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Overlap Syndrome/Mixed Connective Tissue Disease
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Abbreviations

          • Mixed connective tissue disease (MCTD)
        • Synonyms

          • Undifferentiated connective tissue disease (preferred term); overlap syndrome
        • Definitions

          • Combination or overlap of clinical symptoms
            • Plus high titers of serum antibodies that react with nuclear ribonuclear protein (U1-RNP)
            • Overlap syndrome: Systemic sclerosis (PSS) & inflammatory myositis
            • MCTD: Systemic lupus erythematosus (SLE) & PSS & polymyositis

        IMAGING

        • General Features

          PATHOLOGY

          • General Features

            CLINICAL ISSUES

            • Presentation

              • Natural History & Prognosis

                • Treatment

                  Selected References

                  1. Breda L et al: Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update. Semin Arthritis Rheum. 40(1):53-72, 2010
                  2. Antoniou KM et al: Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement. Eur Respir J. 33(4):882-96, 2009
                  3. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                  4. Swart JF et al: Diagnostic workup for mixed connective tissue disease in childhood. Isr Med Assoc J. 10(8-9):650-2, 2008
                  Related Anatomy
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                  References
                  Tables

                  Tables

                  KEY FACTS

                  • Terminology

                    • Imaging

                      • Clinical Issues

                        TERMINOLOGY

                        • Abbreviations

                          • Mixed connective tissue disease (MCTD)
                        • Synonyms

                          • Undifferentiated connective tissue disease (preferred term); overlap syndrome
                        • Definitions

                          • Combination or overlap of clinical symptoms
                            • Plus high titers of serum antibodies that react with nuclear ribonuclear protein (U1-RNP)
                            • Overlap syndrome: Systemic sclerosis (PSS) & inflammatory myositis
                            • MCTD: Systemic lupus erythematosus (SLE) & PSS & polymyositis

                        IMAGING

                        • General Features

                          PATHOLOGY

                          • General Features

                            CLINICAL ISSUES

                            • Presentation

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Breda L et al: Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update. Semin Arthritis Rheum. 40(1):53-72, 2010
                                  2. Antoniou KM et al: Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement. Eur Respir J. 33(4):882-96, 2009
                                  3. Schulze M et al: MRI findings in inflammatory muscle diseases and their noninflammatory mimics. AJR Am J Roentgenol. 192(6):1708-16, 2009
                                  4. Swart JF et al: Diagnostic workup for mixed connective tissue disease in childhood. Isr Med Assoc J. 10(8-9):650-2, 2008