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Osteoblastoma
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Osteoblastoma (OB)
          • Synonyms

            • Epithelioid OB (formerly aggressive OB)
            • Outdated and not recommended: giant osteoid osteoma (OO), ossifying giant cell tumor, osteogenic fibroma, benign OB, pseudomalignant OB, aggressive OB
          • Definitions

            • Locally aggressive, bone-forming tumor > 2 cm
            • Though morphologically similar to OO, growth potential differentiates it from OO

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Amini B et al: Osteoid tumors of bone. Semin Ultrasound CT MR. 42(2):134-49, 2021
                                      2. Amary F et al. Osteoblastoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 397-9, 2020
                                      3. Gambarotti M et al: Osteoblastoma-like osteosarcoma: high-grade or low-grade osteosarcoma? Histopathology. 74(3):494-503, 2019
                                      4. Fittall MW et al: Recurrent rearrangements of FOS and FOSB define osteoblastoma. Nat Commun. 9(1):2150, 2018
                                      5. Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
                                      6. Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-103, 2014
                                      7. Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
                                      8. Yin H et al: Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J. 23(2):411-6, 2014
                                      9. Al-Muqbel KM et al: Osteoblastoma is a metabolically active benign bone tumor on 18F-FDG PET imaging. J Nucl Med Technol. 41(4):308-10, 2013
                                      10. Baker AC et al: Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 18(3):219-24, 2010
                                      11. Kaya A et al: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg. 75(2):280-5, 2009
                                      12. Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med. 2(1):65-7, 2009
                                      13. Berry M et al: Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 98(3):179-83, 2008
                                      14. Chakrapani SD et al: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 33(25):E968-70, 2008
                                      15. Deyrup AT et al: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol. 16(3):308-10, 2008
                                      16. James SL et al: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol. 67(1):11-21, 2008
                                      17. Nishida K et al: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics. 31(4):403, 2008
                                      18. Tawil A et al: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 204(6):413-22, 2008
                                      19. Kyriakos M et al: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. 36(3):237-47, 2007
                                      20. Mortazavi SM et al: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol. 36(3):259-64, 2007
                                      21. Saglik Y et al: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 73(6):747-53, 2007
                                      22. Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
                                      23. Ozaki T et al: Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. (397):394-402, 2002
                                      24. Kroon HM et al: Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 175(3):783-90, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Osteoblastoma (OB)
                                              • Synonyms

                                                • Epithelioid OB (formerly aggressive OB)
                                                • Outdated and not recommended: giant osteoid osteoma (OO), ossifying giant cell tumor, osteogenic fibroma, benign OB, pseudomalignant OB, aggressive OB
                                              • Definitions

                                                • Locally aggressive, bone-forming tumor > 2 cm
                                                • Though morphologically similar to OO, growth potential differentiates it from OO

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Amini B et al: Osteoid tumors of bone. Semin Ultrasound CT MR. 42(2):134-49, 2021
                                                                          2. Amary F et al. Osteoblastoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 397-9, 2020
                                                                          3. Gambarotti M et al: Osteoblastoma-like osteosarcoma: high-grade or low-grade osteosarcoma? Histopathology. 74(3):494-503, 2019
                                                                          4. Fittall MW et al: Recurrent rearrangements of FOS and FOSB define osteoblastoma. Nat Commun. 9(1):2150, 2018
                                                                          5. Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
                                                                          6. Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-103, 2014
                                                                          7. Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
                                                                          8. Yin H et al: Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J. 23(2):411-6, 2014
                                                                          9. Al-Muqbel KM et al: Osteoblastoma is a metabolically active benign bone tumor on 18F-FDG PET imaging. J Nucl Med Technol. 41(4):308-10, 2013
                                                                          10. Baker AC et al: Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 18(3):219-24, 2010
                                                                          11. Kaya A et al: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg. 75(2):280-5, 2009
                                                                          12. Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med. 2(1):65-7, 2009
                                                                          13. Berry M et al: Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 98(3):179-83, 2008
                                                                          14. Chakrapani SD et al: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 33(25):E968-70, 2008
                                                                          15. Deyrup AT et al: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol. 16(3):308-10, 2008
                                                                          16. James SL et al: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol. 67(1):11-21, 2008
                                                                          17. Nishida K et al: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics. 31(4):403, 2008
                                                                          18. Tawil A et al: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 204(6):413-22, 2008
                                                                          19. Kyriakos M et al: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. 36(3):237-47, 2007
                                                                          20. Mortazavi SM et al: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol. 36(3):259-64, 2007
                                                                          21. Saglik Y et al: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 73(6):747-53, 2007
                                                                          22. Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
                                                                          23. Ozaki T et al: Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. (397):394-402, 2002
                                                                          24. Kroon HM et al: Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 175(3):783-90, 1990