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Normal Aging Brain
Miral D. Jhaveri, MD; Sheri L. Harder, MD, FRCPC
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • ↓ overall brain volume with advancing age
                • Reflected in relative ↑ CSF spaces

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Xekardaki A et al: Neuropathological changes in aging brain. Adv Exp Med Biol. 821:11-7, 2015
                                        2. van Velsen EF et al: Brain cortical thickness in the general elderly population: the Rotterdam Scan Study. Neurosci Lett. 550:189-94, 2013
                                        3. Poels MM et al: Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke. 43(10):2637-42, 2012
                                        4. Ikram MA et al: The Rotterdam Scan Study: design and update up to 2012. Eur J Epidemiol. 26(10):811-24, 2011
                                        5. Poels MM et al: Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study. Stroke. 42(3):656-61, 2011
                                        6. Ni JM et al: Regional diffusion changes of cerebral grey matter during normal aging--a fluid-inversion prepared diffusion imaging study. Eur J Radiol. 75(2):134-8, 2010
                                        7. Salat DH et al: Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage. 44(4):1247-58, 2009
                                        8. Williams LR et al: Clinical correlates of cerebral white matter hyperintensities in cognitively normal older adults. Arch Gerontol Geriatr. Epub ahead of print, 2009
                                        9. Galluzzi S et al: Aging. Neurol Sci. 29 Suppl 3:296-300, 2008
                                        10. Gruber S et al: Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. Eur J Radiol. 68(2):320-7, 2008
                                        11. Harder SL et al: Mineralization of the deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging. AJNR Am J Neuroradiol. 29(1):176-83, 2008
                                        12. Kövari E et al: Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke. 35(2):410-4, 2004
                                        13. Brickman AM et al: Striatal size, glucose metabolic rate, and verbal learning in normal aging. Brain Res Cogn Brain Res. 17(1):106-16, 2003
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • ↓ overall brain volume with advancing age
                                                      • Reflected in relative ↑ CSF spaces

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Nuclear Medicine Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Xekardaki A et al: Neuropathological changes in aging brain. Adv Exp Med Biol. 821:11-7, 2015
                                                                              2. van Velsen EF et al: Brain cortical thickness in the general elderly population: the Rotterdam Scan Study. Neurosci Lett. 550:189-94, 2013
                                                                              3. Poels MM et al: Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke. 43(10):2637-42, 2012
                                                                              4. Ikram MA et al: The Rotterdam Scan Study: design and update up to 2012. Eur J Epidemiol. 26(10):811-24, 2011
                                                                              5. Poels MM et al: Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study. Stroke. 42(3):656-61, 2011
                                                                              6. Ni JM et al: Regional diffusion changes of cerebral grey matter during normal aging--a fluid-inversion prepared diffusion imaging study. Eur J Radiol. 75(2):134-8, 2010
                                                                              7. Salat DH et al: Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage. 44(4):1247-58, 2009
                                                                              8. Williams LR et al: Clinical correlates of cerebral white matter hyperintensities in cognitively normal older adults. Arch Gerontol Geriatr. Epub ahead of print, 2009
                                                                              9. Galluzzi S et al: Aging. Neurol Sci. 29 Suppl 3:296-300, 2008
                                                                              10. Gruber S et al: Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. Eur J Radiol. 68(2):320-7, 2008
                                                                              11. Harder SL et al: Mineralization of the deep gray matter with age: a retrospective review with susceptibility-weighted MR imaging. AJNR Am J Neuroradiol. 29(1):176-83, 2008
                                                                              12. Kövari E et al: Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke. 35(2):410-4, 2004
                                                                              13. Brickman AM et al: Striatal size, glucose metabolic rate, and verbal learning in normal aging. Brain Res Cogn Brain Res. 17(1):106-16, 2003