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Osteoid Osteoma
A. Carlson Merrow, Jr., MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Osteoid osteoma (OO)
          • Definitions

            • Benign osteoblastic lesion characterized by < 2-cm nidus of osteoid/woven bone in fibrovascular tissue

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. French J et al: MR imaging of osteoid osteoma: pearls and pitfalls. Semin Ultrasound CT MR. 41(5):488-97, 2020
                                          2. Malghem J et al: Osteoid osteoma of the hip: imaging features. Skeletal Radiol. 49(11):1709-18, 2020
                                          3. Arrigoni F et al: Magnetic-resonance-guided focused ultrasound treatment of non-spinal osteoid osteoma in children: multicentre experience. Pediatr Radiol. 49(9):1209-16, 2019
                                          4. Baal JD et al: Factors associated with osteoid osteoma recurrence after CT-guided radiofrequency ablation. J Vasc Interv Radiol. 30(5):744-51, 2019
                                          5. Bhure U et al: Osteoid osteoma: multimodality imaging with focus on hybrid imaging. Eur J Nucl Med Mol Imaging. 46(4):1019-36, 2019
                                          6. Erbaş G et al: Treatment-related alterations of imaging findings in osteoid osteoma after percutaneous radiofrequency ablation. Skeletal Radiol. 48(11):1697-703, 2019
                                          7. Kaptan MA et al: Correlation of 3-T MRI and CT findings with patient symptoms and treatment outcome in radiofrequency ablation of osteoid osteoma. Acta Orthop Traumatol Turc. 53(4):239-47, 2019
                                          8. Kostrzewa M et al: Clinical and quantitative MRI perfusion analysis of osteoid osteomas before and after microwave ablation. Anticancer Res. 39(6):3053-7, 2019
                                          9. May CJ et al: Osteoid osteoma about the hip in children and adolescents. J Bone Joint Surg Am. 101(6):486-93, 2019
                                          10. Gurkan V et al: Foot and ankle osteoid osteomas. J Foot Ankle Surg. 57(4):826-32, 2018
                                          11. Hage AN et al: Percutaneous radiofrequency ablation for the treatment of osteoid osteoma in children and adults: a comparative analysis in 92 patients. Cardiovasc Intervent Radiol. 41(9):1384-90, 2018
                                          12. Santiago E et al: Percutaneous cryoablation for the treatment of osteoid osteoma in the adult population. Eur Radiol. 28(6):2336-44, 2018
                                          13. Kuyumcu G et al: Osteoid osteoma of the hand and foot in children successfully treated with radiofrequency neurotomy probes. Skeletal Radiol. 46(11):1561-5, 2017
                                          14. Laliotis NA et al: Osteoid osteoma of the acetabulum: diagnosis and medical treatment. J Pediatr Orthop B. 26(6):565-9, 2017
                                          15. Pottecher P et al: Dynamic contrast-enhanced MR imaging in osteoid osteoma: relationships with clinical and CT characteristics. Skeletal Radiol. 46(7):935-48, 2017
                                          16. Carra BJ et al: The half-moon sign of the femoral neck is nonspecific for the diagnosis of osteoid osteoma. AJR Am J Roentgenol. 206(3):W54, 2016
                                          17. Rheinheimer S et al: Diffusion weighted MRI of osteoid osteomas: higher ADC values after radiofrequency ablation. Eur J Radiol. 85(7):1284-8, 2016
                                          18. Klontzas ME et al: Osteoid osteoma of the femoral neck: use of the half-moon sign in MRI diagnosis. AJR Am J Roentgenol. 205(2):353-7, 2015
                                          19. Kotnis N et al: Imaging features of osteoid osteoma of the phalanges. Skeletal Radiol. 44(10):1461-6, 2015
                                          20. Song MH et al: Clinical and radiological features and skeletal sequelae in childhood intra-/juxta-articular versus extra-articular osteoid osteoma. BMC Musculoskelet Disord. 16:3, 2015
                                          21. Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
                                          22. Sharma P et al: 99mTc-Methylene diphosphonate SPECT/CT as the one-stop imaging modality for the diagnosis of osteoid osteoma. Nucl Med Commun. 35(8):876-83, 2014
                                          23. Boscainos PJ et al: Osteoid osteoma. Orthopedics. 36(10):792-800, 2013
                                          24. Yaniv G et al: Osteoid osteoma--the CT vessel sign. Skeletal Radiol. 40(10):1311-4, 2011
                                          25. Chai JW et al: Radiologic diagnosis of osteoid osteoma: from simple to challenging findings. Radiographics. 2010 May-Jun;30(3):737-49. Erratum in: Radiographics. 30(4):1156, 2010
                                          26. Zampa V et al: Osteoid osteoma in atypical locations: the added value of dynamic gadolinium-enhanced MR imaging. Eur J Radiol. 71(3):527-35, 2009
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Osteoid osteoma (OO)
                                                  • Definitions

