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Orbitofrontal Cortex (Area 11)
Jeffrey S. Anderson, MD, PhD; Jared A. Nielsen, PhD
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Location and Boundaries

  • Location

    • Boundaries

      • Divisions

        Function

        • Emotional Processing

          • Decision Making and Prediction

            • Response Inhibition

              • Valuation, Reward, and Adaptive Behavior

                • Multimodal Sensory Integration and Hedonic Experience

                  Structural Connections

                  • Medial Orbitofrontal

                    • Lateral Orbitofrontal

                      Functional Connections

                      • Coactive Regions

                        • Associated Literature Keywords (NeuroSynth)

                          Area 11-Associated Disorders

                          • Traumatic Brain Injury

                            • Frontal Sinus Disorders

                              • Addiction

                                • Bilateral Orbitofrontal Injury

                                  Selected References

                                  1. Saez RA et al: Distinct roles for the amygdala and orbitofrontal cortex in representing the relative amount of expected reward. Neuron. 95(1):70-77.e3, 2017
                                  2. Stalnaker TA et al: What the orbitofrontal cortex does not do. Nat Neurosci. 18(5):620-7, 2015
                                  3. Smith DG et al: Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users. Biol Psychiatry. 75(2):124-31, 2014
                                  4. Wilson RC et al: Orbitofrontal cortex as a cognitive map of task space. Neuron. 81(2):267-279, 2014
                                  5. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                                  6. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                                  7. Uylings HB et al: 3-D cytoarchitectonic parcellation of human orbitofrontal cortex correlation with postmortem MRI. Psychiatry Res. 183(1):1-20, 2010
                                  8. Schoenbaum G et al: A new perspective on the role of the orbitofrontal cortex in adaptive behaviour. Nat Rev Neurosci. 10(12):885-92, 2009
                                  9. Kringelbach ML: The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 6(9):691-702, 2005
                                  10. Hornak J et al: Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci. 16(3):463-78, 2004
                                  11. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                                  12. O'Doherty J et al: Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci. 4(1):95-102, 2001
                                  13. Bechara A et al: Emotion, decision making and the orbitofrontal cortex. Cereb Cortex. 10(3):295-307, 2000
                                  14. Cavada C et al: The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb Cortex. 10(3):220-42, 2000
                                  15. Volkow ND et al: Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex. 10(3):318-25, 2000
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  Location and Boundaries

                                  • Location

                                    • Boundaries

                                      • Divisions

                                        Function

                                        • Emotional Processing

                                          • Decision Making and Prediction

                                            • Response Inhibition

                                              • Valuation, Reward, and Adaptive Behavior

                                                • Multimodal Sensory Integration and Hedonic Experience

                                                  Structural Connections

                                                  • Medial Orbitofrontal

                                                    • Lateral Orbitofrontal

                                                      Functional Connections

                                                      • Coactive Regions

                                                        • Associated Literature Keywords (NeuroSynth)

                                                          Area 11-Associated Disorders

                                                          • Traumatic Brain Injury

                                                            • Frontal Sinus Disorders

                                                              • Addiction

                                                                • Bilateral Orbitofrontal Injury

                                                                  Selected References

                                                                  1. Saez RA et al: Distinct roles for the amygdala and orbitofrontal cortex in representing the relative amount of expected reward. Neuron. 95(1):70-77.e3, 2017
                                                                  2. Stalnaker TA et al: What the orbitofrontal cortex does not do. Nat Neurosci. 18(5):620-7, 2015
                                                                  3. Smith DG et al: Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users. Biol Psychiatry. 75(2):124-31, 2014
                                                                  4. Wilson RC et al: Orbitofrontal cortex as a cognitive map of task space. Neuron. 81(2):267-279, 2014
                                                                  5. Van Essen DC et al: Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. Cereb Cortex. 22(10):2241-62, 2012
                                                                  6. Marcus DS et al: Informatics and data mining tools and strategies for the human connectome project. Front Neuroinform. 5:4, 2011
                                                                  7. Uylings HB et al: 3-D cytoarchitectonic parcellation of human orbitofrontal cortex correlation with postmortem MRI. Psychiatry Res. 183(1):1-20, 2010
                                                                  8. Schoenbaum G et al: A new perspective on the role of the orbitofrontal cortex in adaptive behaviour. Nat Rev Neurosci. 10(12):885-92, 2009
                                                                  9. Kringelbach ML: The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 6(9):691-702, 2005
                                                                  10. Hornak J et al: Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci. 16(3):463-78, 2004
                                                                  11. Maldjian JA et al: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19(3):1233-9, 2003
                                                                  12. O'Doherty J et al: Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci. 4(1):95-102, 2001
                                                                  13. Bechara A et al: Emotion, decision making and the orbitofrontal cortex. Cereb Cortex. 10(3):295-307, 2000
                                                                  14. Cavada C et al: The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb Cortex. 10(3):220-42, 2000
                                                                  15. Volkow ND et al: Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex. 10(3):318-25, 2000