link
Bookmarks
Osteosarcoma
Andrew T. Trout, MD
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
13
24
0

KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Osteosarcoma (OS)
            • Synonyms

              • Osteogenic sarcoma
              • Telangiectatic osteosarcoma: Hemorrhagic OS, malignant bone aneurysm, aneurysmal bone cyst-like OS
              • Low-grade central osteosarcoma: Low-grade intramedullary OS, well-differentiated intramedullary OS, low-grade intraosseous-type OS
              • Parosteal osteosarcoma: Juxtacortical OS, juxtacortical low-grade OS, low-grade surface OS
            • Definitions

              • Primary malignant tumor of bone (mesenchymal origin) with cells producing osteoid
              • Subtypes (World Health Organization)
                • Conventional osteosarcoma: Most common (~ 75%)
                • Telangiectatic osteosarcoma (5-7%)
                • Secondary osteosarcoma
                • Small-cell osteosarcoma (1-2%)
                • Low-grade central osteosarcoma (1-2%)
                • Surface osteosarcoma
                  • Parosteal osteosarcoma (5%)
                  • Periosteal osteosarcoma (1-2%)
                  • High-grade surface type (1%)
            • Associated Syndromes

              • Predisposition with
                • Retinoblastoma gene mutation
                • Li-Fraumeni syndrome
                • Rothmund-Thompson syndrome
                • Mutations of p53 and MDM2 (murine double minute oncogene)
                • Chromosomal heterozygosity at 3q, 13q, and 18q
                • Other syndromes: Bloom, Werner, RAPADILINO

            IMAGING

            • General Features

              • Nuclear Medicine Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Roberts RD et al: Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. Cancer. 125(20):3514-25, 2019
                                      2. Song H et al: Can pretreatment 18F-FDG PET tumor texture features predict the outcomes of osteosarcoma treated by neoadjuvant chemotherapy? Eur Radiol. 29(7):3945-54, 2019
                                      3. Im HJ et al: Prognostic value of metabolic and volumetric parameters of FDG PET in pediatric osteosarcoma: A hypothesis-generating study. Radiology. 287(1):303-12, 2018
                                      4. Tamam C et al: Prognostic significance of maximum standardized uptake value on 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in bone sarcomas. Eklem Hastalik Cerrahisi. 29(3):184-8, 2018
                                      5. Reed DR et al: Treatment pathway of bone sarcoma in children, adolescents, and young adults. Cancer. 123(12):2206-2218, 2017
                                      6. Sharp SE et al: FDG PET/CT appearance of local osteosarcoma recurrences in pediatric patients. Pediatr Radiol. 47(13):1800-8, 2017
                                      7. Hurley C et al: Comparison of (18) F-FDG-PET-CT and bone scintigraphy for evaluation of osseous metastases in newly diagnosed and recurrent osteosarcoma. Pediatr Blood Cancer. 63(8):1381-6, 2016
                                      8. Quartuccio N et al: Pediatric bone sarcoma: diagnostic performance of ¹⁸F-FDG PET/CT versus conventional imaging for initial staging and follow-up. AJR Am J Roentgenol. 204(1):153-60, 2015
                                      9. Green JT et al: Osteogenic tumors of bone. Semin Diagn Pathol. 31(1):21-9, 2014
                                      10. Fox MG et al: Osteosarcoma: review of the various types with emphasis on recent advancements in imaging. Semin Musculoskelet Radiol. 17(2):123-36, 2013
                                      11. Hongtao L et al: 18F-FDG positron emission tomography for the assessment of histological response to neoadjuvant chemotherapy in osteosarcomas: a meta-analysis. Surg Oncol. 21(4):e165-70, 2012
                                      12. Inaki A et al: Thallium-201 scintigraphy for the assessment of long-term prognosis in patients with osteosarcoma. Ann Nucl Med. 26(7):545-50, 2012
                                      Related Anatomy
                                      Loading...
                                      Related Differential Diagnoses
                                      Loading...
                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Osteosarcoma (OS)
                                                • Synonyms

