Sarcoma containing osteoid matrix produced directly by malignant cells
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Parsai S et al: Spine radiosurgery in adolescents and young adults: early outcomes and toxicity in patients with metastatic Ewing sarcoma and osteosarcoma. J Neurosurg Spine. 1-8, 2019
Chen DJ et al: Lumbar spinal canal osteosarcoma: a case report. Medicine (Baltimore). 97(25):e11210, 2018
Noor Khairiah AK et al: Lumbosacral osteosarcoma with dural spread, skip lesions and intravascular extension: a case report. Med J Malaysia. 73(2):116-8, 2018
Shankar GM et al: The role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis. J Neurosurg Spine. 27(1):97-104, 2017
Zhou Z et al: Does rarity mean imparity? Biological characteristics of osteosarcoma cells originating from the spine. J Cancer Res Clin Oncol. 143(10):1959-69, 2017
Dekutoski MB et al: Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study. J Neurosurg Spine. 25(1):59-68, 2016
Groves ML et al: Epidemiologic, functional, and oncologic outcome analysis of spinal sarcomas treated surgically at a single institution over 10 years. Spine J. 15(1):110-4, 2014
Sadek AR et al: Multiple spinal osteochondromata and osteosarcoma in a patient with Gorlin's syndrome. Clin Neurol Neurosurg. 118:5-8, 2014
Smith JA et al: Locomotor biomechanics after total sacrectomy: a case report. Spine (Phila Pa 1976). 39(24):E1481-7, 2014
Bhatia R et al: Osteosarcoma of the spine: dismal past, any hope for the future? Br J Neurosurg. 28(4):495-502, 2013
Katonis P et al: Spinal osteosarcoma. Clin Med Insights Oncol. 7:199-208, 2013
Lim JB et al: Primary osteosarcoma of the spine: a review of 10 cases. Acta Orthop Belg. 79(4):457-62, 2013
Schiller MD et al: A case of intradural osteosarcoma of the spine. Spine J. 13(8):e55-8, 2013
Zils K et al: Osteosarcoma of the mobile spine. Ann Oncol. 24(8):2190-5, 2013
Sundaresan N et al: Primary malignant tumors of the spine. Orthop Clin North Am. 40(1):21-36, v, 2009
Kelley SP et al: Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J. 16(3):405-9, 2007
Ilaslan H et al: Primary vertebral osteosarcoma: imaging findings. Radiology. 230(3):697-702, 2004
Brenner W et al: PET imaging of osteosarcoma. J Nucl Med. 44(6):930-42, 2003
Aung L et al: Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center Experience. Cancer. 95(8):1728-34, 2002
Bredella MA et al: Value of FDG positron emission tomography in conjunction with MR imaging for evaluating therapy response in patients with musculoskeletal sarcomas. AJR Am J Roentgenol. 179(5):1145-50, 2002
Ozaki T et al: Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer. 94(4):1069-77, 2002
Iwata A et al: Osteosarcoma as a second malignancy after treatment for neuroblastoma. Pediatr Hematol Oncol. 18(7):465-9, 2001
Yamamoto T et al: Sacral radiculopathy secondary to multicentric osteosarcoma. Spine. 26(15):1729-32, 2001
Bramwell VH: Osteosarcomas and other cancers of bone. Curr Opin Oncol. 12(4):330-6, 2000
Vuillemin-Bodaghi V et al: Multifocal osteogenic sarcoma in Paget's disease. Skeletal Radiol. 29(6):349-53, 2000
Unni KK: Osteosarcoma of bone. J Orthop Sci. 3(5):287-94, 1998
Rosenberg ZS et al: Osteosarcoma: subtle, rare, and misleading plain film features. AJR Am J Roentgenol. 165(5):1209-14, 1995
Tigani D et al: Vertebral osteosarcoma. Ital J Orthop Traumatol. 14(1):5-13, 1988
Barwick KW et al: Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients. Cancer. 46(3):595-604, 1980
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Osteogenic sarcoma (OGS)
