Outdated and not recommended: giant osteoid osteoma (OO), ossifying giant cell tumor, osteogenic fibroma, benign OB, pseudomalignant OB, aggressive OB
Definitions
Locally aggressive, bone-forming tumor > 2 cm
Though morphologically similar to OO, growth potential differentiates it from OO
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Amini B et al: Osteoid tumors of bone. Semin Ultrasound CT MR. 42(2):134-49, 2021
Amary F et al. Osteoblastoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 397-9, 2020
Gambarotti M et al: Osteoblastoma-like osteosarcoma: high-grade or low-grade osteosarcoma? Histopathology. 74(3):494-503, 2019
Fittall MW et al: Recurrent rearrangements of FOS and FOSB define osteoblastoma. Nat Commun. 9(1):2150, 2018
Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-103, 2014
Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
Yin H et al: Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J. 23(2):411-6, 2014
Al-Muqbel KM et al: Osteoblastoma is a metabolically active benign bone tumor on 18F-FDG PET imaging. J Nucl Med Technol. 41(4):308-10, 2013
Baker AC et al: Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 18(3):219-24, 2010
Kaya A et al: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg. 75(2):280-5, 2009
Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med. 2(1):65-7, 2009
Berry M et al: Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 98(3):179-83, 2008
Chakrapani SD et al: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 33(25):E968-70, 2008
Deyrup AT et al: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol. 16(3):308-10, 2008
James SL et al: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol. 67(1):11-21, 2008
Nishida K et al: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics. 31(4):403, 2008
Tawil A et al: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 204(6):413-22, 2008
Kyriakos M et al: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. 36(3):237-47, 2007
Mortazavi SM et al: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol. 36(3):259-64, 2007
Saglik Y et al: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 73(6):747-53, 2007
Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
Ozaki T et al: Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. (397):394-402, 2002
Kroon HM et al: Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 175(3):783-90, 1990
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Osteoblastoma (OB)
Synonyms
Epithelioid OB (formerly aggressive OB)
Outdated and not recommended: giant osteoid osteoma (OO), ossifying giant cell tumor, osteogenic fibroma, benign OB, pseudomalignant OB, aggressive OB
Definitions
Locally aggressive, bone-forming tumor > 2 cm
Though morphologically similar to OO, growth potential differentiates it from OO
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Amini B et al: Osteoid tumors of bone. Semin Ultrasound CT MR. 42(2):134-49, 2021
Amary F et al. Osteoblastoma. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 397-9, 2020
Gambarotti M et al: Osteoblastoma-like osteosarcoma: high-grade or low-grade osteosarcoma? Histopathology. 74(3):494-503, 2019
Fittall MW et al: Recurrent rearrangements of FOS and FOSB define osteoblastoma. Nat Commun. 9(1):2150, 2018
Orguc S et al: Primary tumors of the spine. Semin Musculoskelet Radiol. 18(3):280-99, 2014
Ruggieri P et al: Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine (Phila Pa 1976). 39(2):E97-103, 2014
Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
Yin H et al: Clinical characteristics and treatment options for two types of osteoblastoma in the mobile spine: a retrospective study of 32 cases and outcomes. Eur Spine J. 23(2):411-6, 2014
Al-Muqbel KM et al: Osteoblastoma is a metabolically active benign bone tumor on 18F-FDG PET imaging. J Nucl Med Technol. 41(4):308-10, 2013
Baker AC et al: Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 18(3):219-24, 2010
Kaya A et al: Periosteal osteoblastoma of the distal femur. Acta Orthop Belg. 75(2):280-5, 2009
Saccomanni B: Osteoid osteoma and osteoblastoma of the spine: a review of the literature. Curr Rev Musculoskelet Med. 2(1):65-7, 2009
Berry M et al: Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 98(3):179-83, 2008
Chakrapani SD et al: Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 33(25):E968-70, 2008
Deyrup AT et al: Aggressive (epithelioid) osteoblastoma arising in soft tissue. Int J Surg Pathol. 16(3):308-10, 2008
James SL et al: Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol. 67(1):11-21, 2008
Nishida K et al: Total en bloc spondylectomy in the treatment of aggressive osteoblastoma of the thoracic spine. Orthopedics. 31(4):403, 2008
Tawil A et al: Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 204(6):413-22, 2008
Kyriakos M et al: Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. 36(3):237-47, 2007
Mortazavi SM et al: Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature. Skeletal Radiol. 36(3):259-64, 2007
Saglik Y et al: Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 73(6):747-53, 2007
Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
Ozaki T et al: Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. (397):394-402, 2002
Kroon HM et al: Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 175(3):783-90, 1990
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