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Head and Neck
Diagnosis
Orbit
Infectious and Inflammatory Lesions
Optic Neuritis
Optic Neuritis
H. Christian Davidson, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Optic neuritis (ON)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Other Modalities

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              • Reporting Tips

                                                Selected References

                                                1. Marques IB et al: Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI. J Clin Neurosci. 21(4):583-6, 2014
                                                2. Toosy AT et al: Optic neuritis. Lancet Neurol. 13(1):83-99, 2014
                                                3. He M et al: The use of diffusion MRI in ischemic optic neuropathy and optic neuritis. Semin Ophthalmol. 25(5-6):225-32, 2010
                                                4. Swanton JK et al: Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis. Mult Scler. 16(2):156-65, 2010
                                                5. Alper G et al: Demyelinating optic neuritis in children. J Child Neurol. 24(1):45-8, 2009
                                                6. Bonhomme GR et al: Pediatric optic neuritis: brain MRI abnormalities and risk of multiple sclerosis. Neurology. 72(10):881-5, 2009
                                                7. Osborne BJ et al: Optic neuritis and risk of MS: differential diagnosis and management. Cleve Clin J Med. 76(3):181-90, 2009
                                                8. Swanton JK et al: Early MRI in optic neuritis: the risk for disability. Neurology. 72(6):542-50, 2009
                                                9. Matiello M et al: NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology. 70(23):2197-200, 2008
                                                10. Optic Neuritis Study Group: Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol. 65(6):727-32, 2008
                                                11. Volpe NJ: The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results. Arch Ophthalmol. 126(7):996-9, 2008
                                                12. Al-Shafai LS et al: Diffusion MR imaging in a case of acute ischemic optic neuropathy. AJNR Am J Neuroradiol. 27(2):255-7, 2006
                                                13. Wilejto M et al: The clinical features, MRI findings, and outcome of optic neuritis in children. Neurology. 67(2):258-62, 2006
                                                14. Wingerchuk DM et al: Revised diagnostic criteria for neuromyelitis optica. Neurology. 66(10):1485-9, 2006
                                                15. Hickman SJ et al: Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis. AJNR Am J Neuroradiol. 26(4):951-6, 2005
                                                16. Beck RW et al: Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial. Am J Ophthalmol. 137(1):77-83, 2004
                                                17. Hickman SJ et al: Management of acute optic neuritis. Lancet. 360(9349):1953-62, 2002
                                                18. Rizzo JF 3rd et al: Use of magnetic resonance imaging to differentiate optic neuritis and nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 109(9):1679-84, 2002
                                                19. Kaufman DI et al: Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 54(11):2039-44, 2000
                                                20. Sorensen TL et al: Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long-term survey. Neurology. 53(3):473-8, 1999
                                                21. Hudgins PA et al: Radiation-induced optic neuropathy: characteristic appearances on gadolinium-enhanced MR. AJNR Am J Neuroradiol. 13(1):235-8, 1992
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Optic neuritis (ON)

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Other Modalities

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          • Image Interpretation Pearls

                                                                                            • Reporting Tips

                                                                                              Selected References

                                                                                              1. Marques IB et al: Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI. J Clin Neurosci. 21(4):583-6, 2014
                                                                                              2. Toosy AT et al: Optic neuritis. Lancet Neurol. 13(1):83-99, 2014
                                                                                              3. He M et al: The use of diffusion MRI in ischemic optic neuropathy and optic neuritis. Semin Ophthalmol. 25(5-6):225-32, 2010
                                                                                              4. Swanton JK et al: Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis. Mult Scler. 16(2):156-65, 2010
                                                                                              5. Alper G et al: Demyelinating optic neuritis in children. J Child Neurol. 24(1):45-8, 2009
                                                                                              6. Bonhomme GR et al: Pediatric optic neuritis: brain MRI abnormalities and risk of multiple sclerosis. Neurology. 72(10):881-5, 2009
                                                                                              7. Osborne BJ et al: Optic neuritis and risk of MS: differential diagnosis and management. Cleve Clin J Med. 76(3):181-90, 2009
                                                                                              8. Swanton JK et al: Early MRI in optic neuritis: the risk for disability. Neurology. 72(6):542-50, 2009
                                                                                              9. Matiello M et al: NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology. 70(23):2197-200, 2008
                                                                                              10. Optic Neuritis Study Group: Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol. 65(6):727-32, 2008
                                                                                              11. Volpe NJ: The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results. Arch Ophthalmol. 126(7):996-9, 2008
                                                                                              12. Al-Shafai LS et al: Diffusion MR imaging in a case of acute ischemic optic neuropathy. AJNR Am J Neuroradiol. 27(2):255-7, 2006
                                                                                              13. Wilejto M et al: The clinical features, MRI findings, and outcome of optic neuritis in children. Neurology. 67(2):258-62, 2006
                                                                                              14. Wingerchuk DM et al: Revised diagnostic criteria for neuromyelitis optica. Neurology. 66(10):1485-9, 2006
                                                                                              15. Hickman SJ et al: Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis. AJNR Am J Neuroradiol. 26(4):951-6, 2005
                                                                                              16. Beck RW et al: Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial. Am J Ophthalmol. 137(1):77-83, 2004
                                                                                              17. Hickman SJ et al: Management of acute optic neuritis. Lancet. 360(9349):1953-62, 2002
                                                                                              18. Rizzo JF 3rd et al: Use of magnetic resonance imaging to differentiate optic neuritis and nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 109(9):1679-84, 2002
                                                                                              19. Kaufman DI et al: Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 54(11):2039-44, 2000
                                                                                              20. Sorensen TL et al: Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long-term survey. Neurology. 53(3):473-8, 1999
                                                                                              21. Hudgins PA et al: Radiation-induced optic neuropathy: characteristic appearances on gadolinium-enhanced MR. AJNR Am J Neuroradiol. 13(1):235-8, 1992
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