                                                    • Benign osteoblastic lesion characterized by < 2-cm nidus of osteoid/woven bone in fibrovascular tissue

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. French J et al: MR imaging of osteoid osteoma: pearls and pitfalls. Semin Ultrasound CT MR. 41(5):488-97, 2020
                                                                                  2. Malghem J et al: Osteoid osteoma of the hip: imaging features. Skeletal Radiol. 49(11):1709-18, 2020
                                                                                  3. Arrigoni F et al: Magnetic-resonance-guided focused ultrasound treatment of non-spinal osteoid osteoma in children: multicentre experience. Pediatr Radiol. 49(9):1209-16, 2019
                                                                                  4. Baal JD et al: Factors associated with osteoid osteoma recurrence after CT-guided radiofrequency ablation. J Vasc Interv Radiol. 30(5):744-51, 2019
                                                                                  5. Bhure U et al: Osteoid osteoma: multimodality imaging with focus on hybrid imaging. Eur J Nucl Med Mol Imaging. 46(4):1019-36, 2019
                                                                                  6. Erbaş G et al: Treatment-related alterations of imaging findings in osteoid osteoma after percutaneous radiofrequency ablation. Skeletal Radiol. 48(11):1697-703, 2019
                                                                                  7. Kaptan MA et al: Correlation of 3-T MRI and CT findings with patient symptoms and treatment outcome in radiofrequency ablation of osteoid osteoma. Acta Orthop Traumatol Turc. 53(4):239-47, 2019
                                                                                  8. Kostrzewa M et al: Clinical and quantitative MRI perfusion analysis of osteoid osteomas before and after microwave ablation. Anticancer Res. 39(6):3053-7, 2019
                                                                                  9. May CJ et al: Osteoid osteoma about the hip in children and adolescents. J Bone Joint Surg Am. 101(6):486-93, 2019
                                                                                  10. Gurkan V et al: Foot and ankle osteoid osteomas. J Foot Ankle Surg. 57(4):826-32, 2018
                                                                                  11. Hage AN et al: Percutaneous radiofrequency ablation for the treatment of osteoid osteoma in children and adults: a comparative analysis in 92 patients. Cardiovasc Intervent Radiol. 41(9):1384-90, 2018
                                                                                  12. Santiago E et al: Percutaneous cryoablation for the treatment of osteoid osteoma in the adult population. Eur Radiol. 28(6):2336-44, 2018
                                                                                  13. Kuyumcu G et al: Osteoid osteoma of the hand and foot in children successfully treated with radiofrequency neurotomy probes. Skeletal Radiol. 46(11):1561-5, 2017
                                                                                  14. Laliotis NA et al: Osteoid osteoma of the acetabulum: diagnosis and medical treatment. J Pediatr Orthop B. 26(6):565-9, 2017
                                                                                  15. Pottecher P et al: Dynamic contrast-enhanced MR imaging in osteoid osteoma: relationships with clinical and CT characteristics. Skeletal Radiol. 46(7):935-48, 2017
                                                                                  16. Carra BJ et al: The half-moon sign of the femoral neck is nonspecific for the diagnosis of osteoid osteoma. AJR Am J Roentgenol. 206(3):W54, 2016
                                                                                  17. Rheinheimer S et al: Diffusion weighted MRI of osteoid osteomas: higher ADC values after radiofrequency ablation. Eur J Radiol. 85(7):1284-8, 2016
                                                                                  18. Klontzas ME et al: Osteoid osteoma of the femoral neck: use of the half-moon sign in MRI diagnosis. AJR Am J Roentgenol. 205(2):353-7, 2015
                                                                                  19. Kotnis N et al: Imaging features of osteoid osteoma of the phalanges. Skeletal Radiol. 44(10):1461-6, 2015
                                                                                  20. Song MH et al: Clinical and radiological features and skeletal sequelae in childhood intra-/juxta-articular versus extra-articular osteoid osteoma. BMC Musculoskelet Disord. 16:3, 2015
                                                                                  21. Yalcinkaya U et al: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. Ann Diagn Pathol. 18(6):319-25, 2014
                                                                                  22. Sharma P et al: 99mTc-Methylene diphosphonate SPECT/CT as the one-stop imaging modality for the diagnosis of osteoid osteoma. Nucl Med Commun. 35(8):876-83, 2014
                                                                                  23. Boscainos PJ et al: Osteoid osteoma. Orthopedics. 36(10):792-800, 2013
                                                                                  24. Yaniv G et al: Osteoid osteoma--the CT vessel sign. Skeletal Radiol. 40(10):1311-4, 2011
                                                                                  25. Chai JW et al: Radiologic diagnosis of osteoid osteoma: from simple to challenging findings. Radiographics. 2010 May-Jun;30(3):737-49. Erratum in: Radiographics. 30(4):1156, 2010
                                                                                  26. Zampa V et al: Osteoid osteoma in atypical locations: the added value of dynamic gadolinium-enhanced MR imaging. Eur J Radiol. 71(3):527-35, 2009