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Organizing Pneumonia
Santiago Martínez-Jiménez, MD; Paul P. Pettavel, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Organizing pneumonia (OP)
                • Cryptogenic organizing pneumonia (COP)
                • Acute fibrinous and organizing pneumonia (AFOP)
                • Granulomatous organizing pneumonia (GOP)
              • Synonyms

                • Bronchiolitis obliterans organizing pneumonia formerly synonym for COP, but term no longer used
              • Definitions

                • OP, AFOP, and GOP: Related histologic patterns of lung reaction resulting from variety of insults
                  • AFOP considered acute pattern similar to diffuse alveolar damage (DAD)
                    • Subacute cases of AFOP may behave clinically like OP
                • COP: Idiopathic OP
                  • Nonspecific pulmonary reaction of unknown etiology

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Diagnosis

                                    • Natural HIstory and Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Saxena P et al: Acute fibrinous and organizing pneumonia: A rare form of nonbacterial pneumonia. Indian J Crit Care Med. 20(4):245-7, 2016
                                          2. Feinstein MB et al: A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia. J Clin Pathol. 68(6):441-7, 2015
                                          3. Kligerman SJ et al: From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 33(7):1951-75, 2013
                                          4. Beasley MB: The pathologist's approach to acute lung injury. Arch Pathol Lab Med. 134(5):719-27, 2010
                                          5. Beasley MB et al: Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 126(9):1064-70, 2002
                                          6. Yoshinouchi T et al: Clinicopathological study on two types of cryptogenic organizing pneumonitis. Respir Med. 89(4):271-8, 1995
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Organizing pneumonia (OP)
                                                        • Cryptogenic organizing pneumonia (COP)
                                                        • Acute fibrinous and organizing pneumonia (AFOP)
                                                        • Granulomatous organizing pneumonia (GOP)
                                                      • Synonyms

                                                        • Bronchiolitis obliterans organizing pneumonia formerly synonym for COP, but term no longer used
                                                      • Definitions

                                                        • OP, AFOP, and GOP: Related histologic patterns of lung reaction resulting from variety of insults
                                                          • AFOP considered acute pattern similar to diffuse alveolar damage (DAD)
                                                            • Subacute cases of AFOP may behave clinically like OP
                                                        • COP: Idiopathic OP
                                                          • Nonspecific pulmonary reaction of unknown etiology

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Diagnosis

                                                                            • Natural HIstory and Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Saxena P et al: Acute fibrinous and organizing pneumonia: A rare form of nonbacterial pneumonia. Indian J Crit Care Med. 20(4):245-7, 2016
                                                                                  2. Feinstein MB et al: A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia. J Clin Pathol. 68(6):441-7, 2015
                                                                                  3. Kligerman SJ et al: From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 33(7):1951-75, 2013
                                                                                  4. Beasley MB: The pathologist's approach to acute lung injury. Arch Pathol Lab Med. 134(5):719-27, 2010
                                                                                  5. Beasley MB et al: Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 126(9):1064-70, 2002
                                                                                  6. Yoshinouchi T et al: Clinicopathological study on two types of cryptogenic organizing pneumonitis. Respir Med. 89(4):271-8, 1995