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8
OVERVIEW
General Comments
Classification
PATHOLOGY
General Features
Gross Pathology & Surgical Features
Routes of Spread
Microscopic Features
IMAGING FINDINGS
Detection
Staging
CLINICAL ISSUES
Presentation
Cancer Natural History & Prognosis
Treatment Options
REPORTING CHECKLIST
T Staging
N Staging
M Staging
Selected References
Buckley L et al: HPV-related oropharyngeal carcinoma: a review of clinical and pathologic features with emphasis on updates in clinical and pathologic staging. Adv Anat Pathol. 25(3):180-88, 2018
Carpén T et al: Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients. Acta Otolaryngol. 138(5):513-18, 2018
Rash D et al: Treatment outcomes in HPV-negative oropharyngeal cancer: surgery plus radiotherapy vs. definitive chemoradiotherapy. Ear Nose Throat J. 97(8):E1-E7, 2018
Szyszko TA et al: PET/CT and PET/MRI in head and neck malignancy. Clin Radiol. 73(1):60-9, 2018
Amin M.B. et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
Duprez F et al: Distant metastases in head and neck cancer. Head Neck. 39(9):1733-43, 2017
Goel R et al: Clinical practice in PET/CT for the management of head and neck squamous cell cancer. AJR Am J Roentgenol. 209(2):289-303, 2017
Kelly JR et al: Comparison of survival outcomes among human papillomavirus-negative ct1-2 n1-2b patients with oropharyngeal squamous cell cancer treated with upfront surgery vs definitive chemoradiation therapy: an observational study. JAMA Oncol. 3(8):1107-1111, 2017
Lydiatt WM et al: Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(2):122-37, 2017
Wassef HR et al: PET/CT in head-neck malignancies: the implications for personalized clinical practice. PET Clin. 11(3):219-32, 2016
Dillon MT et al: Human papillomavirus-negative pharyngeal cancer. J Clin Oncol. 33(29):3251-61, 2015
Elrefaey S et al: HPV in oropharyngeal cancer: the basics to know in clinical practice. Acta Otorhinolaryngol Ital. 34(5):299-309, 2014
Kann BH et al: Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma. Head Neck. 36(12):1689-94, 2014
Tahari AK et al: FDG PET/CT imaging of oropharyngeal squamous cell carcinoma: characteristics of human papillomavirus-positive and -negative tumors. Clin Nucl Med. 39(3):225-31, 2014
Cantrell SC et al: Differences in imaging characteristics of HPV-positive and HPV-negative oropharyngeal cancers: a blinded matched-pair analysis. AJNR Am J Neuroradiol. 34(10):2005-9, 2013
Chernock RD: Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system. Head Neck Pathol. 6 Suppl 1:S41-7, 2012
Wang Y et al: Pathways for cervical metastasis in malignant neoplasms of the head and neck region. Clin Anat. 25(1):54-71, 2012
Wu Y et al: Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer: an analysis of the TAX 324 trial. Cancer. 118(7):1811-7, 2012
Guido A et al: Combined 18F-FDG-PET/CT imaging in radiotherapy target delineation for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 73(3):759-63, 2009
Ahuja AT et al: Ultrasound of malignant cervical lymph nodes. Cancer Imaging. 8:48-56, 2008
King AD et al: The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis. Br J Radiol. 81(964):291-8, 2008
Yen RF et al: Early restaging whole-body (18)F-FDG PET during induction chemotherapy predicts clinical outcome in patients with locoregionally advanced nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging. 32(10):1152-9, 2005
Vartanian JG et al: Distribution of metastatic lymph nodes in oropharyngeal carcinoma and its implications for the elective treatment of the neck. Arch Otolaryngol Head Neck Surg. 129(7):729-32, 2003
Werner JA et al: Functional anatomy of the lymphatic drainage system of the upper aerodigestive tract and its role in metastasis of squamous cell carcinoma. Head Neck. 25(4):322-32, 2003
