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Ollier Disease
Cheryl A. Petersilge, MD, MBA; Nancy A. Chauvin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Enchondromatosis
            • Dyschondroplasia
          • Definitions

            • Ollier disease: dysplasia involving predominantly metaphyses, containing chondroid matrix
              • Dysplasia, not simply multiple enchondromas
                • 3 or more asymmetrically distributed enchondromas (usually within 1 side of body)
              • Most common of enchondromatosis subtypes

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Sharif B et al: Update on the imaging features of the enchondromatosis syndromes. Skeletal Radiol. ePub, 2021
                                      2. Herget GW et al: Insights into enchondroma, enchondromatosis and the risk of secondary chondrosarcoma. Review of the literature with an emphasis on the clinical behaviour, radiology, malignant transformation and the follow up. Neoplasma. 61(4):365-78, 2014
                                      3. Le BB et al: Ollier disease with digital enchondromatosis: anatomic and functional imaging. Clin Nucl Med. 39(8):e375-8, 2014
                                      4. Verdegaal SH et al: Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist. 16(12):1771-9, 2011
                                      5. Pansuriya TC et al: Enchondromatosis: insights on the different subtypes. Int J Clin Exp Pathol. 3(6):557-69, 2010
                                      6. Silve C et al: Ollier disease. Orphanet J Rare Dis. 1:37, 2006
                                      7. Unni KK: Cartilaginous lesions of bone. J Orthop Sci. 6(5):457-72, 2001
                                      8. Shapiro F: Ollier's Disease. An assessment of angular deformity, shortening, and pathological fracture in twenty-one patients. J Bone Joint Surg Am. 64(1):95-103, 1982
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Enchondromatosis
                                                • Dyschondroplasia
                                              • Definitions

                                                • Ollier disease: dysplasia involving predominantly metaphyses, containing chondroid matrix
                                                  • Dysplasia, not simply multiple enchondromas
                                                    • 3 or more asymmetrically distributed enchondromas (usually within 1 side of body)
                                                  • Most common of enchondromatosis subtypes

                                              IMAGING

                                              • General Features

                                                • Imaging Recommendations

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Nuclear Medicine Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Sharif B et al: Update on the imaging features of the enchondromatosis syndromes. Skeletal Radiol. ePub, 2021
                                                                          2. Herget GW et al: Insights into enchondroma, enchondromatosis and the risk of secondary chondrosarcoma. Review of the literature with an emphasis on the clinical behaviour, radiology, malignant transformation and the follow up. Neoplasma. 61(4):365-78, 2014
                                                                          3. Le BB et al: Ollier disease with digital enchondromatosis: anatomic and functional imaging. Clin Nucl Med. 39(8):e375-8, 2014
                                                                          4. Verdegaal SH et al: Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist. 16(12):1771-9, 2011
                                                                          5. Pansuriya TC et al: Enchondromatosis: insights on the different subtypes. Int J Clin Exp Pathol. 3(6):557-69, 2010
                                                                          6. Silve C et al: Ollier disease. Orphanet J Rare Dis. 1:37, 2006
                                                                          7. Unni KK: Cartilaginous lesions of bone. J Orthop Sci. 6(5):457-72, 2001
                                                                          8. Shapiro F: Ollier's Disease. An assessment of angular deformity, shortening, and pathological fracture in twenty-one patients. J Bone Joint Surg Am. 64(1):95-103, 1982