Oral cavity minor salivary gland malignancy (MSGM)
Definitions
Primary minor salivary gland malignancy
Located in submucosa upper aerodigestive tract
Most common MSGM: Adenoid cystic carcinoma (ACCa) and mucoepidermoid carcinoma (MECa)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Sarma M et al: Pleomorphic adenoma of tongue: a case report. Indian J Otolaryngol Head Neck Surg. 72(1):145-7, 2020
Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
Buch SA et al: A rare case of long-standing mucoepidermoid carcinoma of minor salivary glands of the palate. Stomatologija. 21(3):92-6, 2019
Hay AJ et al: Minor salivary gland tumors of the head and neck-Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type. Cancer. ePub, 2019
Hämetoja H et al: Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways. Virchows Arch. 475(5):609-16, 2019
Khanna D et al: Carcinoma ex pleomorphic adenoma: a case report and review of literature. Afr Health Sci. 19(4):3253-63, 2019
Mimica X et al: Polymorphous adenocarcinoma of salivary glands. Oral Oncol. 95:52-8, 2019
Munhoz L et al: Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(3):280-310, 2019
Nawroz I et al: Minor salivary gland intraductal mucoepidermoid carcinoma: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(1):e13-e15, 2019
Nonitha S et al: Histomorphological comparison of pleomorphic adenoma in major and minor salivary glands of oral cavity: A comparative study. J Oral Maxillofac Pathol. 23(3):356-62, 2019
Abdel Razek AAK et al: Imaging of minor salivary glands. Neuroimaging Clin N Am. 28(2):295-302, 2018
Feng AL et al: Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review. Laryngoscope. 128(12):2759-61, 2018
Gill S et al: Mucoepidermoid carcinoma of hard palate. Indian J Pathol Microbiol. 61(3):397-8, 2018
Mokhniuk K et al: Cytological investigation of a first case of basal cell adenocarcinoma arising in the minor salivary glands. Case report and review of the literature. Diagn Cytopathol. 46(8):682-4, 2018
Roy S et al: Mammary analogue secretory carcinoma of minor salivary glands: A rare case series and review of the literature. Ann Clin Lab Sci. 48(1):94-9, 2018
von Stempel C et al: Imaging of palatal lumps. Clin Radiol. 72(2):97-107, 2017
Aydil U et al: Neoplasms of the hard palate. J Oral Maxillofac Surg. 72(3):619-26, 2014
Kato H et al: CT and MR imaging findings of palatal tumors. Eur J Radiol. 83(3):e137-46, 2014
Kimple AJ et al: Polymorphous low-grade adenocarcinoma: a case series and determination of recurrence. Laryngoscope. 124(12):2714-9, 2014
Chuiwa H et al: Minor salivary gland carcinomas of oral cavity and oropharynx. J Laryngol Otol Suppl. (31):52-7, 2009
Dhanuthai K et al: A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med. 38(6):495-500, 2009
Mücke T et al: Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108(1):81-9, 2009
Agarwal JP et al: Intraoral adenoid cystic carcinoma: prognostic factors and outcome. Oral Oncol. 44(10):986-93, 2008
Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
Buchner A et al: Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med. 36(4):207-14, 2007
Pires FR et al: Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 43(5):463-70, 2007
Wang D et al: Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104(1):94-100, 2007
Yih WY et al: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 63(6):805-10, 2005
Kolude B et al: Mucoepidermoid carcinoma of the oral cavity. J Natl Med Assoc. 93(5):178-84, 2001
Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
Jones AS et al: Tumours of the minor salivary glands. Clin Otolaryngol Allied Sci. 23(1):27-33, 1998
Kurabayashi T et al: Differential diagnosis of tumours of the minor salivary glands of the palate by computed tomography. Dentomaxillofac Radiol. 26(1):16-21, 1997
Parsons JT et al: Management of minor salivary gland carcinomas. Int J Radiat Oncol Biol Phys. 35(3):443-54, 1996
Beckhardt RN et al: Minor salivary gland tumors of the palate: clinical and pathologic correlates of outcome. Laryngoscope. 105(11):1155-60, 1995
Garden AS et al: Postoperative radiation therapy for malignant tumors of minor salivary glands. Outcome and patterns of failure. Cancer. 73(10):2563-9, 1994
Sadeghi A et al: Minor salivary gland tumors of the head and neck: treatment strategies and prognosis. Am J Clin Oncol. 16(1):3-8, 1993
Spiro RH et al: The importance of clinical staging of minor salivary gland carcinoma. Am J Surg. 162(4):330-6, 1991
Weber RS et al: Minor salivary gland tumors of the lip and buccal mucosa. Laryngoscope. 99(1):6-9, 1989
Ellis ER et al: The use of radiation therapy in the management of minor salivary gland tumors. Int J Radiat Oncol Biol Phys. 15(3):613-7, 1988
Evans HL et al: Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. Cancer. 53(4):935-42, 1984
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References
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Oral cavity minor salivary gland malignancy (MSGM)
