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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Nonspecific interstitial pneumonia (NSIP)
Definitions
- Type of idiopathic interstitial pneumonia (IIP)
- Chronic fibrosing IIPs
- Idiopathic pulmonary fibrosis (IPF)
- Idiopathic NSIP
- Rare IIPs
- Lymphoid interstitial pneumonia
- Idiopathic pleuroparenchymal fibroelastosis
- Smoking-related IIPs
- Desquamative interstitial pneumonia
- Respiratory bronchiolitis-interstitial lung disease
- Acute or subacute IIPs
- Cryptogenic organizing pneumonia (OP)
- Acute interstitial pneumonia
- NSIP may be idiopathic or may be associated with connective tissue/autoimmune disease, drug toxicity, hypersensitivity pneumonitis, and other etiologies
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Johkoh T et al: Chest CT diagnosis and clinical management of drug-related pneumonitis in patients receiving molecular targeting agents and immune checkpoint inhibitors: a position paper from the Fleischner Society. Radiology. 298(3):550-66, 2021
- Hatabu H et al: Expanding applications of pulmonary mri in the clinical evaluation of lung disorders: Fleischner Society position paper. Radiology. 297(2):286-301, 2020
- Teoh AKY et al: Nonspecific interstitial pneumonia. Semin Respir Crit Care Med. 41(2):184-201, 2020
- Graney BA et al: Interstitial pneumonia with autoimmune features. Ann Am Thorac Soc. 16(5):525-33, 2019
- Zhan X et al: Differentiating usual interstitial pneumonia from nonspecific interstitial pneumonia using high-resolution computed tomography: the "straight-edge sign". J Thorac Imaging. 33(4):266-70, 2018
- Chung JH et al: CT findings, radiologic-pathologic correlation, and imaging predictors of survival for patients with interstitial pneumonia with autoimmune features. AJR Am J Roentgenol. 208(6):1229-36, 2017
- Huo Z et al: Organizing pneumonia components in non-specific interstitial pneumonia (NSIP): a clinicopathological study of 33 NSIP cases. Histopathology. 68(3):347-55, 2016
- Buzan MT et al: T2 mapping of CT remodelling patterns in interstitial lung disease. Eur Radiol. 25(11):3167-74, 2015
- Fischer A et al: An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. Eur Respir J. 46(4):976-87, 2015
- Sverzellati N et al: American Thoracic Society-European Respiratory Society classification of the idiopathic interstitial pneumonias: advances in knowledge since 2002. Radiographics. 35(7):1849-71, 2015
- Todd NW et al: Organizing pneumonia/non-specific interstitial pneumonia overlap is associated with unfavorable lung disease progression. Respir Med. 109(11):1460-8, 2015
- Travis WD et al: An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 188(6):733-48, 2013
- Lee HY et al: High-resolution CT findings in fibrotic idiopathic interstitial pneumonias with little honeycombing: serial changes and prognostic implications. AJR Am J Roentgenol. 199(5):982-9, 2012
- Raghu G et al: An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 183(6):788-824, 2011
- Lee JW et al: Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. AJR Am J Roentgenol. 195(4):916-22, 2010
- Kligerman SJ, et al: Nonspecific interstitial pneumonia: radiologic, clinical, and pathologic considerations. Radiographics: 29(1):73-87, 2009
- Silva CI et al: Nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis: changes in pattern and distribution of disease over time. Radiology. 247(1):251-9, 2008
- Silva CI et al: Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 246(1):288-97, 2008
- Yi CA et al: 3-T MRI for differentiating inflammation- and fibrosis-predominant lesions of usual and nonspecific interstitial pneumonia: comparison study with pathologic correlation. AJR Am J Roentgenol. 190(4):878-85, 2008
- Kim EY, Lee KS, Chung MP, Kwon OJ, Kim TS, Hwang JH. Nonspecific interstitial pneumonia with fibrosis: serial high-resolution CT findings with functional correlation. AJR 1999;173:949–53.
