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Ovarian Choriocarcinoma
Akram M. Shaaban, MBBCh; Evis Sala, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Malignant tumor of ovary with trophoblastic differentiation
              • 2 forms of ovarian choriocarcinoma exist
                • Nongestational choriocarcinoma
                  • Classified as ovarian germ cell tumor
                  • Tumor may be admixed with other malignant germ cell components
                • Gestational choriocarcinoma
                  • Represent metastasis from primary gestational choriocarcinoma in uterus
                  • Rarely, may arise from ovarian ectopic pregnancy

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Shaaban AM et al: Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics. 34(3):777-801, 2014
                                          2. Lalwani N et al: Rare, miscellaneous primary ovarian neoplasms: spectrum of cross-sectional imaging. Curr Probl Diagn Radiol. 41(2):73-80, 2012
                                          3. Peterson CM et al: Teratomas: a multimodality review. Curr Probl Diagn Radiol. 41(6):210-9, 2012
                                          4. Shanbhogue AK et al: Clinical syndromes associated with ovarian neoplasms: a comprehensive review. Radiographics. 30(4):903-19, 2010
                                          5. Allen SD et al: Radiology of gestational trophoblastic neoplasia. Clin Radiol. 61(4):301-13, 2006
                                          6. Koshy M et al: Malignant ovarian mixed germ cell tumour: a rare combination. Biomed Imaging Interv J. 1(2):e10, 2005
                                          7. Bazot M et al: Imaging of pure primary ovarian choriocarcinoma. AJR Am J Roentgenol. 182(6):1603-4, 2004
                                          8. Ozaki Y et al: Choriocarcinoma of the ovary associated with mucinous cystadenoma. Radiat Med. 19(1):55-9, 2001
                                          9. Simsek T et al: Primary pure choriocarcinoma of the ovary in reproductive ages: a case report. Eur J Gynaecol Oncol. 19(3):284-6, 1998
                                          10. Sashi R et al: Infantile choriocarcinoma: a case report with MRI, angiography and bone scintigraphy. Pediatr Radiol. 26(12):869-70, 1996
                                          11. Brammer HM 3rd et al: From the archives of the AFIP. Malignant germ cell tumors of the ovary: radiologic-pathologic correlation. Radiographics. 10(4):715-24, 1990
                                          12. Grover V et al: Primary pure choriocarcinoma of the ovary. Gynecol Obstet Invest. 30(1):61-3, 1990
                                          13. Axe SR et al: Choriocarcinoma of the ovary. Obstet Gynecol. 66(1):111-4, 1985
                                          14. Jacobs AJ et al: Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 37(10):603-9, 1982
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Malignant tumor of ovary with trophoblastic differentiation
                                                      • 2 forms of ovarian choriocarcinoma exist
                                                        • Nongestational choriocarcinoma
                                                          • Classified as ovarian germ cell tumor
                                                          • Tumor may be admixed with other malignant germ cell components
                                                        • Gestational choriocarcinoma
                                                          • Represent metastasis from primary gestational choriocarcinoma in uterus
                                                          • Rarely, may arise from ovarian ectopic pregnancy

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Shaaban AM et al: Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics. 34(3):777-801, 2014
                                                                                  2. Lalwani N et al: Rare, miscellaneous primary ovarian neoplasms: spectrum of cross-sectional imaging. Curr Probl Diagn Radiol. 41(2):73-80, 2012
                                                                                  3. Peterson CM et al: Teratomas: a multimodality review. Curr Probl Diagn Radiol. 41(6):210-9, 2012
                                                                                  4. Shanbhogue AK et al: Clinical syndromes associated with ovarian neoplasms: a comprehensive review. Radiographics. 30(4):903-19, 2010
                                                                                  5. Allen SD et al: Radiology of gestational trophoblastic neoplasia. Clin Radiol. 61(4):301-13, 2006
                                                                                  6. Koshy M et al: Malignant ovarian mixed germ cell tumour: a rare combination. Biomed Imaging Interv J. 1(2):e10, 2005
                                                                                  7. Bazot M et al: Imaging of pure primary ovarian choriocarcinoma. AJR Am J Roentgenol. 182(6):1603-4, 2004
                                                                                  8. Ozaki Y et al: Choriocarcinoma of the ovary associated with mucinous cystadenoma. Radiat Med. 19(1):55-9, 2001
                                                                                  9. Simsek T et al: Primary pure choriocarcinoma of the ovary in reproductive ages: a case report. Eur J Gynaecol Oncol. 19(3):284-6, 1998
                                                                                  10. Sashi R et al: Infantile choriocarcinoma: a case report with MRI, angiography and bone scintigraphy. Pediatr Radiol. 26(12):869-70, 1996
                                                                                  11. Brammer HM 3rd et al: From the archives of the AFIP. Malignant germ cell tumors of the ovary: radiologic-pathologic correlation. Radiographics. 10(4):715-24, 1990
                                                                                  12. Grover V et al: Primary pure choriocarcinoma of the ovary. Gynecol Obstet Invest. 30(1):61-3, 1990
                                                                                  13. Axe SR et al: Choriocarcinoma of the ovary. Obstet Gynecol. 66(1):111-4, 1985
                                                                                  14. Jacobs AJ et al: Pure choriocarcinoma of the ovary. Obstet Gynecol Surv. 37(10):603-9, 1982