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Orbital Infantile Hemangioma
Surjith Vattoth, MD, FRCR; Daniel E. Meltzer, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Orbital capillary hemangioma, infantile periocular hemangioma
              • Definitions

                • Benign vascular tumor of infancy
                • Distinct lesion from vascular malformation

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Angiographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                • Reporting Tips

                                                  Selected References

                                                  1. Ford JR et al: Early orbital infantile hemangioma that emphasizes the importance of glucose-transporter-1 (GLUT-1). Can J Ophthalmol. 53(2):e58-60, 2018
                                                  2. Kralik SF et al: Orbital infantile hemangioma and rhabdomyosarcoma in children: differentiation using diffusion-weighted magnetic resonance imaging. J AAPOS. 22(1):27-31, 2018
                                                  3. Stass-Isern M: Periorbital and orbital infantile hemangiomas. Int Ophthalmol Clin. 54(3):73-82, 2014
                                                  4. Xu S et al: Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids. J Paediatr Child Health. 50(4):271-9, 2014
                                                  5. Drolet BA et al: Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics. 131(1):128-40, 2013
                                                  6. Frank RC et al: Visual development in infants: visual complications of periocular haemangiomas. J Plast Reconstr Aesthet Surg. 63(1):1-8, 2010
                                                  7. Nguyen J et al: Pharmacologic therapy for periocular infantile hemangiomas: a review of the literature. Semin Ophthalmol. 24(3):178-84, 2009
                                                  8. Chan LK et al: The management of periorbital fat excess in haemangioma involution. J Plast Reconstr Aesthet Surg. 61(2):133-7, 2008
                                                  9. Léauté-Labrèze C et al: Propranolol for severe hemangiomas of infancy. N Engl J Med. 358(24):2649-51, 2008
                                                  10. Tronina SA et al: Combined surgical method of orbital and periorbital hemangioma treatment in infants. Orbit. 27(4):249-57, 2008
                                                  11. Weiss AH et al: Reappraisal of astigmatism induced by periocular capillary hemangioma and treatment with intralesional corticosteroid injection. Ophthalmology. 115(2):390-7, 2008
                                                  12. Chung EM et al: From the archives of the AFIP: pediatric orbit tumors and tumorlike lesions: nonosseous lesions of the extraocular orbit. Radiographics. 27(6):1777-99, 2007
                                                  13. Judd CD et al: Intracranial infantile hemangiomas associated with PHACE syndrome. AJNR Am J Neuroradiol. 28(1):25-9, 2007
                                                  14. Levi M et al: Surgical treatment of capillary hemangiomas causing amblyopia. J AAPOS. 11(3):230-4, 2007
                                                  15. Reddy AR et al: Is this really a capillary haemangioma? Orbit. 26(4):327-9, 2007
                                                  16. Dubois J et al: Orbit and eyelid hemangiomas: is there a relationship between location and ocular problems? J Am Acad Dermatol. 55(4):614-9, 2006
                                                  17. Kavanagh EC et al: Imaging of the natural history of an orbital capillary hemangioma. Orbit. 25(1):69-72, 2006
                                                  18. Schwartz SR et al: Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J AAPOS. 10(3):262-8, 2006
                                                  19. Verity DH et al: Natural history of periocular capillary haemangiomas: changes in internal blood velocity and lesion volume. Eye. 20(10):1228-37, 2006
                                                  20. Ersoy S et al: Hemifacial infantile hemangioma with intracranial extension: a rare entity. Pediatr Dermatol. 22(4):309-13, 2005
                                                  21. Neudorfer M et al: Intraorbital and periorbital tumors in children--value of ultrasound and color Doppler imaging in the differential diagnosis. Am J Ophthalmol. 137(6):1065-72, 2004
                                                  22. Castillo BV Jr et al: Pediatric tumors of the eye and orbit. Pediatr Clin North Am. 50(1):149-72, 2003
                                                  23. O'Keefe M et al: Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. Acta Ophthalmol Scand. 81(3):294-8, 2003
                                                  24. Rootman J: Vascular malformations of the orbit: hemodynamic concepts. Orbit. 22(2):103-20, 2003
                                                  25. Waner M et al: The nonrandom distribution of facial hemangiomas. Arch Dermatol. 139(7):869-75, 2003
                                                  26. Sleep TJ et al: Doppler ultrasonography to aid diagnosis of orbital capillary haemangioma in neonates. Eye. 16(3):316-9, 2002
                                                  27. Bilaniuk LT: Orbital vascular lesions. Role of imaging. Radiol Clin North Am. 37(1):169-83, xi, 1999
                                                  28. Harris GJ: Orbital vascular malformations: a consensus statement on terminology and its clinical implications. Orbital Society. Am J Ophthalmol. 127(4):453-5, 1999
                                                  29. Walter JW et al: Genetic mapping of a novel familial form of infantile hemangioma. Am J Med Genet. 82(1):77-83, 1999
                                                  30. Forbes G: Vascular lesions in the orbit. Neuroimaging Clin N Am. 6(1):113-22, 1996
                                                  31. Rootman J et al: Multidisciplinary approaches to complicated vascular lesions of the orbit. Ophthalmology. 99(9):1440-6, 1992
                                                  32. Mafee MF et al: Dynamic computed tomography and its application to ophthalmology. Radiol Clin North Am. 25(4):715-31, 1987
                                                  33. Mafee MF et al: Orbital space-occupying lesions: role of computed tomography and magnetic resonance imaging. An analysis of 145 cases. Radiol Clin North Am. 25(3):529-59, 1987
                                                  34. Sklar EL et al: Correlative study of the computed tomographic, ultrasonographic, and pathological characteristics of cavernous versus capillary hemangiomas of the orbit. J Clin Neuroophthalmol. 6(1):14-21, 1986
                                                  35. Mulliken JB et al: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69(3):412-22, 1982
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Synonyms

