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Nonseminomatous Germ Cell Neoplasms of the Mediastinum
Terrance Healey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Malignant germ cell neoplasm (MGCN)
              • Definitions

                • Primary mediastinal MGCN
                  • Yolk sac (endodermal sinus) tumor
                  • Choriocarcinoma
                  • Embryonal carcinoma
                  • Mixed type germ cell neoplasm

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • PET/CT

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Gillian TD, Kantoff PW: Extragonadal germ cell tumors involving the mediastinum and retroperitoneum. Uptodate.com. accessed 7/14/2011
                                              2. Fedyanin M et al: Prognostic factors and efficacy of different chemotherapeutic regimens in patients with mediastinal nonseminomatous germ cell tumors. J Cancer Res Clin Oncol. 140(2):311-8, 2014
                                              3. Fukui N et al: Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. Int J Clin Oncol. 18(4):731-4, 2013
                                              4. Ueno T et al: Spectrum of germ cell tumors: from head to toe. Radiographics. 24(2):387-404, 2004
                                              5. Rosado-de-Christenson ML et al: From the archives of the AFIP. Mediastinal germ cell tumors: radiologic and pathologic correlation. Radiographics. 12(5):1013-30, 1992
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Malignant germ cell neoplasm (MGCN)
                                                          • Definitions

                                                            • Primary mediastinal MGCN
                                                              • Yolk sac (endodermal sinus) tumor
                                                              • Choriocarcinoma
                                                              • Embryonal carcinoma
                                                              • Mixed type germ cell neoplasm

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • PET/CT

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Gillian TD, Kantoff PW: Extragonadal germ cell tumors involving the mediastinum and retroperitoneum. Uptodate.com. accessed 7/14/2011
                                                                                          2. Fedyanin M et al: Prognostic factors and efficacy of different chemotherapeutic regimens in patients with mediastinal nonseminomatous germ cell tumors. J Cancer Res Clin Oncol. 140(2):311-8, 2014
                                                                                          3. Fukui N et al: Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. Int J Clin Oncol. 18(4):731-4, 2013
                                                                                          4. Ueno T et al: Spectrum of germ cell tumors: from head to toe. Radiographics. 24(2):387-404, 2004
                                                                                          5. Rosado-de-Christenson ML et al: From the archives of the AFIP. Mediastinal germ cell tumors: radiologic and pathologic correlation. Radiographics. 12(5):1013-30, 1992