Bookmarks
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
TERMINOLOGY
Definitions
- Secondary (metastatic) neoplasms to ovary
- Krukenberg tumor
- Term Krukenberg tumor is sometimes used loosely to include all metastatic ovarian carcinomas
- Classically describes subtype of metastatic tumors that contain > 10% mucin-filled signet cells in cellular stroma
- Usually from gastrointestinal tract (76% arising from stomach)
- High-stage mucinous tumors involving ovary frequently represent metastases from extraovarian primary sites
- Often misdiagnosed as primary ovarian mucinous tumors
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
PET/CT
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Fujii S et al: CT and MR imaging findings of bilateral ovarian metastasis from renal cell carcinoma: a case report. Acta Radiol Open. 10(2):2058460121990293, 2021
- Zulfiqar M et al: Krukenberg tumors: update on imaging and clinical features. AJR Am J Roentgenol. 215(4):1020-9, 2020
- Alvarado-Cabrero I et al: Metastatic ovarian tumors: a clinicopathologic study of 150 cases. Anal Quant Cytol Histol. 35(5):241-8, 2013
- Guerriero S et al: Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor. Ultrasound Obstet Gynecol. 39(5):581-6, 2012
- Ho L et al: Bilateral ovarian metastases from gastric carcinoma on FDG PET/CT. Clin Nucl Med. 37(5):524-7, 2012
- Willmott F et al: Radiological manifestations of metastasis to the ovary. J Clin Pathol. 65(7):585-90, 2012
- Soslow RA: Mucinous ovarian carcinoma: slippery business. Cancer. 117(3):451-3, 2011
- Zaino RJ et al: Advanced stage mucinous adenocarcinoma of the ovary is both rare and highly lethal: a Gynecologic Oncology Group study. Cancer. 117(3):554-62, 2011
- Abe Y et al: A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging. Jpn J Radiol. 27(10):458-61, 2009
- de Waal YR et al: Secondary ovarian malignancies: frequency, origin, and characteristics. Int J Gynecol Cancer. 19(7):1160-5, 2009
- Koyama T et al: Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation. Abdom Imaging. 32(6):784-95, 2007
- Testa AC et al: Imaging in gynecological disease (1): ultrasound features of metastases in the ovaries differ depending on the origin of the primary tumor. Ultrasound Obstet Gynecol. 29(5):505-11, 2007
- Chang WC et al: CT and MRI of adnexal masses in patients with primary nonovarian malignancy. AJR Am J Roentgenol. 186(4):1039-45, 2006
- Khunamornpong S et al: Primary and metastatic mucinous adenocarcinomas of the ovary: Evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol. 101(1):152-7, 2006
- Kiyokawa T et al: Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol. 30(3):277-99, 2006
- Alcazar JL et al: Transvaginal gray scale and color Doppler sonography in primary ovarian cancer and metastatic tumors to the ovary. J Ultrasound Med. 22(3):243-7, 2003
- Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
- Brown DL et al: Primary versus secondary ovarian malignancy: imaging findings of adnexal masses in the Radiology Diagnostic Oncology Group Study. Radiology. 219(1):213-8, 2001
- Hann LE et al: Adnexal masses in women with breast cancer: US findings with clinical and histopathologic correlation. Radiology. 216(1):242-7, 2000
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
TERMINOLOGY
Definitions
- Secondary (metastatic) neoplasms to ovary
- Krukenberg tumor
- Term Krukenberg tumor is sometimes used loosely to include all metastatic ovarian carcinomas
- Classically describes subtype of metastatic tumors that contain > 10% mucin-filled signet cells in cellular stroma
- Usually from gastrointestinal tract (76% arising from stomach)
- High-stage mucinous tumors involving ovary frequently represent metastases from extraovarian primary sites
- Often misdiagnosed as primary ovarian mucinous tumors
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
PET/CT
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Fujii S et al: CT and MR imaging findings of bilateral ovarian metastasis from renal cell carcinoma: a case report. Acta Radiol Open. 10(2):2058460121990293, 2021
- Zulfiqar M et al: Krukenberg tumors: update on imaging and clinical features. AJR Am J Roentgenol. 215(4):1020-9, 2020
- Alvarado-Cabrero I et al: Metastatic ovarian tumors: a clinicopathologic study of 150 cases. Anal Quant Cytol Histol. 35(5):241-8, 2013
- Guerriero S et al: Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor. Ultrasound Obstet Gynecol. 39(5):581-6, 2012
- Ho L et al: Bilateral ovarian metastases from gastric carcinoma on FDG PET/CT. Clin Nucl Med. 37(5):524-7, 2012
- Willmott F et al: Radiological manifestations of metastasis to the ovary. J Clin Pathol. 65(7):585-90, 2012
- Soslow RA: Mucinous ovarian carcinoma: slippery business. Cancer. 117(3):451-3, 2011
- Zaino RJ et al: Advanced stage mucinous adenocarcinoma of the ovary is both rare and highly lethal: a Gynecologic Oncology Group study. Cancer. 117(3):554-62, 2011
- Abe Y et al: A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging. Jpn J Radiol. 27(10):458-61, 2009
- de Waal YR et al: Secondary ovarian malignancies: frequency, origin, and characteristics. Int J Gynecol Cancer. 19(7):1160-5, 2009
- Koyama T et al: Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation. Abdom Imaging. 32(6):784-95, 2007
- Testa AC et al: Imaging in gynecological disease (1): ultrasound features of metastases in the ovaries differ depending on the origin of the primary tumor. Ultrasound Obstet Gynecol. 29(5):505-11, 2007
- Chang WC et al: CT and MRI of adnexal masses in patients with primary nonovarian malignancy. AJR Am J Roentgenol. 186(4):1039-45, 2006
- Khunamornpong S et al: Primary and metastatic mucinous adenocarcinomas of the ovary: Evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol. 101(1):152-7, 2006
- Kiyokawa T et al: Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol. 30(3):277-99, 2006
- Alcazar JL et al: Transvaginal gray scale and color Doppler sonography in primary ovarian cancer and metastatic tumors to the ovary. J Ultrasound Med. 22(3):243-7, 2003
- Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
- Brown DL et al: Primary versus secondary ovarian malignancy: imaging findings of adnexal masses in the Radiology Diagnostic Oncology Group Study. Radiology. 219(1):213-8, 2001
- Hann LE et al: Adnexal masses in women with breast cancer: US findings with clinical and histopathologic correlation. Radiology. 216(1):242-7, 2000
