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Osteoblastoma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Osteoblastoma (OB)
          • Synonyms

            • Giant osteoid osteoma
              • Incorrect term, but emphasizes its histologic similarity to osteoid osteoma
            • Ossifying giant cell tumor
            • Osteogenic fibroma (outdated term)
          • Definitions

            • Rare, benign bone-forming tumor

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
                                      2. Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-E103, 2014
                                      3. Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
                                      4. Yin H et al: Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J. 23(2):411-6, 2014
                                      5. Al-Muqbel KM et al: Osteoblastoma is a metabolically active benign bone tumor on 18F-FDG PET imaging. J Nucl Med Technol. 41(4):308-10, 2013
                                      6. Baker AC et al: Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 18(3):219-24, 2010
                                      7. Kaya A et al: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg. 75(2):280-5, 2009
                                      8. Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med. 2(1):65-7, 2009
                                      9. Berry M et al: Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 98(3):179-83, 2008
                                      10. Chakrapani SD et al: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 33(25):E968-70, 2008
                                      11. Deyrup AT et al: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol. 16(3):308-10, 2008
                                      12. James SL et al: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol. 67(1):11-21, 2008
                                      13. Nishida K et al: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics. 31(4):403, 2008
                                      14. Tawil A et al: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 204(6):413-22, 2008
                                      15. Kyriakos M et al: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. 36(3):237-47, 2007
                                      16. Mortazavi SM et al: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol. 36(3):259-64, 2007
                                      17. Saglik Y et al: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 73(6):747-53, 2007
                                      18. Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
                                      19. Ozaki T et al: Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. (397):394-402, 2002
                                      20. Kroon HM et al: Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 175(3):783-90, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Osteoblastoma (OB)
                                              • Synonyms

                                                • Giant osteoid osteoma
                                                  • Incorrect term, but emphasizes its histologic similarity to osteoid osteoma
                                                • Ossifying giant cell tumor
                                                • Osteogenic fibroma (outdated term)
                                              • Definitions

                                                • Rare, benign bone-forming tumor

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
                                                                          2. Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-E103, 2014
                                                                          3. Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
                                                                          4. Yin H et al: Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J. 23(2):411-6, 2014
                                                                          5. Al-Muqbel KM et al: Osteoblastoma is a metabolically active benign bone tumor on 18F-FDG PET imaging. J Nucl Med Technol. 41(4):308-10, 2013
                                                                          6. Baker AC et al: Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 18(3):219-24, 2010
                                                                          7. Kaya A et al: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg. 75(2):280-5, 2009
                                                                          8. Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med. 2(1):65-7, 2009
                                                                          9. Berry M et al: Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 98(3):179-83, 2008
                                                                          10. Chakrapani SD et al: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 33(25):E968-70, 2008
                                                                          11. Deyrup AT et al: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol. 16(3):308-10, 2008
                                                                          12. James SL et al: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol. 67(1):11-21, 2008
                                                                          13. Nishida K et al: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics. 31(4):403, 2008
                                                                          14. Tawil A et al: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 204(6):413-22, 2008
                                                                          15. Kyriakos M et al: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. 36(3):237-47, 2007
                                                                          16. Mortazavi SM et al: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol. 36(3):259-64, 2007
                                                                          17. Saglik Y et al: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 73(6):747-53, 2007
                                                                          18. Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
                                                                          19. Ozaki T et al: Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. (397):394-402, 2002
                                                                          20. Kroon HM et al: Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 175(3):783-90, 1990