Bookmarks
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Osteogenesis imperfecta (OI)
Synonyms
- Van der Hoeve-de Kleyn syndrome, fragilitas ossium, osteopsathyrosis, Lobstein disease, Vrolik disease
Definitions
- Group of clinically heterogeneous genetic disorders caused by type I collagen abnormalities
- ↑ bone fragility → frequent fractures → malunion & bowing
- Further ↑ likelihood of subsequent fractures
- Dentinogenesis imperfecta: Soft, cracked, discolored teeth
IMAGING
General Features
Radiographic Findings
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Anissipour AK et al: Behavior of scoliosis during growth in children with osteogenesis imperfecta. J Bone Joint Surg Am. 96(3):237-43, 2014
- Renaud A et al: Radiographic features of osteogenesis imperfecta. Insights Imaging. 4(4):417-29, 2013
- Akizawa Y et al: Prenatal diagnosis of osteogenesis imperfecta type II by three-dimensional computed tomography: the current state of fetal computed tomography. Congenit Anom (Kyoto). 52(4):203-6, 2012
- Bishop N: Characterising and treating osteogenesis imperfecta. Early Hum Dev. 86(11):743-6, 2010
- Van Dijk FS et al: Classification of osteogenesis imperfecta revisited. Eur J Med Genet. 53(1):1-5, 2010
- Shapiro JR et al: Osteogenesis imperfecta: questions and answers. Curr Opin Pediatr. 21(6):709-16, 2009
- Burnei G et al: Osteogenesis imperfecta: diagnosis and treatment. J Am Acad Orthop Surg. 16(6):356-66, 2008
- Cheung MS et al: Osteogenesis Imperfecta: update on presentation and management. Rev Endocr Metab Disord. 9(2):153-60, 2008
- Radfar L et al: Bisphosphonates, osteonecrosis of the jaw, and dental treatment recommendations. J Okla Dent Assoc. 99(7):28-9, 2008
- Ibrahim AG et al: Basilar impression and osteogenesis imperfecta: a 21-year retrospective review of outcomes in 20 patients. J Neurosurg Spine. 7(6):594-600, 2007
- Martin E et al: Osteogenesis imperfecta:epidemiology and pathophysiology. Curr Osteoporos Rep. 5(3):91-7, 2007
- Plotkin H: Syndromes with congenital brittle bones. BMC Pediatr. 4(1):16, 2004
- Rauch F et al: Osteogenesis imperfecta. Lancet. 363(9418):1377-85, 2004
- Tamborlane JW et al: Osteogenesis imperfecta presenting as simultaneous bilateral tibial tubercle avulsion fractures in a child: a case report. J Pediatr Orthop. 24(6):620-2, 2004
- Albayram S et al: Abnormalities in the cerebral arterial system in osteogenesis imperfecta. AJNR Am J Neuroradiol. 24(4):748-50, 2003
- Grissom LE et al: Radiographic features of bisphosphonate therapy in pediatric patients. Pediatr Radiol. 33(4):226-9, 2003
- Zeitlin L et al: Modern approach to children with osteogenesis imperfecta. J Pediatr Orthop B. 12(2):77-87, 2003
- Violas P et al: Acetabular protrusion in osteogenesis imperfecta. J Pediatr Orthop. 22(5):622-5, 2002
- Basu PS et al: Spondylolisthesis in osteogenesis imperfecta due to pedicle elongation: report of two cases. Spine. 26(21):E506-9, 2001
- Ablin DS: Osteogenesis imperfecta: a review. Can Assoc Radiol J. 49(2):110-23, 1998
- Herman TE et al: Inherited diseases of bone density in children. Radiol Clin North Am. 29(1):149-64, 1991
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Osteogenesis imperfecta (OI)
Synonyms
- Van der Hoeve-de Kleyn syndrome, fragilitas ossium, osteopsathyrosis, Lobstein disease, Vrolik disease
Definitions
- Group of clinically heterogeneous genetic disorders caused by type I collagen abnormalities
- ↑ bone fragility → frequent fractures → malunion & bowing
- Further ↑ likelihood of subsequent fractures
- Dentinogenesis imperfecta: Soft, cracked, discolored teeth
IMAGING
General Features
Radiographic Findings
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Anissipour AK et al: Behavior of scoliosis during growth in children with osteogenesis imperfecta. J Bone Joint Surg Am. 96(3):237-43, 2014
- Renaud A et al: Radiographic features of osteogenesis imperfecta. Insights Imaging. 4(4):417-29, 2013
- Akizawa Y et al: Prenatal diagnosis of osteogenesis imperfecta type II by three-dimensional computed tomography: the current state of fetal computed tomography. Congenit Anom (Kyoto). 52(4):203-6, 2012
- Bishop N: Characterising and treating osteogenesis imperfecta. Early Hum Dev. 86(11):743-6, 2010
- Van Dijk FS et al: Classification of osteogenesis imperfecta revisited. Eur J Med Genet. 53(1):1-5, 2010
- Shapiro JR et al: Osteogenesis imperfecta: questions and answers. Curr Opin Pediatr. 21(6):709-16, 2009
- Burnei G et al: Osteogenesis imperfecta: diagnosis and treatment. J Am Acad Orthop Surg. 16(6):356-66, 2008
- Cheung MS et al: Osteogenesis Imperfecta: update on presentation and management. Rev Endocr Metab Disord. 9(2):153-60, 2008
- Radfar L et al: Bisphosphonates, osteonecrosis of the jaw, and dental treatment recommendations. J Okla Dent Assoc. 99(7):28-9, 2008
- Ibrahim AG et al: Basilar impression and osteogenesis imperfecta: a 21-year retrospective review of outcomes in 20 patients. J Neurosurg Spine. 7(6):594-600, 2007
- Martin E et al: Osteogenesis imperfecta:epidemiology and pathophysiology. Curr Osteoporos Rep. 5(3):91-7, 2007
- Plotkin H: Syndromes with congenital brittle bones. BMC Pediatr. 4(1):16, 2004
- Rauch F et al: Osteogenesis imperfecta. Lancet. 363(9418):1377-85, 2004
- Tamborlane JW et al: Osteogenesis imperfecta presenting as simultaneous bilateral tibial tubercle avulsion fractures in a child: a case report. J Pediatr Orthop. 24(6):620-2, 2004
- Albayram S et al: Abnormalities in the cerebral arterial system in osteogenesis imperfecta. AJNR Am J Neuroradiol. 24(4):748-50, 2003
- Grissom LE et al: Radiographic features of bisphosphonate therapy in pediatric patients. Pediatr Radiol. 33(4):226-9, 2003
- Zeitlin L et al: Modern approach to children with osteogenesis imperfecta. J Pediatr Orthop B. 12(2):77-87, 2003
- Violas P et al: Acetabular protrusion in osteogenesis imperfecta. J Pediatr Orthop. 22(5):622-5, 2002
- Basu PS et al: Spondylolisthesis in osteogenesis imperfecta due to pedicle elongation: report of two cases. Spine. 26(21):E506-9, 2001
- Ablin DS: Osteogenesis imperfecta: a review. Can Assoc Radiol J. 49(2):110-23, 1998
- Herman TE et al: Inherited diseases of bone density in children. Radiol Clin North Am. 29(1):149-64, 1991
