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Oligodendroglioma
Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Well-differentiated, slowly growing, but diffusely infiltrating, cortical/subcortical tumor

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Ogura R et al: Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas. Neuropathology. ePub, 2015
                                            2. Reuss DE et al: ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. Acta Neuropathol. 129(1):133-46, 2015
                                            3. Sahm F et al: Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropathol. 128(4):551-9, 2014
                                            4. Chawla S et al: Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy. AJNR Am J Neuroradiol. 34(8):1542-9, 2013
                                            5. Jia Z et al: Low-grade and anaplastic oligodendrogliomas: differences in tumour microvascular permeability evaluated with dynamic contrast-enhanced magnetic resonance imaging. J Clin Neurosci. 20(8):1110-3, 2013
                                            6. Kesari S et al: Phase II study of protracted daily temozolomide for low-grade gliomas in adults. Clin Cancer Res. 15(1):330-7, 2009
                                            7. Sepulveda Sanchez JM et al: Classification of oligodendroglial tumors based on histopathology criteria is a significant predictor of survival--clinical, radiological and pathologic long-term follow-up analysis. Clin Neuropathol. 28(1):11-20, 2009
                                            8. Bondy ML et al: Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 113(7 Suppl):1953-68, 2008
                                            9. Cairncross G et al: Gliomas with 1p/19q codeletion: a.k.a. oligodendroglioma. Cancer J. 14(6):352-7, 2008
                                            10. Flannery T et al: Familial occurrence of oligodendroglial tumours. Br J Neurosurg. 22(3):436-8, 2008
                                            11. Louis DN et al: WHO Classification of Tumours of the Central Nervous System: Oligodendroglioma. Lyon: IARC Press. 54-59, 2007
                                            12. Spampinato MV et al: Cerebral blood volume measurements and proton MR spectroscopy in grading of oligodendroglial tumors. AJR Am J Roentgenol. 188(1):204-12, 2007
                                            13. Maia AC Jr et al: MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomas. AJNR Am J Neuroradiol. 26(4):777-83, 2005
                                            14. Xu M et al: Comparison of magnetic resonance spectroscopy and perfusion-weighted imaging in presurgical grading of oligodendroglial tumors. Neurosurgery. 56(5):919-26; discussion 919-26, 2005
                                            15. Azzarelli B et al: Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. J Neuropathol Exp Neurol. 63(2):170-9, 2004
                                            16. Lev MH et al: Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol. 25(2):214-21, 2004
                                            17. Perry JR: Oligodendrogliomas: clinical and genetic correlations. Curr Opin Neurol. 14(6): 705-10, 2001
                                            18. Derlon JM et al: Non-invasive grading of oligodendrogliomas: correlation between in vivo metabolic pattern and histopathology. Eur J Nucl Med. 27(7):778-87, 2000
                                            19. Prayson RA et al: Clinicopathologic study of forty-four histologically pure supratentorial oligodendrogliomas. Ann Diagn Pathol. 4(4):218-27, 2000
                                            20. Caseiras GB et al: Relative cerebral blood volume measurements of low-grade gliomas predict patient outcome in a multi-institution setting. Eur J Radiol.
                                            21. Schomas DA et al: Intracranial Low-Grade Gliomas in Adults: 30-Year Experience With Long-term Follow-up at Mayo Clinic. Neuro Oncol.
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Well-differentiated, slowly growing, but diffusely infiltrating, cortical/subcortical tumor

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Ogura R et al: Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas. Neuropathology. ePub, 2015
                                                                                      2. Reuss DE et al: ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. Acta Neuropathol. 129(1):133-46, 2015
                                                                                      3. Sahm F et al: Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropathol. 128(4):551-9, 2014
                                                                                      4. Chawla S et al: Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy. AJNR Am J Neuroradiol. 34(8):1542-9, 2013
                                                                                      5. Jia Z et al: Low-grade and anaplastic oligodendrogliomas: differences in tumour microvascular permeability evaluated with dynamic contrast-enhanced magnetic resonance imaging. J Clin Neurosci. 20(8):1110-3, 2013
                                                                                      6. Kesari S et al: Phase II study of protracted daily temozolomide for low-grade gliomas in adults. Clin Cancer Res. 15(1):330-7, 2009
                                                                                      7. Sepulveda Sanchez JM et al: Classification of oligodendroglial tumors based on histopathology criteria is a significant predictor of survival--clinical, radiological and pathologic long-term follow-up analysis. Clin Neuropathol. 28(1):11-20, 2009
                                                                                      8. Bondy ML et al: Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 113(7 Suppl):1953-68, 2008
                                                                                      9. Cairncross G et al: Gliomas with 1p/19q codeletion: a.k.a. oligodendroglioma. Cancer J. 14(6):352-7, 2008
                                                                                      10. Flannery T et al: Familial occurrence of oligodendroglial tumours. Br J Neurosurg. 22(3):436-8, 2008
                                                                                      11. Louis DN et al: WHO Classification of Tumours of the Central Nervous System: Oligodendroglioma. Lyon: IARC Press. 54-59, 2007
                                                                                      12. Spampinato MV et al: Cerebral blood volume measurements and proton MR spectroscopy in grading of oligodendroglial tumors. AJR Am J Roentgenol. 188(1):204-12, 2007
                                                                                      13. Maia AC Jr et al: MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomas. AJNR Am J Neuroradiol. 26(4):777-83, 2005
                                                                                      14. Xu M et al: Comparison of magnetic resonance spectroscopy and perfusion-weighted imaging in presurgical grading of oligodendroglial tumors. Neurosurgery. 56(5):919-26; discussion 919-26, 2005
                                                                                      15. Azzarelli B et al: Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. J Neuropathol Exp Neurol. 63(2):170-9, 2004
                                                                                      16. Lev MH et al: Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol. 25(2):214-21, 2004
                                                                                      17. Perry JR: Oligodendrogliomas: clinical and genetic correlations. Curr Opin Neurol. 14(6): 705-10, 2001
                                                                                      18. Derlon JM et al: Non-invasive grading of oligodendrogliomas: correlation between in vivo metabolic pattern and histopathology. Eur J Nucl Med. 27(7):778-87, 2000
                                                                                      19. Prayson RA et al: Clinicopathologic study of forty-four histologically pure supratentorial oligodendrogliomas. Ann Diagn Pathol. 4(4):218-27, 2000
                                                                                      20. Caseiras GB et al: Relative cerebral blood volume measurements of low-grade gliomas predict patient outcome in a multi-institution setting. Eur J Radiol.
                                                                                      21. Schomas DA et al: Intracranial Low-Grade Gliomas in Adults: 30-Year Experience With Long-term Follow-up at Mayo Clinic. Neuro Oncol.