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Orbital Sarcoidosis
Philip R. Chapman, MD; H. Christian Davidson, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Ocular sarcoidosis
              • Definitions

                • Noncaseating, granulomatous inflammation of orbit

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Henderson AD et al: Neuro-ophthalmic manifestations of sarcoidosis. J Neuroophthalmol. ePub, 2020
                                          2. Mochizuki M et al: Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis. Br J Ophthalmol. 103(10):1418-22, 2019
                                          3. Acharya NR et al: Distinguishing features of ocular sarcoidosis in an international cohort of uveitis patients. Ophthalmology. 125(1):119-26, 2018
                                          4. Groen F et al: Ocular involvement in sarcoidosis. Semin Respir Crit Care Med. 38(4):514-22, 2017
                                          5. Kefella H et al: Ophthalmic and neuro-ophthalmic manifestations of sarcoidosis. Curr Opin Ophthalmol. 28(6):587-94, 2017
                                          6. Li CQ et al: Magnetic resonance imaging of uveitis. Neuroradiology. 57(8):825-32, 2015
                                          7. Rosenbaum JT et al: Parallel gene expression changes in sarcoidosis involving the lacrimal gland, orbital tissue, or blood. JAMA Ophthalmol. 133(7):770-7, 2015
                                          8. Demirci H et al: Orbital and adnexal involvement in sarcoidosis: analysis of clinical features and systemic disease in 30 cases. Am J Ophthalmol. 151(6):1074-80, 2011
                                          9. Mavrikakis I et al: Diverse clinical presentations of orbital sarcoid. Am J Ophthalmol. 144(5):769-775, 2007
                                          10. Prabhakaran VC et al: Orbital and adnexal sarcoidosis. Arch Ophthalmol. 125(12):1657-62, 2007
                                          11. Yamada R et al: Assessment of blood flow in orbital arteries in ocular sarcoidosis. Curr Eye Res. 24(3):219-23, 2002
                                          12. Simon EM et al: Systemic sarcoidosis with bilateral orbital involvement: MR findings. AJNR Am J Neuroradiol. 19(2):336-7, 1998
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • Ocular sarcoidosis
                                                      • Definitions

                                                        • Noncaseating, granulomatous inflammation of orbit

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Henderson AD et al: Neuro-ophthalmic manifestations of sarcoidosis. J Neuroophthalmol. ePub, 2020
                                                                                  2. Mochizuki M et al: Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis. Br J Ophthalmol. 103(10):1418-22, 2019
                                                                                  3. Acharya NR et al: Distinguishing features of ocular sarcoidosis in an international cohort of uveitis patients. Ophthalmology. 125(1):119-26, 2018
                                                                                  4. Groen F et al: Ocular involvement in sarcoidosis. Semin Respir Crit Care Med. 38(4):514-22, 2017
                                                                                  5. Kefella H et al: Ophthalmic and neuro-ophthalmic manifestations of sarcoidosis. Curr Opin Ophthalmol. 28(6):587-94, 2017
                                                                                  6. Li CQ et al: Magnetic resonance imaging of uveitis. Neuroradiology. 57(8):825-32, 2015
                                                                                  7. Rosenbaum JT et al: Parallel gene expression changes in sarcoidosis involving the lacrimal gland, orbital tissue, or blood. JAMA Ophthalmol. 133(7):770-7, 2015
                                                                                  8. Demirci H et al: Orbital and adnexal involvement in sarcoidosis: analysis of clinical features and systemic disease in 30 cases. Am J Ophthalmol. 151(6):1074-80, 2011
                                                                                  9. Mavrikakis I et al: Diverse clinical presentations of orbital sarcoid. Am J Ophthalmol. 144(5):769-775, 2007
                                                                                  10. Prabhakaran VC et al: Orbital and adnexal sarcoidosis. Arch Ophthalmol. 125(12):1657-62, 2007
                                                                                  11. Yamada R et al: Assessment of blood flow in orbital arteries in ocular sarcoidosis. Curr Eye Res. 24(3):219-23, 2002
                                                                                  12. Simon EM et al: Systemic sarcoidosis with bilateral orbital involvement: MR findings. AJNR Am J Neuroradiol. 19(2):336-7, 1998