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Normal-Pressure Hydrocephalus
Valerie E. Stine, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Normal-pressure hydrocephalus (NPH): Ventriculomegaly out of proportion to sulcal enlargement in setting of normal CSF pressure

          IMAGING

          • Nuclear Medicine Findings

            • Other Modality Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              • Image Interpretation Pearls

                                Selected References

                                1. Jang H et al: Prognostic value of amyloid PET scan in normal pressure hydrocephalus. J Neurol. 265(1):63-73, 2018
                                2. Townley RA et al: 18F-FDG PET-CT pattern in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 18:897-902, 2018
                                3. Ghosh S et al: Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen. 29(7):583-9, 2014
                                4. Thut DP et al: ¹¹¹In-DTPA cisternography with SPECT/CT for the evaluation of normal pressure hydrocephalus. J Nucl Med Technol. 42(1):70-4, 2014
                                5. Virhammar J et al: Preoperative prognostic value of MRI findings in 108 patients with idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 35(12):2311-8, 2014
                                6. Ziessman HA et al: Nuclear Medicine: The Requisites. 4th edition. Saunders; 2014
                                7. Qvarlander S et al: Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 84(7):735-41, 2013
                                8. Williams MA et al: Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 3(5):375-85, 2013
                                9. Mettler FA et al: Essentials of Nuclear Medicine Imaging. 6th edition. Saunders; 2012
                                10. Marmarou A et al: Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. J Neurosurg. 102(6):987-97, 2005
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Clinical Issues

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Definitions

                                          • Normal-pressure hydrocephalus (NPH): Ventriculomegaly out of proportion to sulcal enlargement in setting of normal CSF pressure

                                        IMAGING

                                        • Nuclear Medicine Findings

                                          • Other Modality Findings

                                            • Imaging Recommendations

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • General Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Demographics

                                                      • Natural History & Prognosis

                                                        • Treatment

                                                          DIAGNOSTIC CHECKLIST

                                                          • Consider

                                                            • Image Interpretation Pearls

                                                              Selected References

                                                              1. Jang H et al: Prognostic value of amyloid PET scan in normal pressure hydrocephalus. J Neurol. 265(1):63-73, 2018
                                                              2. Townley RA et al: 18F-FDG PET-CT pattern in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 18:897-902, 2018
                                                              3. Ghosh S et al: Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen. 29(7):583-9, 2014
                                                              4. Thut DP et al: ¹¹¹In-DTPA cisternography with SPECT/CT for the evaluation of normal pressure hydrocephalus. J Nucl Med Technol. 42(1):70-4, 2014
                                                              5. Virhammar J et al: Preoperative prognostic value of MRI findings in 108 patients with idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 35(12):2311-8, 2014
                                                              6. Ziessman HA et al: Nuclear Medicine: The Requisites. 4th edition. Saunders; 2014
                                                              7. Qvarlander S et al: Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 84(7):735-41, 2013
                                                              8. Williams MA et al: Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 3(5):375-85, 2013
                                                              9. Mettler FA et al: Essentials of Nuclear Medicine Imaging. 6th edition. Saunders; 2012
                                                              10. Marmarou A et al: Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. J Neurosurg. 102(6):987-97, 2005