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
OVERVIEW
General Comments
Classification
PATHOLOGY
General Features
Gross Pathology & Surgical Features
Routes of Spread
Microscopic Features
IMAGING FINDINGS
Detection
Staging
CLINICAL ISSUES
Presentation
Cancer Natural History & Prognosis
Treatment Options
REPORTING CHECKLIST
T Staging
N Staging
M Staging
Selected References
Buckley L et al: HPV-related oropharyngeal carcinoma: a review of clinical and pathologic features with emphasis on updates in clinical and pathologic staging. Adv Anat Pathol. 25(3):180-88, 2018
Carpén T et al: Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients. Acta Otolaryngol. 138(5):513-18, 2018
Rash D et al: Treatment outcomes in HPV-negative oropharyngeal cancer: surgery plus radiotherapy vs. definitive chemoradiotherapy. Ear Nose Throat J. 97(8):E1-E7, 2018
Szyszko TA et al: PET/CT and PET/MRI in head and neck malignancy. Clin Radiol. 73(1):60-9, 2018
Amin M.B. et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
Duprez F et al: Distant metastases in head and neck cancer. Head Neck. 39(9):1733-43, 2017
Goel R et al: Clinical practice in PET/CT for the management of head and neck squamous cell cancer. AJR Am J Roentgenol. 209(2):289-303, 2017
Kelly JR et al: Comparison of survival outcomes among human papillomavirus-negative ct1-2 n1-2b patients with oropharyngeal squamous cell cancer treated with upfront surgery vs definitive chemoradiation therapy: an observational study. JAMA Oncol. 3(8):1107-1111, 2017
Lydiatt WM et al: Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(2):122-37, 2017
Wassef HR et al: PET/CT in head-neck malignancies: the implications for personalized clinical practice. PET Clin. 11(3):219-32, 2016
Dillon MT et al: Human papillomavirus-negative pharyngeal cancer. J Clin Oncol. 33(29):3251-61, 2015
Elrefaey S et al: HPV in oropharyngeal cancer: the basics to know in clinical practice. Acta Otorhinolaryngol Ital. 34(5):299-309, 2014
Kann BH et al: Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma. Head Neck. 36(12):1689-94, 2014
Tahari AK et al: FDG PET/CT imaging of oropharyngeal squamous cell carcinoma: characteristics of human papillomavirus-positive and -negative tumors. Clin Nucl Med. 39(3):225-31, 2014
Cantrell SC et al: Differences in imaging characteristics of HPV-positive and HPV-negative oropharyngeal cancers: a blinded matched-pair analysis. AJNR Am J Neuroradiol. 34(10):2005-9, 2013
Chernock RD: Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system. Head Neck Pathol. 6 Suppl 1:S41-7, 2012
Wang Y et al: Pathways for cervical metastasis in malignant neoplasms of the head and neck region. Clin Anat. 25(1):54-71, 2012
Wu Y et al: Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer: an analysis of the TAX 324 trial. Cancer. 118(7):1811-7, 2012
Guido A et al: Combined 18F-FDG-PET/CT imaging in radiotherapy target delineation for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 73(3):759-63, 2009
Ahuja AT et al: Ultrasound of malignant cervical lymph nodes. Cancer Imaging. 8:48-56, 2008
King AD et al: The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis. Br J Radiol. 81(964):291-8, 2008
Yen RF et al: Early restaging whole-body (18)F-FDG PET during induction chemotherapy predicts clinical outcome in patients with locoregionally advanced nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging. 32(10):1152-9, 2005
Vartanian JG et al: Distribution of metastatic lymph nodes in oropharyngeal carcinoma and its implications for the elective treatment of the neck. Arch Otolaryngol Head Neck Surg. 129(7):729-32, 2003
Werner JA et al: Functional anatomy of the lymphatic drainage system of the upper aerodigestive tract and its role in metastasis of squamous cell carcinoma. Head Neck. 25(4):322-32, 2003
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