                                                                • Orbital capillary hemangioma, infantile periocular hemangioma
                                                              • Definitions

                                                                • Benign vascular tumor of infancy
                                                                • Distinct lesion from vascular malformation

                                                              IMAGING

                                                              • General Features

                                                                • CT Findings

                                                                  • MR Findings

                                                                    • Ultrasonographic Findings

                                                                      • Angiographic Findings

                                                                        • Imaging Recommendations

                                                                          DIFFERENTIAL DIAGNOSIS

                                                                            PATHOLOGY

                                                                            • General Features

                                                                              • Staging, Grading, & Classification

                                                                                • Gross Pathologic & Surgical Features

                                                                                  • Microscopic Features

                                                                                    CLINICAL ISSUES

                                                                                    • Presentation

                                                                                      • Demographics

                                                                                        • Natural History & Prognosis

                                                                                          • Treatment

                                                                                            DIAGNOSTIC CHECKLIST

                                                                                            • Consider

                                                                                              • Image Interpretation Pearls

                                                                                                • Reporting Tips

                                                                                                  Selected References

                                                                                                  1. Ford JR et al: Early orbital infantile hemangioma that emphasizes the importance of glucose-transporter-1 (GLUT-1). Can J Ophthalmol. 53(2):e58-60, 2018
                                                                                                  2. Kralik SF et al: Orbital infantile hemangioma and rhabdomyosarcoma in children: differentiation using diffusion-weighted magnetic resonance imaging. J AAPOS. 22(1):27-31, 2018
                                                                                                  3. Stass-Isern M: Periorbital and orbital infantile hemangiomas. Int Ophthalmol Clin. 54(3):73-82, 2014
                                                                                                  4. Xu S et al: Treatment of periorbital infantile haemangiomas: a systematic literature review on propranolol or steroids. J Paediatr Child Health. 50(4):271-9, 2014
                                                                                                  5. Drolet BA et al: Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics. 131(1):128-40, 2013
                                                                                                  6. Frank RC et al: Visual development in infants: visual complications of periocular haemangiomas. J Plast Reconstr Aesthet Surg. 63(1):1-8, 2010
                                                                                                  7. Nguyen J et al: Pharmacologic therapy for periocular infantile hemangiomas: a review of the literature. Semin Ophthalmol. 24(3):178-84, 2009
                                                                                                  8. Chan LK et al: The management of periorbital fat excess in haemangioma involution. J Plast Reconstr Aesthet Surg. 61(2):133-7, 2008
                                                                                                  9. Léauté-Labrèze C et al: Propranolol for severe hemangiomas of infancy. N Engl J Med. 358(24):2649-51, 2008
                                                                                                  10. Tronina SA et al: Combined surgical method of orbital and periorbital hemangioma treatment in infants. Orbit. 27(4):249-57, 2008
                                                                                                  11. Weiss AH et al: Reappraisal of astigmatism induced by periocular capillary hemangioma and treatment with intralesional corticosteroid injection. Ophthalmology. 115(2):390-7, 2008
