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Orbital Infantile Hemangioma
Deborah R. Shatzkes, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Orbital capillary hemangioma, infantile periocular hemangioma
            • Definitions

              • Benign vascular tumor of infancy
              • Distinct lesion from vascular malformation

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              • Reporting Tips

                                                Selected References

                                                1. Bauman NM et al: Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 140(4):323-30, 2014
                                                2. Lee D et al: Propranolol targets contractility of infantile hemangioma-derived pericytes. Br J Dermatol. Epub ahead of print, 2014
                                                3. Luo Y et al: A retrospective study of propranolol therapy in 635 infants with infantile hemangioma. Pediatr Dermatol. Epub ahead of print, 2014
                                                4. Huoh KC et al: Infantile hemangiomas of the head and neck. Pediatr Clin North Am. 60(4):937-49, 2013
                                                5. Uihlein LC et al: Pathogenesis of infantile hemangiomas. Pediatr Ann. 41(8):1-6, 2012
                                                6. Greene AK et al: Vascular anomalies in 5,621 patients: guidelines for referral. J Pediatr Surg. 46(9):1784-9, 2011
                                                7. Nguyen J et al: Pharmacologic therapy for periocular infantile hemangiomas: a review of the literature. Semin Ophthalmol. 24(3):178-84, 2009
                                                8. Chan LK et al: The management of periorbital fat excess in haemangioma involution. J Plast Reconstr Aesthet Surg. 61(2):133-7, 2008
                                                9. Frank RC et al: Visual development in infants: visual complications of periocular haemangiomas. J Plast Reconstr Aesthet Surg. Epub ahead of print, 2008
                                                10. Tronina SA et al: Combined surgical method of orbital and periorbital hemangioma treatment in infants. Orbit. 27(4):249-57, 2008
                                                11. Weiss AH et al: Reappraisal of astigmatism induced by periocular capillary hemangioma and treatment with intralesional corticosteroid injection. Ophthalmology. 115(2):390-397, 2008
                                                12. Chung EM et al: From the archives of the AFIP: Pediatric orbit tumors and tumorlike lesions: nonosseous lesions of the extraocular orbit. Radiographics. 27(6):1777-99, 2007
                                                13. Judd CD et al: Intracranial infantile hemangiomas associated with PHACE syndrome. AJNR Am J Neuroradiol. 28(1):25-9, 2007
                                                14. Levi M et al: Surgical treatment of capillary hemangiomas causing amblyopia. J AAPOS. 11(3):230-4, 2007
                                                15. Reddy AR et al: Is this really a capillary haemangioma? Orbit. 26(4):327-9, 2007
                                                16. Dubois J et al: Orbit and eyelid hemangiomas: is there a relationship between location and ocular problems? J Am Acad Dermatol. 55(4):614-9, 2006
                                                17. Kavanagh EC et al: Imaging of the natural history of an orbital capillary hemangioma. Orbit. 25(1):69-72, 2006
                                                18. Schwartz SR et al: Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J AAPOS. 10(3):262-8, 2006
                                                19. Verity DH et al: Natural history of periocular capillary haemangiomas: changes in internal blood velocity and lesion volume. Eye. 20(10):1228-37, 2006
                                                20. Ersoy S et al: Hemifacial infantile hemangioma with intracranial extension: a rare entity. Pediatr Dermatol. 22(4):309-13, 2005
                                                21. Neudorfer M et al: Intraorbital and periorbital tumors in children--value of ultrasound and color Doppler imaging in the differential diagnosis. Am J Ophthalmol. 137(6):1065-72, 2004
                                                22. Castillo BV Jr et al: Pediatric tumors of the eye and orbit. Pediatr Clin North Am. 50(1):149-72, 2003
                                                23. O'Keefe M et al: Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. Acta Ophthalmol Scand. 81(3):294-8, 2003
                                                24. Rootman J: Vascular malformations of the orbit: hemodynamic concepts. Orbit. 22(2):103-20, 2003
                                                25. Waner M et al: The nonrandom distribution of facial hemangiomas. Arch Dermatol. 139(7):869-75, 2003
                                                26. Sleep TJ et al: Doppler ultrasonography to aid diagnosis of orbital capillary haemangioma in neonates. Eye. 16(3):316-9, 2002
                                                27. Bilaniuk LT: Orbital vascular lesions. Role of imaging. Radiol Clin North Am. 37(1):169-83, xi, 1999
                                                28. Harris GJ: Orbital vascular malformations: a consensus statement on terminology and its clinical implications. Orbital Society. Am J Ophthalmol. 127(4):453-5, 1999
                                                29. Walter JW et al: Genetic mapping of a novel familial form of infantile hemangioma. Am J Med Genet. 82(1):77-83, 1999
                                                30. Forbes G: Vascular lesions in the orbit. Neuroimaging Clin N Am. 6(1):113-22, 1996
                                                31. Rootman J et al: Multidisciplinary approaches to complicated vascular lesions of the orbit. Ophthalmology. 99(9):1440-6, 1992
                                                32. Mafee MF et al: Dynamic computed tomography and its application to ophthalmology. Radiol Clin North Am. 25(4):715-31, 1987
                                                33. Mafee MF et al: Orbital space-occupying lesions: role of computed tomography and magnetic resonance imaging. An analysis of 145 cases. Radiol Clin North Am. 25(3):529-59, 1987
                                                34. Sklar EL et al: Correlative study of the computed tomographic, ultrasonographic, and pathological characteristics of cavernous versus capillary hemangiomas of the orbit. J Clin Neuroophthalmol. 6(1):14-21, 1986
                                                35. Mulliken JB et al: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69(3):412-22, 1982
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Top Differential Diagnoses

