Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
- Heterogeneous group of malignant mesenchymal tumors
- 4th most common group of malignancies in children < 16 years old
- Most common pediatric soft tissue sarcoma: Rhabdomyosarcoma (~ 19-50%)
- Extraskeletal Ewing sarcoma/primitive neuroectodermal tumor & synovial sarcoma next most common
- Many other less common lesions
- Heterogeneous group of malignant mesenchymal tumors
Associated Syndromes
- Li-Fraumeni, Noonan, Beckwith-Wiedemann, Costello, Werner, hereditary retinoblastoma, nevoid basal cell carcinoma, & neurofibromatosis type I at ↑ risk of soft tissue sarcomas
IMAGING
General Features
Radiographic Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Al-Ibraheemi A et al: Selected diagnostically challenging pediatric soft tissue tumors. Surg Pathol Clin. 8(3):399-418, 2015
- Alaggio R et al: The evolution of pediatric soft tissue sarcoma classification in the last 50 years. Pediatr Dev Pathol. 18(6):481-94, 2015
- Sangkhathat S: Current management of pediatric soft tissue sarcomas. World J Clin Pediatr. 4(4):94-105, 2015
- Sargar K et al: MRI and CT of low-grade fibromyxoid sarcoma in children: a report from children's oncology group study ARST0332. AJR Am J Roentgenol. 205(2):414-20, 2015
- Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2014
- Partovi S et al: Magnetic resonance/positron emission tomography (MR/PET) oncologic applications: bone and soft tissue sarcoma. Semin Roentgenol. 49(4):345-52, 2014
- Thacker MM: Malignant soft tissue tumors in children. Orthop Clin North Am. 44(4):657-67, 2013
- Ferrari A et al: Neonatal soft tissue sarcomas. Semin Fetal Neonatal Med. 17(4):231-8, 2012
- Neubauer H et al: Diffusion-weighted MRI for detection and differentiation of musculoskeletal tumorous and tumor-like lesions in pediatric patients. World J Pediatr. 8(4):342-9, 2012
- Ferrari A et al: Soft tissue sarcoma across the age spectrum: a population-based study from the Surveillance Epidemiology and End Results database. Pediatr Blood Cancer. 57(6):943-9, 2011
- Stein-Wexler R: Pediatric soft tissue sarcomas. Semin Ultrasound CT MR. 32(5):470-88, 2011
- Bixby SD et al: Synovial sarcoma in children: imaging features and common benign mimics. AJR Am J Roentgenol. 195(4):1026-32, 2010
- Garcés-Iñigo EF et al: Extrarenal rhabdoid tumours outside the central nervous system in infancy. Pediatr Radiol. 39(8):817-22, 2009
- Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
- Navarro OM et al: Pediatric soft-tissue tumors and pseudo-tumors: MR imaging features with pathologic correlation: part 1. Imaging approach, pseudotumors, vascular lesions, and adipocytic tumors. Radiographics. 29(3):887-906, 2009
- Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
- Heterogeneous group of malignant mesenchymal tumors
- 4th most common group of malignancies in children < 16 years old
- Most common pediatric soft tissue sarcoma: Rhabdomyosarcoma (~ 19-50%)
- Extraskeletal Ewing sarcoma/primitive neuroectodermal tumor & synovial sarcoma next most common
- Many other less common lesions
- Heterogeneous group of malignant mesenchymal tumors
Associated Syndromes
- Li-Fraumeni, Noonan, Beckwith-Wiedemann, Costello, Werner, hereditary retinoblastoma, nevoid basal cell carcinoma, & neurofibromatosis type I at ↑ risk of soft tissue sarcomas
IMAGING
General Features
Radiographic Findings
MR Findings
Ultrasonographic Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Al-Ibraheemi A et al: Selected diagnostically challenging pediatric soft tissue tumors. Surg Pathol Clin. 8(3):399-418, 2015
- Alaggio R et al: The evolution of pediatric soft tissue sarcoma classification in the last 50 years. Pediatr Dev Pathol. 18(6):481-94, 2015
- Sangkhathat S: Current management of pediatric soft tissue sarcomas. World J Clin Pediatr. 4(4):94-105, 2015
- Sargar K et al: MRI and CT of low-grade fibromyxoid sarcoma in children: a report from children's oncology group study ARST0332. AJR Am J Roentgenol. 205(2):414-20, 2015
- Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2014
- Partovi S et al: Magnetic resonance/positron emission tomography (MR/PET) oncologic applications: bone and soft tissue sarcoma. Semin Roentgenol. 49(4):345-52, 2014
- Thacker MM: Malignant soft tissue tumors in children. Orthop Clin North Am. 44(4):657-67, 2013
- Ferrari A et al: Neonatal soft tissue sarcomas. Semin Fetal Neonatal Med. 17(4):231-8, 2012
- Neubauer H et al: Diffusion-weighted MRI for detection and differentiation of musculoskeletal tumorous and tumor-like lesions in pediatric patients. World J Pediatr. 8(4):342-9, 2012
- Ferrari A et al: Soft tissue sarcoma across the age spectrum: a population-based study from the Surveillance Epidemiology and End Results database. Pediatr Blood Cancer. 57(6):943-9, 2011
- Stein-Wexler R: Pediatric soft tissue sarcomas. Semin Ultrasound CT MR. 32(5):470-88, 2011
- Bixby SD et al: Synovial sarcoma in children: imaging features and common benign mimics. AJR Am J Roentgenol. 195(4):1026-32, 2010
- Garcés-Iñigo EF et al: Extrarenal rhabdoid tumours outside the central nervous system in infancy. Pediatr Radiol. 39(8):817-22, 2009
- Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
- Navarro OM et al: Pediatric soft-tissue tumors and pseudo-tumors: MR imaging features with pathologic correlation: part 1. Imaging approach, pseudotumors, vascular lesions, and adipocytic tumors. Radiographics. 29(3):887-906, 2009
- Murphey MD et al: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 29(7):2143-73, 2009
