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Osteofibrous Dysplasia
Behrang Amini, MD, PhDB. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Osteofibrous dysplasia (OFD)
            • Synonyms

              • Not recommended: ossifying fibroma of long bones, Kempson-Campanacci lesion
            • Definitions

              • Benign fibroosseous tumor of childhood that typically arises in anterior cortex of tibia ± fibula

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Image-Guided Biopsy

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Reporting Tips

                                          Selected References

                                          1. Kamal AF et al: Osteofibrous dysplasia-like adamantinoma versus osteofibrous dysplasia in children: a case report of challenging diagnosis. Int J Surg Case Rep. 80:105599, 2021
                                          2. Deng Z et al: Outcome of osteofibrous dysplasia-like versus classic adamantinoma of long bones: a single-institution experience. J Orthop Surg Res. 15(1):268, 2020
                                          3. Nielsen N et al: Osteofibrous dysplasia. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 460-2, 2020
                                          4. Westacott D et al: Osteofibrous dysplasia of the tibia in children: outcome without resection. J Pediatr Orthop. 39(8):e614-21, 2019
                                          5. Ondhia M et al: Paediatric osteofibrous dysplasia-like adamantinoma with classical radiological findings. BMJ Case Rep. 2018, 2018
                                          6. Bethapudi S et al: Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. Clin Radiol. 69(2):200-8, 2014
                                          7. Jung JY et al: MR findings of the osteofibrous dysplasia. Korean J Radiol. 15(1):114-22, 2014
                                          8. Most MJ et al: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg. 18(6):358-66, 2010
                                          9. Gleason BC et al: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 32(3):363-76, 2008
                                          10. Khanna M et al: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol. 37(12):1077-84, 2008
                                          11. Lee RS et al: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 88(5):658-64, 2006
                                          12. Van der Woude HJ et al: MRI of adamantinoma of long bones in correlation with histopathology. AJR Am J Roentgenol. 183(6):1737-44, 2004
                                          13. Nakashima Y et al: Osteofibrous dysplasia (ossifying fibroma of long bones). A study of 12 cases. Cancer. 52(5):909-14, 1983
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Osteofibrous dysplasia (OFD)
                                                    • Synonyms

                                                      • Not recommended: ossifying fibroma of long bones, Kempson-Campanacci lesion
                                                    • Definitions

                                                      • Benign fibroosseous tumor of childhood that typically arises in anterior cortex of tibia ± fibula

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Image-Guided Biopsy

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Reporting Tips

                                                                                  Selected References

                                                                                  1. Kamal AF et al: Osteofibrous dysplasia-like adamantinoma versus osteofibrous dysplasia in children: a case report of challenging diagnosis. Int J Surg Case Rep. 80:105599, 2021
                                                                                  2. Deng Z et al: Outcome of osteofibrous dysplasia-like versus classic adamantinoma of long bones: a single-institution experience. J Orthop Surg Res. 15(1):268, 2020
                                                                                  3. Nielsen N et al: Osteofibrous dysplasia. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 460-2, 2020
                                                                                  4. Westacott D et al: Osteofibrous dysplasia of the tibia in children: outcome without resection. J Pediatr Orthop. 39(8):e614-21, 2019
                                                                                  5. Ondhia M et al: Paediatric osteofibrous dysplasia-like adamantinoma with classical radiological findings. BMJ Case Rep. 2018, 2018
                                                                                  6. Bethapudi S et al: Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. Clin Radiol. 69(2):200-8, 2014
                                                                                  7. Jung JY et al: MR findings of the osteofibrous dysplasia. Korean J Radiol. 15(1):114-22, 2014
                                                                                  8. Most MJ et al: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg. 18(6):358-66, 2010
                                                                                  9. Gleason BC et al: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 32(3):363-76, 2008
                                                                                  10. Khanna M et al: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol. 37(12):1077-84, 2008
                                                                                  11. Lee RS et al: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 88(5):658-64, 2006
                                                                                  12. Van der Woude HJ et al: MRI of adamantinoma of long bones in correlation with histopathology. AJR Am J Roentgenol. 183(6):1737-44, 2004
                                                                                  13. Nakashima Y et al: Osteofibrous dysplasia (ossifying fibroma of long bones). A study of 12 cases. Cancer. 52(5):909-14, 1983