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Spine
Diagnosis
Neoplasms, Cysts, and Other Masses
Neoplasms
Extradural
Osteoblastoma
Osteoblastoma
Jeffrey S. Ross, MD; Kevin R. Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Definitions

                • Osteoblastoma (OB): Benign tumor that forms osteoid
                  • Differentiated grossly from osteoid osteoma by larger size (> 1.5 cm)

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Angiographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  Selected References

                                                  1. Mishra A et al: Cervical spine osteoblastoma with an aneurysmal bone cyst in a 2-year-old child: a case report. Pediatr Neurosurg. 54(1):46-50, 2019
                                                  2. Jia Q et al: Factors affecting prognosis of patients with osteoblastoma of the mobile spine: a long-term follow-up study of 70 patients in a single center. Neurosurgery. 86(1):71-9, 2018
                                                  3. Galgano MA et al: Osteoblastomas of the spine: a comprehensive review. Neurosurg Focus. 41(2):E4, 2016
                                                  4. Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
                                                  5. Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-103, 2014
                                                  6. Li Z et al: Clinical features and surgical management of spinal osteoblastoma: a retrospective study in 18 cases. PLoS One. 8(9):e74635, 2013
                                                  7. Singh DK et al: Aggressive osteoblastoma involving the craniovertebral junction: a case report and review of literature. J Craniovertebr Junction Spine. 4(2):69-72, 2013
                                                  8. Harrop JS et al: Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. Spine (Phila Pa 1976). 34(22 Suppl):S39-47, 2009
                                                  9. Qian BP et al: Spinal osteoblastoma complicated with epidural hematoma: two case reports. Spine (Phila Pa 1976). 34(12):E447-51, 2009
                                                  10. Kan P et al: Osteoid osteoma and osteoblastoma of the spine. Neurosurg Clin N Am. 19(1):65-70, 2008
                                                  11. Biagini R et al: Osteoid osteoma and osteoblastoma of the sacrum. Orthopedics. 24(11):1061-4, 2001
                                                  12. Okuda S et al: Ossification of the ligamentum flavum associated with osteoblastoma: a report of three cases. Skeletal Radiol. 30(7):402-6, 2001
                                                  13. Shaikh MI et al: Spinal osteoblastoma: CT and MR imaging with pathological correlation. Skeletal Radiol. 28(1):33-40, 1999
                                                  14. Saifuddin A et al: Osteoid osteoma and osteoblastoma of the spine. Factors associated with the presence of scoliosis. Spine. 23(1):47-53, 1998
                                                  15. Cheung FM et al: Diagnostic criteria for pseudomalignant osteoblastoma. Histopathology. 31(2):196-200, 1997
                                                  16. Murphey MD et al: From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation. Radiographics. 16(5):1131-58, 1996
                                                  17. Greenspan A: Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Skeletal Radiol. 22(7):485-500, 1993
                                                  18. Boriani S et al: Osteoblastoma of the spine. Clin Orthop Relat Res. (278):37-45, 1992
                                                  19. Crim JR et al: Widespread inflammatory response to osteoblastoma: the flare phenomenon. Radiology. 177(3):835-6, 1990
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Definitions

                                                                • Osteoblastoma (OB): Benign tumor that forms osteoid
                                                                  • Differentiated grossly from osteoid osteoma by larger size (> 1.5 cm)

                                                              IMAGING

                                                              • General Features

                                                                • Radiographic Findings

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Angiographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      CLINICAL ISSUES

                                                                                      • Presentation

                                                                                        • Demographics

                                                                                          • Natural History & Prognosis

                                                                                            • Treatment

                                                                                              DIAGNOSTIC CHECKLIST

                                                                                              • Consider

                                                                                                • Image Interpretation Pearls

                                                                                                  Selected References

                                                                                                  1. Mishra A et al: Cervical spine osteoblastoma with an aneurysmal bone cyst in a 2-year-old child: a case report. Pediatr Neurosurg. 54(1):46-50, 2019
                                                                                                  2. Jia Q et al: Factors affecting prognosis of patients with osteoblastoma of the mobile spine: a long-term follow-up study of 70 patients in a single center. Neurosurgery. 86(1):71-9, 2018
                                                                                                  3. Galgano MA et al: Osteoblastomas of the spine: a comprehensive review. Neurosurg Focus. 41(2):E4, 2016
                                                                                                  4. Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
                                                                                                  5. Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-103, 2014
                                                                                                  6. Li Z et al: Clinical features and surgical management of spinal osteoblastoma: a retrospective study in 18 cases. PLoS One. 8(9):e74635, 2013
                                                                                                  7. Singh DK et al: Aggressive osteoblastoma involving the craniovertebral junction: a case report and review of literature. J Craniovertebr Junction Spine. 4(2):69-72, 2013
                                                                                                  8. Harrop JS et al: Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. Spine (Phila Pa 1976). 34(22 Suppl):S39-47, 2009
                                                                                                  9. Qian BP et al: Spinal osteoblastoma complicated with epidural hematoma: two case reports. Spine (Phila Pa 1976). 34(12):E447-51, 2009
                                                                                                  10. Kan P et al: Osteoid osteoma and osteoblastoma of the spine. Neurosurg Clin N Am. 19(1):65-70, 2008
                                                                                                  11. Biagini R et al: Osteoid osteoma and osteoblastoma of the sacrum. Orthopedics. 24(11):1061-4, 2001
                                                                                                  12. Okuda S et al: Ossification of the ligamentum flavum associated with osteoblastoma: a report of three cases. Skeletal Radiol. 30(7):402-6, 2001
                                                                                                  13. Shaikh MI et al: Spinal osteoblastoma: CT and MR imaging with pathological correlation. Skeletal Radiol. 28(1):33-40, 1999
                                                                                                  14. Saifuddin A et al: Osteoid osteoma and osteoblastoma of the spine. Factors associated with the presence of scoliosis. Spine. 23(1):47-53, 1998
                                                                                                  15. Cheung FM et al: Diagnostic criteria for pseudomalignant osteoblastoma. Histopathology. 31(2):196-200, 1997
                                                                                                  16. Murphey MD et al: From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation. Radiographics. 16(5):1131-58, 1996
                                                                                                  17. Greenspan A: Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Skeletal Radiol. 22(7):485-500, 1993
                                                                                                  18. Boriani S et al: Osteoblastoma of the spine. Clin Orthop Relat Res. (278):37-45, 1992
                                                                                                  19. Crim JR et al: Widespread inflammatory response to osteoblastoma: the flare phenomenon. Radiology. 177(3):835-6, 1990