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Obstructive Renal Dysplasia
Roya Sohaey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Obstructive renal dysplasia (ORD)
            • Synonyms

              • Congenital obstructive uropathy
              • Obstructive nephropathy
              • Cystic renal dysplasia
              • Potter type IV
            • Definitions

              • GU obstruction → renal parenchymal dysplasia

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • Imaging Recommendations

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Matsell DG et al: Predicting outcomes and improving care in children with congenital kidney anomalies. Pediatr Nephrol. 35(10):1811-4, 2020
                                        2. Cheung KW et al: Congenital urinary tract obstruction. Best Pract Res Clin Obstet Gynaecol. 58:78-92, 2019
                                        3. Yulia A et al: Management of antenatally detected kidney malformations. Early Hum Dev. 126:38-46, 2018
                                        4. Spaggiari E et al: Sequential fetal serum β2-microglobulin to predict postnatal renal function in bilateral or low urinary tract obstruction. Ultrasound Obstet Gynecol. 49(5):617-22, 2017
                                        5. Nassr AA et al: Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction? Prenat Diagn. 36(13):1206-10, 2016
                                        6. Chow JS et al: Multidisciplinary consensus on the classification of antenatal and postnatal urinary tract dilation (UTD classification system). Pediatr Radiol. 45(6):787-9, 2015
                                        7. de Grauw AM et al: The diagnostic value of routine antenatal ultrasound in screening for congenital uropathies. J Matern Fetal Neonatal Med. 1-5, 2015
                                        8. Smith-Harrison LI et al: Current applications of in utero intervention for lower urinary tract obstruction. J Pediatr Urol. 11(6):341-7, 2015
                                        9. Vemulakonda VM et al: Inter-rater reliability of postnatal ultrasound interpretation in infants with congenital hydronephrosis. Int Urol Nephrol. 47(9):1457-61, 2015
                                        10. Thomas DF: Prenatally diagnosed urinary tract abnormalities: long-term outcome. Semin Fetal Neonatal Med. 13(3):189-95, 2008
                                        11. Robyr R et al: Correlation between ultrasound and anatomical findings in fetuses with lower urinary tract obstruction in the first half of pregnancy. Ultrasound Obstet Gynecol. 25(5):478-82, 2005
                                        12. Shibata S et al: Pathogenesis of human renal dysplasia: an alternative scenario to the major theories. Pediatr Int. 45(5):605-9, 2003
                                        13. Mercado-Deane MG et al: US of renal insufficiency in neonates. Radiographics. 22(6):1429-38, 2002
                                        14. Nagata M et al: Pathogenesis of dysplastic kidney associated with urinary tract obstruction in utero. Nephrol Dial Transplant. 17 Suppl 9:37-8, 2002
                                        15. Friedmann W et al: Perinatal differential diagnosis of cystic kidney disease and urinary tract obstruction: anatomic pathologic, ultrasonographic and genetic findings. Eur J Obstet Gynecol Reprod Biol. 89(2):127-33, 2000
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Obstructive renal dysplasia (ORD)
                                                  • Synonyms

                                                    • Congenital obstructive uropathy
                                                    • Obstructive nephropathy
                                                    • Cystic renal dysplasia
                                                    • Potter type IV
                                                  • Definitions

                                                    • GU obstruction → renal parenchymal dysplasia

                                                  IMAGING

                                                  • General Features

                                                    • Ultrasonographic Findings

                                                      • Imaging Recommendations

                                                        • MR Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Matsell DG et al: Predicting outcomes and improving care in children with congenital kidney anomalies. Pediatr Nephrol. 35(10):1811-4, 2020
                                                                              2. Cheung KW et al: Congenital urinary tract obstruction. Best Pract Res Clin Obstet Gynaecol. 58:78-92, 2019
                                                                              3. Yulia A et al: Management of antenatally detected kidney malformations. Early Hum Dev. 126:38-46, 2018
                                                                              4. Spaggiari E et al: Sequential fetal serum β2-microglobulin to predict postnatal renal function in bilateral or low urinary tract obstruction. Ultrasound Obstet Gynecol. 49(5):617-22, 2017
                                                                              5. Nassr AA et al: Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction? Prenat Diagn. 36(13):1206-10, 2016
                                                                              6. Chow JS et al: Multidisciplinary consensus on the classification of antenatal and postnatal urinary tract dilation (UTD classification system). Pediatr Radiol. 45(6):787-9, 2015
                                                                              7. de Grauw AM et al: The diagnostic value of routine antenatal ultrasound in screening for congenital uropathies. J Matern Fetal Neonatal Med. 1-5, 2015
                                                                              8. Smith-Harrison LI et al: Current applications of in utero intervention for lower urinary tract obstruction. J Pediatr Urol. 11(6):341-7, 2015
                                                                              9. Vemulakonda VM et al: Inter-rater reliability of postnatal ultrasound interpretation in infants with congenital hydronephrosis. Int Urol Nephrol. 47(9):1457-61, 2015
                                                                              10. Thomas DF: Prenatally diagnosed urinary tract abnormalities: long-term outcome. Semin Fetal Neonatal Med. 13(3):189-95, 2008
                                                                              11. Robyr R et al: Correlation between ultrasound and anatomical findings in fetuses with lower urinary tract obstruction in the first half of pregnancy. Ultrasound Obstet Gynecol. 25(5):478-82, 2005
                                                                              12. Shibata S et al: Pathogenesis of human renal dysplasia: an alternative scenario to the major theories. Pediatr Int. 45(5):605-9, 2003
                                                                              13. Mercado-Deane MG et al: US of renal insufficiency in neonates. Radiographics. 22(6):1429-38, 2002
                                                                              14. Nagata M et al: Pathogenesis of dysplastic kidney associated with urinary tract obstruction in utero. Nephrol Dial Transplant. 17 Suppl 9:37-8, 2002
                                                                              15. Friedmann W et al: Perinatal differential diagnosis of cystic kidney disease and urinary tract obstruction: anatomic pathologic, ultrasonographic and genetic findings. Eur J Obstet Gynecol Reprod Biol. 89(2):127-33, 2000