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Synonyms

                                                            • Orbital capillary hemangioma, infantile periocular hemangioma
                                                          • Definitions

                                                            • Benign vascular tumor of infancy
                                                            • Distinct lesion from vascular malformation

                                                          IMAGING

                                                          • General Features

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Angiographic Findings

                                                                    • Imaging Recommendations

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Staging, Grading, & Classification

                                                                            • Gross Pathologic & Surgical Features

                                                                              • Microscopic Features

                                                                                CLINICAL ISSUES

                                                                                • Presentation

                                                                                  • Demographics

                                                                                    • Natural History & Prognosis

                                                                                      • Treatment

                                                                                        DIAGNOSTIC CHECKLIST

                                                                                        • Consider

                                                                                          • Image Interpretation Pearls

                                                                                            • Reporting Tips

                                                                                              Selected References

                                                                                              1. Bauman NM et al: Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 140(4):323-30, 2014
                                                                                              2. Lee D et al: Propranolol targets contractility of infantile hemangioma-derived pericytes. Br J Dermatol. Epub ahead of print, 2014
                                                                                              3. Luo Y et al: A retrospective study of propranolol therapy in 635 infants with infantile hemangioma. Pediatr Dermatol. Epub ahead of print, 2014
                                                                                              4. Huoh KC et al: Infantile hemangiomas of the head and neck. Pediatr Clin North Am. 60(4):937-49, 2013
                                                                                              5. Uihlein LC et al: Pathogenesis of infantile hemangiomas. Pediatr Ann. 41(8):1-6, 2012
                                                                                              6. Greene AK et al: Vascular anomalies in 5,621 patients: guidelines for referral. J Pediatr Surg. 46(9):1784-9, 2011
                                                                                              7. Nguyen J et al: Pharmacologic therapy for periocular infantile hemangiomas: a review of the literature. Semin Ophthalmol. 24(3):178-84, 2009
                                                                                              8. Chan LK et al: The management of periorbital fat excess in haemangioma involution. J Plast Reconstr Aesthet Surg. 61(2):133-7, 2008
                                                                                              9. Frank RC et al: Visual development in infants: visual complications of periocular haemangiomas. J Plast Reconstr Aesthet Surg. Epub ahead of print, 2008
                                                                                              10. Tronina SA et al: Combined surgical method of orbital and periorbital hemangioma treatment in infants. Orbit. 27(4):249-57, 2008
                                                                                              11. Weiss AH et al: Reappraisal of astigmatism induced by periocular capillary hemangioma and treatment with intralesional corticosteroid injection. Ophthalmology. 115(2):390-397, 2008
                                                                                              12. Chung EM et al: From the archives of the AFIP: Pediatric orbit tumors and tumorlike lesions: nonosseous lesions of the extraocular orbit. Radiographics. 27(6):1777-99, 2007
