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Ochronosis
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Top Differential Diagnoses

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Alkaptonuria
        • Definitions

          • Pathologic pigmentation of connective tissues in patients with alkaptonuria
            • Enzymatic defect: Deficiency of homogentisic acid oxidase

        IMAGING

        • General Features

          • Radiographic Findings

            • MR Findings

              PATHOLOGY

              • General Features

                • Gross Pathologic & Surgical Features

                  CLINICAL ISSUES

                  • Presentation

                    • Demographics

                      • Natural History & Prognosis

                        • Treatment

                          Selected References

                          1. Lal M et al: Alkaptonuric ochronosis. Orthopedics. 37(12):e1141-9, 2014
                          2. Ventura-Ríos L et al: Ochronotic arthropathy as a paradigm of metabolically induced degenerative joint disease. A case-based review. Clin Rheumatol. ePub, 2014
                          3. Baeva M et al: AIRP best cases in radiologic-pathologic correlation: ochronosis. Radiographics. 31(4):1163-7, 2011
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          KEY FACTS

                          • Terminology

                            • Top Differential Diagnoses

                              • Clinical Issues

                                TERMINOLOGY

                                • Synonyms

                                  • Alkaptonuria
                                • Definitions

                                  • Pathologic pigmentation of connective tissues in patients with alkaptonuria
                                    • Enzymatic defect: Deficiency of homogentisic acid oxidase

                                IMAGING

                                • General Features

                                  • Radiographic Findings

                                    • MR Findings

                                      PATHOLOGY

                                      • General Features

                                        • Gross Pathologic & Surgical Features

                                          CLINICAL ISSUES

                                          • Presentation

                                            • Demographics

                                              • Natural History & Prognosis

                                                • Treatment

                                                  Selected References

                                                  1. Lal M et al: Alkaptonuric ochronosis. Orthopedics. 37(12):e1141-9, 2014
                                                  2. Ventura-Ríos L et al: Ochronotic arthropathy as a paradigm of metabolically induced degenerative joint disease. A case-based review. Clin Rheumatol. ePub, 2014
                                                  3. Baeva M et al: AIRP best cases in radiologic-pathologic correlation: ochronosis. Radiographics. 31(4):1163-7, 2011