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KEY FACTS
Imaging
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Myelin maturation, white matter (WM) development
Definitions
- Process of myelin sheath development around axons throughout CNS
- Begins in 5th fetal month & continues throughout life
- Process of myelin sheath development around axons throughout CNS
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Bhatia V et al: MRI in normal myelination: a pictorial review. Curr Pediatr Rev. ePub, 2021
- Barkovich MJ et al: MR imaging of normal brain development. Neuroimaging Clin N Am. 29(3):325-37, 2019
- Uda S et al: Normal development of human brain white matter from infancy to early adulthood: a diffusion tensor imaging study. Dev Neurosci. 37(2):182-94, 2015
- Branson HM: Normal myelination: a practical pictorial review. Neuroimaging Clin N Am. 23(2):183-95, 2013
- Singhi S et al: Diffusion tensor imaging of the maturing paediatric cervical spinal cord: from the neonate to the young adult. J Neuroradiol. 39(3):142-8, 2012
- Welker KM et al: Assessment of normal myelination with magnetic resonance imaging. Semin Neurol. 32(1):15-28, 2012
- Zanin E et al: White matter maturation of normal human fetal brain. An in vivo diffusion tensor tractography study. Brain Behav. 1(2):95-108, 2011
- Girard N et al: Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy. Magn Reson Med. 56(4):768-75, 2006
- Jellison BJ et al: Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol. 25(3):356-69, 2004
- McGraw P et al: Evaluation of normal age-related changes in anisotropy during infancy and childhood as shown by diffusion tensor imaging. AJR Am J Roentgenol. 179(6):1515-22, 2002
- Mukherjee P et al: Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol. 23(9):1445-56, 2002
- Barkovich AJ: Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol. 21(6):1099-109, 2000
- Murakami JW et al: Normal myelination of the pediatric brain imaged with fluid-attenuated inversion-recovery (FLAIR) MR imaging. AJNR Am J Neuroradiol. 20(8):1406-11, 1999
- Nakagawa H et al: Normal myelination of anatomic nerve fiber bundles: MR analysis. AJNR Am J Neuroradiol. 19(6):1129-36, 1998
- Van der Knaap MS et al: Myelin & white matter. In Barkhof F. et al: Magnetic resonance of myelin, myelination, & myelin disorders. 2nd ed. Berlin: Springer, 1995
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References
Tables
Tables
KEY FACTS
Imaging
Diagnostic Checklist
TERMINOLOGY
Synonyms
- Myelin maturation, white matter (WM) development
Definitions
- Process of myelin sheath development around axons throughout CNS
- Begins in 5th fetal month & continues throughout life
- Process of myelin sheath development around axons throughout CNS
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Bhatia V et al: MRI in normal myelination: a pictorial review. Curr Pediatr Rev. ePub, 2021
- Barkovich MJ et al: MR imaging of normal brain development. Neuroimaging Clin N Am. 29(3):325-37, 2019
- Uda S et al: Normal development of human brain white matter from infancy to early adulthood: a diffusion tensor imaging study. Dev Neurosci. 37(2):182-94, 2015
- Branson HM: Normal myelination: a practical pictorial review. Neuroimaging Clin N Am. 23(2):183-95, 2013
- Singhi S et al: Diffusion tensor imaging of the maturing paediatric cervical spinal cord: from the neonate to the young adult. J Neuroradiol. 39(3):142-8, 2012
- Welker KM et al: Assessment of normal myelination with magnetic resonance imaging. Semin Neurol. 32(1):15-28, 2012
- Zanin E et al: White matter maturation of normal human fetal brain. An in vivo diffusion tensor tractography study. Brain Behav. 1(2):95-108, 2011
- Girard N et al: Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy. Magn Reson Med. 56(4):768-75, 2006
- Jellison BJ et al: Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol. 25(3):356-69, 2004
- McGraw P et al: Evaluation of normal age-related changes in anisotropy during infancy and childhood as shown by diffusion tensor imaging. AJR Am J Roentgenol. 179(6):1515-22, 2002
- Mukherjee P et al: Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol. 23(9):1445-56, 2002
- Barkovich AJ: Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol. 21(6):1099-109, 2000
- Murakami JW et al: Normal myelination of the pediatric brain imaged with fluid-attenuated inversion-recovery (FLAIR) MR imaging. AJNR Am J Neuroradiol. 20(8):1406-11, 1999
- Nakagawa H et al: Normal myelination of anatomic nerve fiber bundles: MR analysis. AJNR Am J Neuroradiol. 19(6):1129-36, 1998
- Van der Knaap MS et al: Myelin & white matter. In Barkhof F. et al: Magnetic resonance of myelin, myelination, & myelin disorders. 2nd ed. Berlin: Springer, 1995