                                                                                                  12. Chung EM et al: From the archives of the AFIP: pediatric orbit tumors and tumorlike lesions: nonosseous lesions of the extraocular orbit. Radiographics. 27(6):1777-99, 2007
                                                                                                  13. Judd CD et al: Intracranial infantile hemangiomas associated with PHACE syndrome. AJNR Am J Neuroradiol. 28(1):25-9, 2007
                                                                                                  14. Levi M et al: Surgical treatment of capillary hemangiomas causing amblyopia. J AAPOS. 11(3):230-4, 2007
                                                                                                  15. Reddy AR et al: Is this really a capillary haemangioma? Orbit. 26(4):327-9, 2007
                                                                                                  16. Dubois J et al: Orbit and eyelid hemangiomas: is there a relationship between location and ocular problems? J Am Acad Dermatol. 55(4):614-9, 2006
                                                                                                  17. Kavanagh EC et al: Imaging of the natural history of an orbital capillary hemangioma. Orbit. 25(1):69-72, 2006
                                                                                                  18. Schwartz SR et al: Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J AAPOS. 10(3):262-8, 2006
                                                                                                  19. Verity DH et al: Natural history of periocular capillary haemangiomas: changes in internal blood velocity and lesion volume. Eye. 20(10):1228-37, 2006
                                                                                                  20. Ersoy S et al: Hemifacial infantile hemangioma with intracranial extension: a rare entity. Pediatr Dermatol. 22(4):309-13, 2005
                                                                                                  21. Neudorfer M et al: Intraorbital and periorbital tumors in children--value of ultrasound and color Doppler imaging in the differential diagnosis. Am J Ophthalmol. 137(6):1065-72, 2004
                                                                                                  22. Castillo BV Jr et al: Pediatric tumors of the eye and orbit. Pediatr Clin North Am. 50(1):149-72, 2003
                                                                                                  23. O'Keefe M et al: Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid. Acta Ophthalmol Scand. 81(3):294-8, 2003
                                                                                                  24. Rootman J: Vascular malformations of the orbit: hemodynamic concepts. Orbit. 22(2):103-20, 2003
                                                                                                  25. Waner M et al: The nonrandom distribution of facial hemangiomas. Arch Dermatol. 139(7):869-75, 2003
                                                                                                  26. Sleep TJ et al: Doppler ultrasonography to aid diagnosis of orbital capillary haemangioma in neonates. Eye. 16(3):316-9, 2002
                                                                                                  27. Bilaniuk LT: Orbital vascular lesions. Role of imaging. Radiol Clin North Am. 37(1):169-83, xi, 1999
                                                                                                  28. Harris GJ: Orbital vascular malformations: a consensus statement on terminology and its clinical implications. Orbital Society. Am J Ophthalmol. 127(4):453-5, 1999
                                                                                                  29. Walter JW et al: Genetic mapping of a novel familial form of infantile hemangioma. Am J Med Genet. 82(1):77-83, 1999
                                                                                                  30. Forbes G: Vascular lesions in the orbit. Neuroimaging Clin N Am. 6(1):113-22, 1996
                                                                                                  31. Rootman J et al: Multidisciplinary approaches to complicated vascular lesions of the orbit. Ophthalmology. 99(9):1440-6, 1992
                                                                                                  32. Mafee MF et al: Dynamic computed tomography and its application to ophthalmology. Radiol Clin North Am. 25(4):715-31, 1987
                                                                                                  33. Mafee MF et al: Orbital space-occupying lesions: role of computed tomography and magnetic resonance imaging. An analysis of 145 cases. Radiol Clin North Am. 25(3):529-59, 1987
                                                                                                  34. Sklar EL et al: Correlative study of the computed tomographic, ultrasonographic, and pathological characteristics of cavernous versus capillary hemangiomas of the orbit. J Clin Neuroophthalmol. 6(1):14-21, 1986
                                                                                                  35. Mulliken JB et al: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69(3):412-22, 1982