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Osteomyelitis and Septic Arthritis
Fathima Fijula P. Manzil, MD; Umesh D. Oza, MD; Brad Perry, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Osteomyelitis and septic arthritis: Infectious process causing progressive destruction of bone
              • Aggressive bone lesion with 1 or more of: Periosteal reaction, soft tissue swelling, subperiosteal abscess, or draining sinus
              • Septic arthritis occurs from direct inoculation or hematogenous spread

          IMAGING

          • Nuclear Medicine Findings

            • Imaging Recommendations

              • Artifacts and Quality Control

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Presentation

                      • Demographics

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Consider

                              • Image Interpretation Pearls

                                • Reporting Tips

                                  Selected References

                                  1. Arıcan P et al: Diagnostic value of bone SPECT/CT in patients with suspected osteomyelitis. Mol Imaging Radionucl Ther. 28(3):89-95, 2019
                                  2. Llewellyn A et al: Imaging tests for the detection of osteomyelitis: a systematic review. Health Technol Assess. 23(61):1-128, 2019
                                  3. Noriega-Álvarez E et al: Role of nuclear medicine in the diagnosis of musculoskeletal infection: a review. Rev Esp Med Nucl Imagen Mol. 38(6):397-407, 2019
                                  4. Love C et al: Radionuclide imaging of inflammation and infection in the acute care setting. Semin Nucl Med. 43(2):102-13, 2013
                                  5. Palestro CJ: FDG-PET in musculoskeletal infections. Semin Nucl Med. 43(5):367-76, 2013
                                  6. van der Bruggen W et al: PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 40(1):3-15, 2010
                                  7. Meller J et al: Nonprosthesis orthopedic applications of (18)F fluoro-2-deoxy-D-glucose PET in the detection of osteomyelitis. Radiol Clin North Am. 45(4):719-33, vii-viii, 2007
                                  8. Love C et al: Radionuclide bone imaging: an illustrative review. Radiographics. Mar-Apr;23(2):341-58, 2003
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Pathology

                                        • Diagnostic Checklist

                                          TERMINOLOGY

                                          • Definitions

                                            • Osteomyelitis and septic arthritis: Infectious process causing progressive destruction of bone
                                              • Aggressive bone lesion with 1 or more of: Periosteal reaction, soft tissue swelling, subperiosteal abscess, or draining sinus
                                              • Septic arthritis occurs from direct inoculation or hematogenous spread

                                          IMAGING

                                          • Nuclear Medicine Findings

                                            • Imaging Recommendations

                                              • Artifacts and Quality Control

                                                DIFFERENTIAL DIAGNOSIS

                                                  PATHOLOGY

                                                  • General Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Consider

                                                              • Image Interpretation Pearls

                                                                • Reporting Tips

                                                                  Selected References

                                                                  1. Arıcan P et al: Diagnostic value of bone SPECT/CT in patients with suspected osteomyelitis. Mol Imaging Radionucl Ther. 28(3):89-95, 2019
                                                                  2. Llewellyn A et al: Imaging tests for the detection of osteomyelitis: a systematic review. Health Technol Assess. 23(61):1-128, 2019
                                                                  3. Noriega-Álvarez E et al: Role of nuclear medicine in the diagnosis of musculoskeletal infection: a review. Rev Esp Med Nucl Imagen Mol. 38(6):397-407, 2019
                                                                  4. Love C et al: Radionuclide imaging of inflammation and infection in the acute care setting. Semin Nucl Med. 43(2):102-13, 2013
                                                                  5. Palestro CJ: FDG-PET in musculoskeletal infections. Semin Nucl Med. 43(5):367-76, 2013
                                                                  6. van der Bruggen W et al: PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 40(1):3-15, 2010
                                                                  7. Meller J et al: Nonprosthesis orthopedic applications of (18)F fluoro-2-deoxy-D-glucose PET in the detection of osteomyelitis. Radiol Clin North Am. 45(4):719-33, vii-viii, 2007
                                                                  8. Love C et al: Radionuclide bone imaging: an illustrative review. Radiographics. Mar-Apr;23(2):341-58, 2003