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Osteofibrous Dysplasia
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Osteofibrous dysplasia (OFD)
            • Synonyms

              • Ossifying fibroma, osteitis fibrosa cystica
              • Congenital fibrous defect of tibia, extragnathic ossifying fibroma, Kempson-Campanacci
            • Definitions

              • Fibroosseous lesion primarily affecting tibia and fibula of children

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Image-Guided Biopsy

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Reporting Tips

                                          Selected References

                                          1. Jung JY et al: MR findings of the osteofibrous dysplasia. Korean J Radiol. 15(1):114-22, 2014
                                          2. Wick MR et al: Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasms. Semin Diagn Pathol. 31(1):66-88, 2014
                                          3. Gleason BC et al: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 32(3):363-76, 2008
                                          4. Khanna M et al: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol. 37(12):1077-84, 2008
                                          5. Lee RS et al: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 88(5):658-64, 2006
                                          6. Van der Woude HJ et al: MRI of adamantinoma of long bones in correlation with histopathology. AJR Am J Roentgenol. 183(6):1737-44, 2004
                                          7. Kahn LB: Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skeletal Radiol. 32(5):245-58, 2003
                                          8. Seeger LL et al: Surface lesions of bone. Radiology. 206(1):17-33, 1998
                                          9. Nakashima Y et al: Osteofibrous dysplasia (ossifying fibroma of long bones). A study of 12 cases. Cancer. 52(5):909-14, 1983
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Osteofibrous dysplasia (OFD)
                                                    • Synonyms

                                                      • Ossifying fibroma, osteitis fibrosa cystica
                                                      • Congenital fibrous defect of tibia, extragnathic ossifying fibroma, Kempson-Campanacci
                                                    • Definitions

                                                      • Fibroosseous lesion primarily affecting tibia and fibula of children

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Image-Guided Biopsy

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Reporting Tips

                                                                                  Selected References

                                                                                  1. Jung JY et al: MR findings of the osteofibrous dysplasia. Korean J Radiol. 15(1):114-22, 2014
                                                                                  2. Wick MR et al: Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasms. Semin Diagn Pathol. 31(1):66-88, 2014
                                                                                  3. Gleason BC et al: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 32(3):363-76, 2008
                                                                                  4. Khanna M et al: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol. 37(12):1077-84, 2008
                                                                                  5. Lee RS et al: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 88(5):658-64, 2006
                                                                                  6. Van der Woude HJ et al: MRI of adamantinoma of long bones in correlation with histopathology. AJR Am J Roentgenol. 183(6):1737-44, 2004
                                                                                  7. Kahn LB: Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skeletal Radiol. 32(5):245-58, 2003
                                                                                  8. Seeger LL et al: Surface lesions of bone. Radiology. 206(1):17-33, 1998
                                                                                  9. Nakashima Y et al: Osteofibrous dysplasia (ossifying fibroma of long bones). A study of 12 cases. Cancer. 52(5):909-14, 1983