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Musculoskeletal
Diagnosis
Non-Trauma
Arthritis
Due to Biochemical Disorders or Depositional Disease
Ochronosis
Ochronosis
Derik L. Davis, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Alkaptonuria

            • Definitions

              • Pathologic pigmentation of connective tissues in patients with alkaptonuria
                • Enzymatic deficiency of homogentisic acid oxidase

            IMAGING

            • General Features

              • Radiographic Findings

                • MR Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Boleto G et al: Ochronosis of the spine mimicking ankylosing spondylitis successfully treated with anakinra. Joint Bone Spine. 87(4):368-9, 2020
                                2. Ethiraj D et al: Alkaptonuria-an atypical case: multi-modality imaging review. Skeletal Radiol. 48(5):819-22, 2019
                                3. Lal M et al: Alkaptonuric ochronosis. Orthopedics. 37(12):e1141-9, 2014
                                4. Ventura-Ríos L et al: Ochronotic arthropathy as a paradigm of metabolically induced degenerative joint disease. A case-based review. Clin Rheumatol. 35(5):1389-95, 2014
                                5. Baeva M et al: AIRP best cases in radiologic-pathologic correlation: ochronosis. Radiographics. 31(4):1163-7, 2011
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Pathology

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Synonyms

                                            • Alkaptonuria

                                          • Definitions

                                            • Pathologic pigmentation of connective tissues in patients with alkaptonuria
                                              • Enzymatic deficiency of homogentisic acid oxidase

                                          IMAGING

                                          • General Features

                                            • Radiographic Findings

                                              • MR Findings

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    • Gross Pathologic & Surgical Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Boleto G et al: Ochronosis of the spine mimicking ankylosing spondylitis successfully treated with anakinra. Joint Bone Spine. 87(4):368-9, 2020
                                                              2. Ethiraj D et al: Alkaptonuria-an atypical case: multi-modality imaging review. Skeletal Radiol. 48(5):819-22, 2019
                                                              3. Lal M et al: Alkaptonuric ochronosis. Orthopedics. 37(12):e1141-9, 2014
                                                              4. Ventura-Ríos L et al: Ochronotic arthropathy as a paradigm of metabolically induced degenerative joint disease. A case-based review. Clin Rheumatol. 35(5):1389-95, 2014
                                                              5. Baeva M et al: AIRP best cases in radiologic-pathologic correlation: ochronosis. Radiographics. 31(4):1163-7, 2011