Definitions
Sarcoma containing osteoid matrix produced directly by malignant cells
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Parsai S et al: Spine radiosurgery in adolescents and young adults: early outcomes and toxicity in patients with metastatic Ewing sarcoma and osteosarcoma. J Neurosurg Spine. 1-8, 2019
Chen DJ et al: Lumbar spinal canal osteosarcoma: a case report. Medicine (Baltimore). 97(25):e11210, 2018
Noor Khairiah AK et al: Lumbosacral osteosarcoma with dural spread, skip lesions and intravascular extension: a case report. Med J Malaysia. 73(2):116-8, 2018
Shankar GM et al: The role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis. J Neurosurg Spine. 27(1):97-104, 2017
Zhou Z et al: Does rarity mean imparity? Biological characteristics of osteosarcoma cells originating from the spine. J Cancer Res Clin Oncol. 143(10):1959-69, 2017
Dekutoski MB et al: Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study. J Neurosurg Spine. 25(1):59-68, 2016
Groves ML et al: Epidemiologic, functional, and oncologic outcome analysis of spinal sarcomas treated surgically at a single institution over 10 years. Spine J. 15(1):110-4, 2014
Sadek AR et al: Multiple spinal osteochondromata and osteosarcoma in a patient with Gorlin's syndrome. Clin Neurol Neurosurg. 118:5-8, 2014
Smith JA et al: Locomotor biomechanics after total sacrectomy: a case report. Spine (Phila Pa 1976). 39(24):E1481-7, 2014
Bhatia R et al: Osteosarcoma of the spine: dismal past, any hope for the future? Br J Neurosurg. 28(4):495-502, 2013
Katonis P et al: Spinal osteosarcoma. Clin Med Insights Oncol. 7:199-208, 2013
Lim JB et al: Primary osteosarcoma of the spine: a review of 10 cases. Acta Orthop Belg. 79(4):457-62, 2013
Schiller MD et al: A case of intradural osteosarcoma of the spine. Spine J. 13(8):e55-8, 2013
Zils K et al: Osteosarcoma of the mobile spine. Ann Oncol. 24(8):2190-5, 2013
Sundaresan N et al: Primary malignant tumors of the spine. Orthop Clin North Am. 40(1):21-36, v, 2009
Kelley SP et al: Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J. 16(3):405-9, 2007
Ilaslan H et al: Primary vertebral osteosarcoma: imaging findings. Radiology. 230(3):697-702, 2004
Brenner W et al: PET imaging of osteosarcoma. J Nucl Med. 44(6):930-42, 2003
Aung L et al: Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center Experience. Cancer. 95(8):1728-34, 2002
Bredella MA et al: Value of FDG positron emission tomography in conjunction with MR imaging for evaluating therapy response in patients with musculoskeletal sarcomas. AJR Am J Roentgenol. 179(5):1145-50, 2002
Ozaki T et al: Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer. 94(4):1069-77, 2002
Iwata A et al: Osteosarcoma as a second malignancy after treatment for neuroblastoma. Pediatr Hematol Oncol. 18(7):465-9, 2001
Yamamoto T et al: Sacral radiculopathy secondary to multicentric osteosarcoma. Spine. 26(15):1729-32, 2001
Bramwell VH: Osteosarcomas and other cancers of bone. Curr Opin Oncol. 12(4):330-6, 2000
Vuillemin-Bodaghi V et al: Multifocal osteogenic sarcoma in Paget's disease. Skeletal Radiol. 29(6):349-53, 2000
Unni KK: Osteosarcoma of bone. J Orthop Sci. 3(5):287-94, 1998
Rosenberg ZS et al: Osteosarcoma: subtle, rare, and misleading plain film features. AJR Am J Roentgenol. 165(5):1209-14, 1995
Tigani D et al: Vertebral osteosarcoma. Ital J Orthop Traumatol. 14(1):5-13, 1988
Barwick KW et al: Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients. Cancer. 46(3):595-604, 1980
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