                                                                                              13. Judd CD et al: Intracranial infantile hemangiomas associated with PHACE syndrome. AJNR Am J Neuroradiol. 28(1):25-9, 2007
                                                                                              14. Levi M et al: Surgical treatment of capillary hemangiomas causing amblyopia. J AAPOS. 11(3):230-4, 2007
                                                                                              15. Reddy AR et al: Is this really a capillary haemangioma? Orbit. 26(4):327-9, 2007
                                                                                              16. Dubois J et al: Orbit and eyelid hemangiomas: is there a relationship between location and ocular problems? J Am Acad Dermatol. 55(4):614-9, 2006
                                                                                              17. Kavanagh EC et al: Imaging of the natural history of an orbital capillary hemangioma. Orbit. 25(1):69-72, 2006
                                                                                              18. Schwartz SR et al: Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J AAPOS. 10(3):262-8, 2006
                                                                                              19. Verity DH et al: Natural history of periocular capillary haemangiomas: changes in internal blood velocity and lesion volume. Eye. 20(10):1228-37, 2006
                                                                                              20. Ersoy S et al: Hemifacial infantile hemangioma with intracranial extension: a rare entity. Pediatr Dermatol. 22(4):309-13, 2005
                                                                                              21. Neudorfer M et al: Intraorbital and periorbital tumors in children--value of ultrasound and color Doppler imaging in the differential diagnosis. Am J Ophthalmol. 137(6):1065-72, 2004
                                                                                              22. Castillo BV Jr et al: Pediatric tumors of the eye and orbit. Pediatr Clin North Am. 50(1):149-72, 2003
                                                                                              23. O'Keefe M et al: Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. Acta Ophthalmol Scand. 81(3):294-8, 2003
                                                                                              24. Rootman J: Vascular malformations of the orbit: hemodynamic concepts. Orbit. 22(2):103-20, 2003
                                                                                              25. Waner M et al: The nonrandom distribution of facial hemangiomas. Arch Dermatol. 139(7):869-75, 2003
                                                                                              26. Sleep TJ et al: Doppler ultrasonography to aid diagnosis of orbital capillary haemangioma in neonates. Eye. 16(3):316-9, 2002
                                                                                              27. Bilaniuk LT: Orbital vascular lesions. Role of imaging. Radiol Clin North Am. 37(1):169-83, xi, 1999
                                                                                              28. Harris GJ: Orbital vascular malformations: a consensus statement on terminology and its clinical implications. Orbital Society. Am J Ophthalmol. 127(4):453-5, 1999
                                                                                              29. Walter JW et al: Genetic mapping of a novel familial form of infantile hemangioma. Am J Med Genet. 82(1):77-83, 1999
                                                                                              30. Forbes G: Vascular lesions in the orbit. Neuroimaging Clin N Am. 6(1):113-22, 1996
                                                                                              31. Rootman J et al: Multidisciplinary approaches to complicated vascular lesions of the orbit. Ophthalmology. 99(9):1440-6, 1992
                                                                                              32. Mafee MF et al: Dynamic computed tomography and its application to ophthalmology. Radiol Clin North Am. 25(4):715-31, 1987
                                                                                              33. Mafee MF et al: Orbital space-occupying lesions: role of computed tomography and magnetic resonance imaging. An analysis of 145 cases. Radiol Clin North Am. 25(3):529-59, 1987
                                                                                              34. Sklar EL et al: Correlative study of the computed tomographic, ultrasonographic, and pathological characteristics of cavernous versus capillary hemangiomas of the orbit. J Clin Neuroophthalmol. 6(1):14-21, 1986
                                                                                              35. Mulliken JB et al: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69(3):412-22, 1982