                                                  • Osteogenic sarcoma
                                                  • Telangiectatic osteosarcoma: Hemorrhagic OS, malignant bone aneurysm, aneurysmal bone cyst-like OS
                                                  • Low-grade central osteosarcoma: Low-grade intramedullary OS, well-differentiated intramedullary OS, low-grade intraosseous-type OS
                                                  • Parosteal osteosarcoma: Juxtacortical OS, juxtacortical low-grade OS, low-grade surface OS
                                                • Definitions

                                                  • Primary malignant tumor of bone (mesenchymal origin) with cells producing osteoid
                                                  • Subtypes (World Health Organization)
                                                    • Conventional osteosarcoma: Most common (~ 75%)
                                                    • Telangiectatic osteosarcoma (5-7%)
                                                    • Secondary osteosarcoma
                                                    • Small-cell osteosarcoma (1-2%)
                                                    • Low-grade central osteosarcoma (1-2%)
                                                    • Surface osteosarcoma
                                                      • Parosteal osteosarcoma (5%)
                                                      • Periosteal osteosarcoma (1-2%)
                                                      • High-grade surface type (1%)
                                                • Associated Syndromes

                                                  • Predisposition with
                                                    • Retinoblastoma gene mutation
                                                    • Li-Fraumeni syndrome
                                                    • Rothmund-Thompson syndrome
                                                    • Mutations of p53 and MDM2 (murine double minute oncogene)
                                                    • Chromosomal heterozygosity at 3q, 13q, and 18q
                                                    • Other syndromes: Bloom, Werner, RAPADILINO

                                                IMAGING

                                                • General Features

                                                  • Nuclear Medicine Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Roberts RD et al: Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. Cancer. 125(20):3514-25, 2019
                                                                          2. Song H et al: Can pretreatment 18F-FDG PET tumor texture features predict the outcomes of osteosarcoma treated by neoadjuvant chemotherapy? Eur Radiol. 29(7):3945-54, 2019
                                                                          3. Im HJ et al: Prognostic value of metabolic and volumetric parameters of FDG PET in pediatric osteosarcoma: A hypothesis-generating study. Radiology. 287(1):303-12, 2018
                                                                          4. Tamam C et al: Prognostic significance of maximum standardized uptake value on 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in bone sarcomas. Eklem Hastalik Cerrahisi. 29(3):184-8, 2018
                                                                          5. Reed DR et al: Treatment pathway of bone sarcoma in children, adolescents, and young adults. Cancer. 123(12):2206-2218, 2017
                                                                          6. Sharp SE et al: FDG PET/CT appearance of local osteosarcoma recurrences in pediatric patients. Pediatr Radiol. 47(13):1800-8, 2017
                                                                          7. Hurley C et al: Comparison of (18) F-FDG-PET-CT and bone scintigraphy for evaluation of osseous metastases in newly diagnosed and recurrent osteosarcoma. Pediatr Blood Cancer. 63(8):1381-6, 2016
                                                                          8. Quartuccio N et al: Pediatric bone sarcoma: diagnostic performance of ¹⁸F-FDG PET/CT versus conventional imaging for initial staging and follow-up. AJR Am J Roentgenol. 204(1):153-60, 2015
                                                                          9. Green JT et al: Osteogenic tumors of bone. Semin Diagn Pathol. 31(1):21-9, 2014
                                                                          10. Fox MG et al: Osteosarcoma: review of the various types with emphasis on recent advancements in imaging. Semin Musculoskelet Radiol. 17(2):123-36, 2013
                                                                          11. Hongtao L et al: 18F-FDG positron emission tomography for the assessment of histological response to neoadjuvant chemotherapy in osteosarcomas: a meta-analysis. Surg Oncol. 21(4):e165-70, 2012
                                                                          12. Inaki A et al: Thallium-201 scintigraphy for the assessment of long-term prognosis in patients with osteosarcoma. Ann Nucl Med. 26(7):545-50, 2012