-Raven. 205-9, 1998
- Jee WH et al: Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology. 209(1):197-202, 1998