- Park JS et al: Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients. Radiology. 195(3):645-8, 1995
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Nonspecific interstitial pneumonia (NSIP)
Definitions
- Type of idiopathic interstitial pneumonia (IIP)
- Chronic fibrosing IIPs
- Idiopathic pulmonary fibrosis (IPF)
- Idiopathic NSIP
- Rare IIPs
- Lymphoid interstitial pneumonia
- Idiopathic pleuroparenchymal fibroelastosis
- Smoking-related IIPs
- Desquamative interstitial pneumonia
- Respiratory bronchiolitis-interstitial lung disease
- Acute or subacute IIPs
- Cryptogenic organizing pneumonia (OP)
- Acute interstitial pneumonia
- NSIP may be idiopathic or may be associated with connective tissue/autoimmune disease, drug toxicity, hypersensitivity pneumonitis, and other etiologies
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Johkoh T et al: Chest CT diagnosis and clinical management of drug-related pneumonitis in patients receiving molecular targeting agents and immune checkpoint inhibitors: a position paper from the Fleischner Society. Radiology. 298(3):550-66, 2021
- Hatabu H et al: Expanding applications of pulmonary mri in the clinical evaluation of lung disorders: Fleischner Society position paper. Radiology. 297(2):286-301, 2020
- Teoh AKY et al: Nonspecific interstitial pneumonia. Semin Respir Crit Care Med. 41(2):184-201, 2020
- Graney BA et al: Interstitial pneumonia with autoimmune features. Ann Am Thorac Soc. 16(5):525-33, 2019
- Zhan X et al: Differentiating usual interstitial pneumonia from nonspecific interstitial pneumonia using high-resolution computed tomography: the "straight-edge sign". J Thorac Imaging. 33(4):266-70, 2018
- Chung JH et al: CT findings, radiologic-pathologic correlation, and imaging predictors of survival for patients with interstitial pneumonia with autoimmune features. AJR Am J Roentgenol. 208(6):1229-36, 2017
- Huo Z et al: Organizing pneumonia components in non-specific interstitial pneumonia (NSIP): a clinicopathological study of 33 NSIP cases. Histopathology. 68(3):347-55, 2016
- Buzan MT et al: T2 mapping of CT remodelling patterns in interstitial lung disease. Eur Radiol. 25(11):3167-74, 2015
- Fischer A et al: An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. Eur Respir J. 46(4):976-87, 2015
- Sverzellati N et al: American Thoracic Society-European Respiratory Society classification of the idiopathic interstitial pneumonias: advances in knowledge since 2002. Radiographics. 35(7):1849-71, 2015
- Todd NW et al: Organizing pneumonia/non-specific interstitial pneumonia overlap is associated with unfavorable lung disease progression. Respir Med. 109(11):1460-8, 2015
- Travis WD et al: An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 188(6):733-48, 2013
- Lee HY et al: High-resolution CT findings in fibrotic idiopathic interstitial pneumonias with little honeycombing: serial changes and prognostic implications. AJR Am J Roentgenol. 199(5):982-9, 2012
- Raghu G et al: An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 183(6):788-824, 2011
- Lee JW et al: Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. AJR Am J Roentgenol. 195(4):916-22, 2010
- Kligerman SJ, et al: Nonspecific interstitial pneumonia: radiologic, clinical, and pathologic considerations. Radiographics: 29(1):73-87, 2009
- Silva CI et al: Nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis: changes in pattern and distribution of disease over time. Radiology. 247(1):251-9, 2008
- Silva CI et al: Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 246(1):288-97, 2008
- Yi CA et al: 3-T MRI for differentiating inflammation- and fibrosis-predominant lesions of usual and nonspecific interstitial pneumonia: comparison study with pathologic correlation. AJR Am J Roentgenol. 190(4):878-85, 2008
- Kim EY, Lee KS, Chung MP, Kwon OJ, Kim TS, Hwang JH. Nonspecific interstitial pneumonia with fibrosis: serial high-resolution CT findings with functional correlation. AJR 1999;173:949–53.
- Park JS et al: Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients. Radiology. 195(3):645-8, 1995
