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KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Abbreviations
- Nonossifying fibroma (NOF)
Synonyms
- Non-ossifying fibroma, fibrous cortical defect (FCD), metaphyseal fibrous defect, fibroxanthoma
Definitions
- Very common benign fibrous lesion of pediatric bone, usually asymptomatic
- Terms fibroxanthoma & metaphyseal fibrous defect include
- NOF
- > 2- or 3-cm length
- Encroachment on medullary cavity
- FCD
- < 2- or 3-cm length
- Essentially isolated to cortex
- NOF
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Goldin AN et al: Nonossifying fibromas: a computed tomography-based criteria to predict fracture risk. J Pediatr Orthop. 40(2):e149-54, 2020
- Shah JN et al: Pediatric benign bone tumors: what does the radiologist need to know? Pediatric Imaging. Radiographics. 37(3):1001-2, 2017
- Wodajo FM: Top five lesions that do not need referral to orthopedic oncology. Orthop Clin North Am. 46(2):303-14, 2015
- Jagtap VS et al: Tumor-induced osteomalacia: a single center experience. Endocr Pract. 17(2):177-84, 2011
- Leong NL et al: Computed tomography-based structural analysis for predicting fracture risk in children with benign skeletal neoplasms: comparison of specificity with that of plain radiographs. J Bone Joint Surg Am. 92(9):1827-33, 2010
- Shimal A et al: Fatigue-type stress fractures of the lower limb associated with fibrous cortical defects/non-ossifying fibromas in the skeletally immature. Clin Radiol. 65(5):382-6, 2010
- Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am. 17(3):469-87, vi, 2009
- Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
- Hod N et al: Scintigraphic characteristics of non-ossifying fibroma in military recruits undergoing bone scintigraphy for suspected stress fractures and lower limb pains. Nucl Med Commun. 28(1):25-33, 2007
- Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
- Iagaru A et al: PET/CT follow-up in nonossifying fibroma. AJR Am J Roentgenol. 187(3):830-2, 2006
- Huzjan R et al: The value of ultrasound in diagnosis and follow-up of fibrous cortical defect. Ultraschall Med. 26(5):420-3, 2005
- Colby RS et al: Is Jaffe-Campanacci syndrome just a manifestation of neurofibromatosis type 1? Am J Med Genet A. 123(1):60-3, 2003
- Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
- Loberant N et al: Gray-scale and Doppler characteristics of fibrous cortical defects in a child. J Clin Ultrasound. 31(7):369-74, 2003
- Yanagawa T et al: The natural history of disappearing bone tumours and tumour-like conditions. Clin Radiol. 56(11):877-86, 2001
- Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
- Suginoshita T et al: Case report: natural development of osteosarcoma from precancerous lesion. Anticancer Res. 20(1B):511-4, 2000
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Abbreviations
- Nonossifying fibroma (NOF)
Synonyms
- Non-ossifying fibroma, fibrous cortical defect (FCD), metaphyseal fibrous defect, fibroxanthoma
Definitions
- Very common benign fibrous lesion of pediatric bone, usually asymptomatic
- Terms fibroxanthoma & metaphyseal fibrous defect include
- NOF
- > 2- or 3-cm length
- Encroachment on medullary cavity
- FCD
- < 2- or 3-cm length
- Essentially isolated to cortex
- NOF
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Goldin AN et al: Nonossifying fibromas: a computed tomography-based criteria to predict fracture risk. J Pediatr Orthop. 40(2):e149-54, 2020
- Shah JN et al: Pediatric benign bone tumors: what does the radiologist need to know? Pediatric Imaging. Radiographics. 37(3):1001-2, 2017
- Wodajo FM: Top five lesions that do not need referral to orthopedic oncology. Orthop Clin North Am. 46(2):303-14, 2015
- Jagtap VS et al: Tumor-induced osteomalacia: a single center experience. Endocr Pract. 17(2):177-84, 2011
- Leong NL et al: Computed tomography-based structural analysis for predicting fracture risk in children with benign skeletal neoplasms: comparison of specificity with that of plain radiographs. J Bone Joint Surg Am. 92(9):1827-33, 2010
- Shimal A et al: Fatigue-type stress fractures of the lower limb associated with fibrous cortical defects/non-ossifying fibromas in the skeletally immature. Clin Radiol. 65(5):382-6, 2010
- Wootton-Gorges SL: MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am. 17(3):469-87, vi, 2009
- Hetts SW et al: Case 110: Nonossifying fibroma. Radiology. 243(1):288-92, 2007
- Hod N et al: Scintigraphic characteristics of non-ossifying fibroma in military recruits undergoing bone scintigraphy for suspected stress fractures and lower limb pains. Nucl Med Commun. 28(1):25-33, 2007
- Goodin GS et al: PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006 Oct;187(4):1124-8. Erratum in: AJR Am J Roentgenol. 187(5):1146, 2006
- Iagaru A et al: PET/CT follow-up in nonossifying fibroma. AJR Am J Roentgenol. 187(3):830-2, 2006
- Huzjan R et al: The value of ultrasound in diagnosis and follow-up of fibrous cortical defect. Ultraschall Med. 26(5):420-3, 2005
- Colby RS et al: Is Jaffe-Campanacci syndrome just a manifestation of neurofibromatosis type 1? Am J Med Genet A. 123(1):60-3, 2003
- Levine SM et al: Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics. 23(1):157-77, 2003
- Loberant N et al: Gray-scale and Doppler characteristics of fibrous cortical defects in a child. J Clin Ultrasound. 31(7):369-74, 2003
- Yanagawa T et al: The natural history of disappearing bone tumours and tumour-like conditions. Clin Radiol. 56(11):877-86, 2001
- Smith SE et al: Primary musculoskeletal tumors of fibrous origin. Semin Musculoskelet Radiol. 4(1):73-88, 2000
- Suginoshita T et al: Case report: natural development of osteosarcoma from precancerous lesion. Anticancer Res. 20(1B):511-4, 2000