Definitions
Primary minor salivary gland malignancy
Located in submucosa upper aerodigestive tract
Most common MSGM: Adenoid cystic carcinoma (ACCa) and mucoepidermoid carcinoma (MECa)
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Sarma M et al: Pleomorphic adenoma of tongue: a case report. Indian J Otolaryngol Head Neck Surg. 72(1):145-7, 2020
Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
Buch SA et al: A rare case of long-standing mucoepidermoid carcinoma of minor salivary glands of the palate. Stomatologija. 21(3):92-6, 2019
Hay AJ et al: Minor salivary gland tumors of the head and neck-Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type. Cancer. ePub, 2019
Hämetoja H et al: Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways. Virchows Arch. 475(5):609-16, 2019
Khanna D et al: Carcinoma ex pleomorphic adenoma: a case report and review of literature. Afr Health Sci. 19(4):3253-63, 2019
Mimica X et al: Polymorphous adenocarcinoma of salivary glands. Oral Oncol. 95:52-8, 2019
Munhoz L et al: Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(3):280-310, 2019
Nawroz I et al: Minor salivary gland intraductal mucoepidermoid carcinoma: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(1):e13-e15, 2019
Nonitha S et al: Histomorphological comparison of pleomorphic adenoma in major and minor salivary glands of oral cavity: A comparative study. J Oral Maxillofac Pathol. 23(3):356-62, 2019
Abdel Razek AAK et al: Imaging of minor salivary glands. Neuroimaging Clin N Am. 28(2):295-302, 2018
Feng AL et al: Multiple simultaneous head and neck cancers in Lynch syndrome: Case report and literature review. Laryngoscope. 128(12):2759-61, 2018
Gill S et al: Mucoepidermoid carcinoma of hard palate. Indian J Pathol Microbiol. 61(3):397-8, 2018
Mokhniuk K et al: Cytological investigation of a first case of basal cell adenocarcinoma arising in the minor salivary glands. Case report and review of the literature. Diagn Cytopathol. 46(8):682-4, 2018
Roy S et al: Mammary analogue secretory carcinoma of minor salivary glands: A rare case series and review of the literature. Ann Clin Lab Sci. 48(1):94-9, 2018
von Stempel C et al: Imaging of palatal lumps. Clin Radiol. 72(2):97-107, 2017
Aydil U et al: Neoplasms of the hard palate. J Oral Maxillofac Surg. 72(3):619-26, 2014
Kato H et al: CT and MR imaging findings of palatal tumors. Eur J Radiol. 83(3):e137-46, 2014
Kimple AJ et al: Polymorphous low-grade adenocarcinoma: a case series and determination of recurrence. Laryngoscope. 124(12):2714-9, 2014
Chuiwa H et al: Minor salivary gland carcinomas of oral cavity and oropharynx. J Laryngol Otol Suppl. (31):52-7, 2009
Dhanuthai K et al: A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med. 38(6):495-500, 2009
Mücke T et al: Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108(1):81-9, 2009
Agarwal JP et al: Intraoral adenoid cystic carcinoma: prognostic factors and outcome. Oral Oncol. 44(10):986-93, 2008
Lee YY et al: Imaging of salivary gland tumours. Eur J Radiol. 66(3):419-36, 2008
Buchner A et al: Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med. 36(4):207-14, 2007
Pires FR et al: Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 43(5):463-70, 2007
Wang D et al: Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104(1):94-100, 2007
Yih WY et al: Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 63(6):805-10, 2005
Kolude B et al: Mucoepidermoid carcinoma of the oral cavity. J Natl Med Assoc. 93(5):178-84, 2001
Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
Jones AS et al: Tumours of the minor salivary glands. Clin Otolaryngol Allied Sci. 23(1):27-33, 1998
Kurabayashi T et al: Differential diagnosis of tumours of the minor salivary glands of the palate by computed tomography. Dentomaxillofac Radiol. 26(1):16-21, 1997
Parsons JT et al: Management of minor salivary gland carcinomas. Int J Radiat Oncol Biol Phys. 35(3):443-54, 1996
Beckhardt RN et al: Minor salivary gland tumors of the palate: clinical and pathologic correlates of outcome. Laryngoscope. 105(11):1155-60, 1995
Garden AS et al: Postoperative radiation therapy for malignant tumors of minor salivary glands. Outcome and patterns of failure. Cancer. 73(10):2563-9, 1994
Sadeghi A et al: Minor salivary gland tumors of the head and neck: treatment strategies and prognosis. Am J Clin Oncol. 16(1):3-8, 1993
Spiro RH et al: The importance of clinical staging of minor salivary gland carcinoma. Am J Surg. 162(4):330-6, 1991
Weber RS et al: Minor salivary gland tumors of the lip and buccal mucosa. Laryngoscope. 99(1):6-9, 1989
Ellis ER et al: The use of radiation therapy in the management of minor salivary gland tumors. Int J Radiat Oncol Biol Phys. 15(3):613-7, 1988
Evans HL et al: Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. Cancer. 53(4):935-42, 1984
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