Subtype of metastatic tumors that contain > 10% mucin-filled signet cells in cellular stroma
Usually from gastrointestinal tract with 76% arising from stomach
Krukenberg tumor is sometimes used inappropriately by some to include all metastatic ovarian carcinomas
High-stage mucinous tumors involving ovary frequently represent metastases from extraovarian primary sites and are often misdiagnosed as primary ovarian mucinous tumors
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Taylor EC et al: Multimodality imaging approach to ovarian neoplasms with pathologic correlation. Radiographics. 41(1):289-315, 2021
Kato MK et al: Novel classification of ovarian metastases originating from colorectal cancer by radiological imaging and macroscopic appearance. Int J Clin Oncol. 25(9):1663-71, 2020
Zulfiqar M et al: Krukenberg tumors: update on imaging and clinical features. AJR Am J Roentgenol. 215(4):1020-9, 2020
Jeung YJ et al: Krukenberg tumors of gastric origin versus colorectal origin. Obstet Gynecol Sci. 58(1):32-9, 2015
Nakamura Y et al: A Krukenberg tumor from an occult intramucosal gastric carcinoma identified during an autopsy. Case Rep Oncol Med. 2014:797429, 2014
Alvarado-Cabrero I et al: Metastatic ovarian tumors: a clinicopathologic study of 150 cases. Anal Quant Cytol Histol. 35(5):241-8, 2013
Guerriero S et al: Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor. Ultrasound Obstet Gynecol. 39(5):581-6, 2012
Willmott F et al: Radiological manifestations of metastasis to the ovary. J Clin Pathol. 65(7):585-90, 2012
Kitajima K et al: FDG PET/CT features of ovarian metastasis. Clin Radiol. 66(3):264-8, 2011
Maeda-Taniguchi M et al: Metastatic mucinous adenocarcinoma of the ovary is characterized by advanced patient age, small tumor size, and elevated serum CA125. Gynecol Obstet Invest. 72(3):196-202, 2011
Abe Y et al: A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging. Jpn J Radiol. 27(10):458-61, 2009
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References
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
TERMINOLOGY
Definitions
Secondary (metastatic) neoplasms to ovary
Krukenberg tumor
Subtype of metastatic tumors that contain > 10% mucin-filled signet cells in cellular stroma
Usually from gastrointestinal tract with 76% arising from stomach
Krukenberg tumor is sometimes used inappropriately by some to include all metastatic ovarian carcinomas
High-stage mucinous tumors involving ovary frequently represent metastases from extraovarian primary sites and are often misdiagnosed as primary ovarian mucinous tumors
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Taylor EC et al: Multimodality imaging approach to ovarian neoplasms with pathologic correlation. Radiographics. 41(1):289-315, 2021
Kato MK et al: Novel classification of ovarian metastases originating from colorectal cancer by radiological imaging and macroscopic appearance. Int J Clin Oncol. 25(9):1663-71, 2020
Zulfiqar M et al: Krukenberg tumors: update on imaging and clinical features. AJR Am J Roentgenol. 215(4):1020-9, 2020
Jeung YJ et al: Krukenberg tumors of gastric origin versus colorectal origin. Obstet Gynecol Sci. 58(1):32-9, 2015
Nakamura Y et al: A Krukenberg tumor from an occult intramucosal gastric carcinoma identified during an autopsy. Case Rep Oncol Med. 2014:797429, 2014
Alvarado-Cabrero I et al: Metastatic ovarian tumors: a clinicopathologic study of 150 cases. Anal Quant Cytol Histol. 35(5):241-8, 2013
Guerriero S et al: Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor. Ultrasound Obstet Gynecol. 39(5):581-6, 2012
Willmott F et al: Radiological manifestations of metastasis to the ovary. J Clin Pathol. 65(7):585-90, 2012
Kitajima K et al: FDG PET/CT features of ovarian metastasis. Clin Radiol. 66(3):264-8, 2011
Maeda-Taniguchi M et al: Metastatic mucinous adenocarcinoma of the ovary is characterized by advanced patient age, small tumor size, and elevated serum CA125. Gynecol Obstet Invest. 72(3):196-202, 2011
Abe Y et al: A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging. Jpn J Radiol. 27(10):458-61, 2009
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