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Ovarian Mixed Germ Cell Tumor, Embryonal Carcinoma and Polyembryoma
Akram M. Shaaban, MBBCh
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Classified as ovarian malignant germ cell tumor (OMGCT)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Shaaban AM et al: Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics. 34(3):777-801, 2014
                                          2. Peterson CM et al: Teratomas: a multimodality review. Curr Probl Diagn Radiol. 41(6):210-9, 2012
                                          3. Moniaga NC et al: Malignant mixed ovarian germ cell tumor with embryonal component. J Pediatr Adolesc Gynecol. 24(1):e1-3, 2011
                                          4. Cicin I et al: Malignant ovarian germ cell tumors: a single-institution experience. Am J Clin Oncol. 32(2):191-6, 2009
                                          5. De Backer A et al: Ovarian germ cell tumors in children: a clinical study of 66 patients. Pediatr Blood Cancer. 46(4):459-64, 2006
                                          6. Baker PM et al: Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol. 24(1):39-55, 2005
                                          7. Ulbright TM: Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol. 18 Suppl 2:S61-79, 2005
                                          8. Ulbright TM: Gonadal teratomas: a review and speculation. Adv Anat Pathol. 11(1):10-23, 2004
                                          9. Nishida T et al: Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. Eur J Obstet Gynecol Reprod Biol. 78(1):95-7, 1998
                                          10. Borghi A et al: [An ovarian mass in childhood: a case report] Pediatr Med Chir. 15(4):413-5, 1993
                                          11. Brammer HM 3rd et al: From the archives of the AFIP. Malignant germ cell tumors of the ovary: radiologic-pathologic correlation. Radiographics. 10(4):715-24, 1990
                                          12. Kawai M et al: Alpha-fetoprotein in malignant germ cell tumors of the ovary. Gynecol Oncol. 39(2):160-6, 1990
                                          13. Ueda G et al: Embryonal carcinoma of the ovary: a six-year survival. Int J Gynaecol Obstet. 31(3):287-92, 1990
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Classified as ovarian malignant germ cell tumor (OMGCT)

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Shaaban AM et al: Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics. 34(3):777-801, 2014
                                                                                  2. Peterson CM et al: Teratomas: a multimodality review. Curr Probl Diagn Radiol. 41(6):210-9, 2012
                                                                                  3. Moniaga NC et al: Malignant mixed ovarian germ cell tumor with embryonal component. J Pediatr Adolesc Gynecol. 24(1):e1-3, 2011
                                                                                  4. Cicin I et al: Malignant ovarian germ cell tumors: a single-institution experience. Am J Clin Oncol. 32(2):191-6, 2009
                                                                                  5. De Backer A et al: Ovarian germ cell tumors in children: a clinical study of 66 patients. Pediatr Blood Cancer. 46(4):459-64, 2006
                                                                                  6. Baker PM et al: Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol. 24(1):39-55, 2005
                                                                                  7. Ulbright TM: Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol. 18 Suppl 2:S61-79, 2005
                                                                                  8. Ulbright TM: Gonadal teratomas: a review and speculation. Adv Anat Pathol. 11(1):10-23, 2004
                                                                                  9. Nishida T et al: Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. Eur J Obstet Gynecol Reprod Biol. 78(1):95-7, 1998
                                                                                  10. Borghi A et al: [An ovarian mass in childhood: a case report] Pediatr Med Chir. 15(4):413-5, 1993
                                                                                  11. Brammer HM 3rd et al: From the archives of the AFIP. Malignant germ cell tumors of the ovary: radiologic-pathologic correlation. Radiographics. 10(4):715-24, 1990
                                                                                  12. Kawai M et al: Alpha-fetoprotein in malignant germ cell tumors of the ovary. Gynecol Oncol. 39(2):160-6, 1990
                                                                                  13. Ueda G et al: Embryonal carcinoma of the ovary: a six-year survival. Int J Gynaecol Obstet. 31(3):287-92, 1990