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Normal Fatty Marrow Variants
Kevin R. Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Red marrow: Hematopoietic marrow
                • Yellow marrow: Fatty marrow

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. He J et al: Vertebral bone marrow fat content in normal adults with varying bone densities at 3T magnetic resonance imaging. Acta Radiol. 60(4):509-15, 2019
                                    2. Baum T et al: Anatomical variation of age-related changes in vertebral bone marrow composition using chemical shift encoding-based water-fat magnetic resonance imaging. Front Endocrinol (Lausanne). 9:141, 2018
                                    3. Shiran SI et al: T1-weighted MR imaging of bone marrow pattern in children with adolescent idiopathic scoliosis: a preliminary study. J Child Orthop. 12(2):181-6, 2018
                                    4. Singhal V et al: Differential associations between appendicular and axial marrow adipose tissue with bone microarchitecture in adolescents and young adults with obesity. Bone. 116:203-6, 2018
                                    5. Guillerman RP: Marrow: red, yellow and bad. Pediatr Radiol. 43 Suppl 1:S181-92, 2013
                                    6. Vande Berg BC et al: Normal variants of the bone marrow at MR imaging of the spine. Semin Musculoskelet Radiol. 13(2):87-96, 2009
                                    7. Castillo M: Diffusion-weighted imaging of the spine: is it reliable? AJNR Am J Neuroradiol. 24(6):1251-3, 2003
                                    8. Montazel JL et al: Normal spinal bone marrow in adults: dynamic gadolinium-enhanced MR imaging. Radiology. 229(3):703-9, 2003
                                    9. Otake S et al: Radiation-induced changes in MR signal intensity and contrast enhancement of lumbosacral vertebrae: do changes occur only inside the radiation therapy field? Radiology. 222(1):179-83, 2002
                                    10. Baur A et al: Diffusion-weighted magnetic resonance imaging of spinal bone marrow. Semin Musculoskelet Radiol. 5(1):35-42, 2001
                                    11. Kim HJ et al: Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging. Clin Imaging. 23(2):125-33, 1999
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Definitions

                                                  • Red marrow: Hematopoietic marrow
                                                  • Yellow marrow: Fatty marrow

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. He J et al: Vertebral bone marrow fat content in normal adults with varying bone densities at 3T magnetic resonance imaging. Acta Radiol. 60(4):509-15, 2019
                                                                      2. Baum T et al: Anatomical variation of age-related changes in vertebral bone marrow composition using chemical shift encoding-based water-fat magnetic resonance imaging. Front Endocrinol (Lausanne). 9:141, 2018
                                                                      3. Shiran SI et al: T1-weighted MR imaging of bone marrow pattern in children with adolescent idiopathic scoliosis: a preliminary study. J Child Orthop. 12(2):181-6, 2018
                                                                      4. Singhal V et al: Differential associations between appendicular and axial marrow adipose tissue with bone microarchitecture in adolescents and young adults with obesity. Bone. 116:203-6, 2018
                                                                      5. Guillerman RP: Marrow: red, yellow and bad. Pediatr Radiol. 43 Suppl 1:S181-92, 2013
                                                                      6. Vande Berg BC et al: Normal variants of the bone marrow at MR imaging of the spine. Semin Musculoskelet Radiol. 13(2):87-96, 2009
                                                                      7. Castillo M: Diffusion-weighted imaging of the spine: is it reliable? AJNR Am J Neuroradiol. 24(6):1251-3, 2003
                                                                      8. Montazel JL et al: Normal spinal bone marrow in adults: dynamic gadolinium-enhanced MR imaging. Radiology. 229(3):703-9, 2003
                                                                      9. Otake S et al: Radiation-induced changes in MR signal intensity and contrast enhancement of lumbosacral vertebrae: do changes occur only inside the radiation therapy field? Radiology. 222(1):179-83, 2002
                                                                      10. Baur A et al: Diffusion-weighted magnetic resonance imaging of spinal bone marrow. Semin Musculoskelet Radiol. 5(1):35-42, 2001
                                                                      11. Kim HJ et al: Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging. Clin Imaging. 23(2):125-33, 1999