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Ovarian Teratoma
Sara M. O'Hara, MD, FAAP
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Dermoid tumor, dermoid cyst, cystic teratoma
          • Definitions

            • Teratomas are made up of various parenchymal cell types from > 1 germ layer, usually all 3
            • Teratomas generally lie in midline or paraxial & arise from totipotential cells
            • Term dermoid comes from skin-like lining found in many of these tumors

          IMAGING

          • General Features

            • Radiographic Findings

              • Ultrasonographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Hayes-Jordan A et al: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors: a novel treatment approach. Pediatr Surg Int. 32(1):71-3, 2016
                                      2. Hsu MH et al: Paraneoplastic neurological disorders in children with benign ovarian tumors. Brain Dev. 36(3):248-53, 2014
                                      3. Salvucci A et al: Pediatric anti-NMDA (N-methyl D-aspartate) receptor encephalitis. Pediatr Neurol. 50(5):507-10, 2014
                                      4. Loh AH et al: Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought? Pediatr Surg Int. 29(7):709-13, 2013
                                      5. Chabaud-Williamson M et al: Ovarian-sparing surgery for ovarian teratoma in children. Pediatr Blood Cancer. 57(3):429-34, 2011
                                      6. Epelman M et al: Imaging of pediatric ovarian neoplasms. Pediatr Radiol. 41(9):1085-99, 2011
                                      7. Alotaibi MO et al: Imaging of ovarian teratomas in children: a 9-year review. Can Assoc Radiol J. 61(1):23-8, 2010
                                      8. Poloni C et al: Severe childhood encephalopathy with dyskinesia and prolonged cognitive disturbances: evidence for anti-N-methyl-D-aspartate receptor encephalitis. Dev Med Child Neurol. 52(5):e78-82, 2010
                                      9. De Nayer AR et al: A subacute behavioral disorder in a female adolescent. Autoimmune anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Biol Psychiatry. 66(6):e13-4, 2009
                                      10. Saba L et al: Mature and immature ovarian teratomas: CT, US and MR imaging characteristics. Eur J Radiol. 72(3):454-63, 2009
                                      11. Islam S et al: Management and outcomes of ovarian masses in children and adolescents. Am Surg. 74(11):1062-5, 2008
                                      12. Park SB et al: Imaging findings of complications and unusual manifestations of ovarian teratomas. Radiographics. 28(4):969-83, 2008
                                      13. Benoit MF et al: Recurrent mature cystic ovarian teratoma in adolescence: atypical case of the growing teratoma syndrome. Obstet Gynecol. 105(5 Pt 2):1264-6, 2005
                                      14. Lai CH et al: Outcome and prognostic factors in ovarian germ cell malignancies. Gynecol Oncol. 96(3):784-91, 2005
                                      15. Phupong V et al: Ovarian teratoma with diffused peritoneal reactions mimicking advanced ovarian malignancy. Arch Gynecol Obstet. 270(3):189-91, 2004
                                      16. Rha SE et al: Atypical CT and MRI manifestations of mature ovarian cystic teratomas. AJR Am J Roentgenol. 183(3):743-50, 2004
                                      17. Umesaki N et al: MR and ultrasound imaging of floating globules in mature ovarian cystic teratoma. Gynecol Obstet Invest. 58(3):130-2, 2004
                                      18. PDQ Pediatric Treatment Editorial Board: childhood extracranial germ Cell tumors treatment (PDQ®): Health Professional Version 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Dermoid tumor, dermoid cyst, cystic teratoma
                                              • Definitions

                                                • Teratomas are made up of various parenchymal cell types from > 1 germ layer, usually all 3
                                                • Teratomas generally lie in midline or paraxial & arise from totipotential cells
                                                • Term dermoid comes from skin-like lining found in many of these tumors

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • Ultrasonographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Hayes-Jordan A et al: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors: a novel treatment approach. Pediatr Surg Int. 32(1):71-3, 2016
                                                                          2. Hsu MH et al: Paraneoplastic neurological disorders in children with benign ovarian tumors. Brain Dev. 36(3):248-53, 2014
                                                                          3. Salvucci A et al: Pediatric anti-NMDA (N-methyl D-aspartate) receptor encephalitis. Pediatr Neurol. 50(5):507-10, 2014
                                                                          4. Loh AH et al: Diagnostic accuracy of preoperative alpha-fetoprotein as an ovarian tumor marker in children and adolescents: not as good as we thought? Pediatr Surg Int. 29(7):709-13, 2013
                                                                          5. Chabaud-Williamson M et al: Ovarian-sparing surgery for ovarian teratoma in children. Pediatr Blood Cancer. 57(3):429-34, 2011
                                                                          6. Epelman M et al: Imaging of pediatric ovarian neoplasms. Pediatr Radiol. 41(9):1085-99, 2011
                                                                          7. Alotaibi MO et al: Imaging of ovarian teratomas in children: a 9-year review. Can Assoc Radiol J. 61(1):23-8, 2010
                                                                          8. Poloni C et al: Severe childhood encephalopathy with dyskinesia and prolonged cognitive disturbances: evidence for anti-N-methyl-D-aspartate receptor encephalitis. Dev Med Child Neurol. 52(5):e78-82, 2010
                                                                          9. De Nayer AR et al: A subacute behavioral disorder in a female adolescent. Autoimmune anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Biol Psychiatry. 66(6):e13-4, 2009
                                                                          10. Saba L et al: Mature and immature ovarian teratomas: CT, US and MR imaging characteristics. Eur J Radiol. 72(3):454-63, 2009
                                                                          11. Islam S et al: Management and outcomes of ovarian masses in children and adolescents. Am Surg. 74(11):1062-5, 2008
                                                                          12. Park SB et al: Imaging findings of complications and unusual manifestations of ovarian teratomas. Radiographics. 28(4):969-83, 2008
                                                                          13. Benoit MF et al: Recurrent mature cystic ovarian teratoma in adolescence: atypical case of the growing teratoma syndrome. Obstet Gynecol. 105(5 Pt 2):1264-6, 2005
                                                                          14. Lai CH et al: Outcome and prognostic factors in ovarian germ cell malignancies. Gynecol Oncol. 96(3):784-91, 2005
                                                                          15. Phupong V et al: Ovarian teratoma with diffused peritoneal reactions mimicking advanced ovarian malignancy. Arch Gynecol Obstet. 270(3):189-91, 2004
                                                                          16. Rha SE et al: Atypical CT and MRI manifestations of mature ovarian cystic teratomas. AJR Am J Roentgenol. 183(3):743-50, 2004
                                                                          17. Umesaki N et al: MR and ultrasound imaging of floating globules in mature ovarian cystic teratoma. Gynecol Obstet Invest. 58(3):130-2, 2004
                                                                          18. PDQ Pediatric Treatment Editorial Board: childhood extracranial germ Cell tumors treatment (PDQ®): Health Professional Version 2002